ES465073A1 - Procedimiento de obtencion de naloxona a partir de tebaina - Google Patents
Procedimiento de obtencion de naloxona a partir de tebainaInfo
- Publication number
- ES465073A1 ES465073A1 ES465073A ES465073A ES465073A1 ES 465073 A1 ES465073 A1 ES 465073A1 ES 465073 A ES465073 A ES 465073A ES 465073 A ES465073 A ES 465073A ES 465073 A1 ES465073 A1 ES 465073A1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- naloxone
- translation
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 title abstract 3
- 229960004127 naloxone Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 abstract 2
- FQXXSQDCDRQNQE-UHFFFAOYSA-N markiertes Thebain Natural products COC1=CC=C2C(N(CC3)C)CC4=CC=C(OC)C5=C4C23C1O5 FQXXSQDCDRQNQE-UHFFFAOYSA-N 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229960005118 oxymorphone Drugs 0.000 abstract 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 2
- FQXXSQDCDRQNQE-VMDGZTHMSA-N thebaine Chemical compound C([C@@H](N(CC1)C)C2=CC=C3OC)C4=CC=C(OC)C5=C4[C@@]21[C@H]3O5 FQXXSQDCDRQNQE-VMDGZTHMSA-N 0.000 abstract 2
- 229930003945 thebaine Natural products 0.000 abstract 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- -1 alkyl chloroformates Chemical class 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 230000001335 demethylating effect Effects 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229960002085 oxycodone Drugs 0.000 abstract 1
- 150000003222 pyridines Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 125000004417 unsaturated alkyl group Chemical group 0.000 abstract 1
- 238000005406 washing Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedimiento de obtención de naloxona a partir de tebaina.- caracterizado esencialmente porque consiste en obtener separadamente dihidroxicodeinona partiendo de la tebaina, rompiendo posteriormente el éter fenólico de la dihidroxicodeinona mediante sales de piridina de un ácido fuerte y en el seno de un disolvente tal como dimetilsulfóxido, desmetilando la oxicodona, obteniendo como elemento intermedio la oximorfona, tratando posteriormente dicha oximorfona con cloroformiatos de alkilo, resguardando el grupo fenólico y eliminando el metilo unido al nitrógeno por transformación a un derivado intermedio del tipo uretano obteniendo la nor- dihidroximorfinona por hidrólisis del derivado intermedio, produciendo seguidamente la alkilación del nitrógeno mediante haluros de alkilo no saturados, obteniendo naloxona en estado básico y sólido, siendo sometida dicha naoloxona a un lavado y posterior - cristalización, que da lugar a un producto puro que es base de partida para la formación de sales denaloxona.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES465073A ES465073A1 (es) | 1977-12-14 | 1977-12-14 | Procedimiento de obtencion de naloxona a partir de tebaina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES465073A ES465073A1 (es) | 1977-12-14 | 1977-12-14 | Procedimiento de obtencion de naloxona a partir de tebaina |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES465073A1 true ES465073A1 (es) | 1979-01-01 |
Family
ID=8475086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES465073A Expired ES465073A1 (es) | 1977-12-14 | 1977-12-14 | Procedimiento de obtencion de naloxona a partir de tebaina |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES465073A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3252055A1 (en) | 2016-05-31 | 2017-12-06 | Alcaliber Investigacion Desarrollo e Innovacion, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
-
1977
- 1977-12-14 ES ES465073A patent/ES465073A1/es not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3252055A1 (en) | 2016-05-31 | 2017-12-06 | Alcaliber Investigacion Desarrollo e Innovacion, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
| WO2017207519A1 (en) | 2016-05-31 | 2017-12-07 | Alcaliber Investigación Desarrollo E Innovación, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
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