ES464552A2 - Improvements introduced in the object of the main patent by: procedure for the preparation of 5-methyl-isoxazol-4-carboxylic acid anylides. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Improvements introduced in the object of the main patent number 448,386, requested on may 31, 1976, by "process for the preparation of 5-methyl-isoxazole-4-caraboxylic acid anilides for the preparation of 5-methyl acid amides -isoxazole-4-carboxylic acid of the formula i ** formula ** in which r stands for an unsaturated heterocyclic radical of one, two or three nuclei with 3 to 13 carbon atoms and one, two, three or four heteroatoms of the group of oxygen, sulfur and nitrogen, of which at most one is different from nitrogen, in the ring system which is optionally substituted one, two or three times with alkyl or alkoxy in each case with one, two or three carbon atoms, halogen, such as fluorine, chlorine, bromine or iodine, nitro, hydroxy, carboxy, carbamoyl or the oxo group, as well as the salts by addition of these compounds with a physiologically compatible acid, said improvements are characterized by the fact that makes re a 5-methylisoxazole-4-carboxylic acid derivative of the formula ii ** formula wherein x means a halogen atom, preferably chlorine or bromine, a group yo or zo-co-o, represented and optionally substituted phenyl, one two or three times with fluorine, chlorine, bromine, iodine, methyl, ethyl, methoxy, ethoxy, trifluoromethyl, nitro or cyano or the acyl radical corresponding to formula ii and z representing alkyl of 1 to 4 carbon atoms, benzyl or phenyl, with a heterocyclic, unsaturated amine of formula iii h2n-r (III) in which r has the meaning indicated with respect to formula i (Machine-translation by Google Translate, not legally binding)