ES465524A1 - Procedimiento para la obtencion de nuevas feniletilaminas. - Google Patents

Procedimiento para la obtencion de nuevas feniletilaminas.

Info

Publication number
ES465524A1
ES465524A1 ES465524A ES465524A ES465524A1 ES 465524 A1 ES465524 A1 ES 465524A1 ES 465524 A ES465524 A ES 465524A ES 465524 A ES465524 A ES 465524A ES 465524 A1 ES465524 A1 ES 465524A1
Authority
ES
Spain
Prior art keywords
dihydroisoquinolinones
phenylalkylamino
alkyl
pharmaceutical compositions
methods employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465524A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of ES465524A1 publication Critical patent/ES465524A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento para la obtención de nuevas feniletinas de la fórmula general***(ver fórmula I)en la que R1R2R5 y R6que pueden ser iguales o diferentessignifican átomos de hidrógeno o grupos alcohilo inferior o R5 también un grupo bencilo.
ES465524A 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas. Expired ES465524A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2639718A DE2639718C2 (de) 1976-09-03 1976-09-03 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ES465524A1 true ES465524A1 (es) 1978-09-16

Family

ID=5987076

Family Applications (8)

Application Number Title Priority Date Filing Date
ES462006A Expired ES462006A1 (es) 1976-09-03 1977-08-31 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465525A Expired ES465525A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465526A Expired ES465526A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465524A Expired ES465524A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465523A Expired ES465523A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465528A Expired ES465528A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465527A Expired ES465527A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465529A Expired ES465529A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES462006A Expired ES462006A1 (es) 1976-09-03 1977-08-31 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465525A Expired ES465525A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465526A Expired ES465526A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES465523A Expired ES465523A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465528A Expired ES465528A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465527A Expired ES465527A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.
ES465529A Expired ES465529A1 (es) 1976-09-03 1977-12-28 Procedimiento para la obtencion de nuevas feniletilaminas.

Country Status (32)

Country Link
US (1) US4137318A (es)
JP (1) JPS6026107B2 (es)
AT (1) AT357536B (es)
AU (1) AU513325B2 (es)
BE (1) BE858383A (es)
BG (1) BG31377A3 (es)
CA (1) CA1086726A (es)
CS (1) CS197300B2 (es)
DD (1) DD132585A5 (es)
DE (1) DE2639718C2 (es)
DK (1) DK392877A (es)
ES (8) ES462006A1 (es)
FI (1) FI63225C (es)
FR (1) FR2363556A1 (es)
GB (1) GB1548844A (es)
GR (1) GR63605B (es)
HK (1) HK54082A (es)
IE (1) IE45674B1 (es)
IL (1) IL52867A (es)
LU (1) LU78066A1 (es)
MY (1) MY8300244A (es)
NL (1) NL7709678A (es)
NO (1) NO147986C (es)
NZ (1) NZ185081A (es)
PH (1) PH16512A (es)
PL (3) PL110397B1 (es)
PT (1) PT66987B (es)
RO (1) RO71931A (es)
SE (1) SE437515B (es)
SG (1) SG45082G (es)
SU (3) SU659081A3 (es)
ZA (1) ZA775311B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393210A (en) * 1980-08-28 1983-07-12 Seiyaku Co., Ltd. 1(2H)-Isoquinolone compounds and acid addition salts thereof
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3242345A1 (de) * 1982-11-16 1984-05-17 Dr. Karl Thomae Gmbh, 7950 Biberach Verfahren zur herstellung von benzazepinderivaten
DE3343801A1 (de) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPS6220402U (es) * 1985-07-22 1987-02-06
DE3541811A1 (de) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
GB8609331D0 (en) * 1986-04-16 1986-05-21 Pfizer Ltd Anti-arrythmia agents
DE3631013A1 (de) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3640641A1 (de) * 1986-11-28 1988-07-14 Thomae Gmbh Dr K Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) * 1987-10-30 1989-05-11 Thomae Gmbh Dr K Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
PL378754A1 (pl) * 2003-03-03 2006-05-15 F.Hoffmann-La Roche Ag 2,5- i 2,6-Podstawione tetrahydroizochinoliny do stosowania jako modulatory 5-HT6
CN101250157B (zh) * 2008-03-07 2012-03-28 西安交通大学 2-取代-3,4-二氢-1-异喹啉酮类合成方法及其制备心血管药物的用途
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils
SE368009B (es) * 1971-09-16 1974-06-17 Kabi Ab
US4021558A (en) * 1973-09-08 1977-05-03 Boehringer Ingelheim Gmbh 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents
AT330777B (de) * 1973-09-08 1976-07-26 Thomae Gmbh Dr K Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
CH605914A5 (es) * 1974-07-31 1978-10-13 Ciba Geigy Ag

Also Published As

Publication number Publication date
IL52867A0 (en) 1977-11-30
ES465527A1 (es) 1978-09-16
DE2639718C2 (de) 1987-03-05
GR63605B (en) 1979-11-26
IL52867A (en) 1980-07-31
AT357536B (de) 1980-07-10
JPS5331672A (en) 1978-03-25
HK54082A (en) 1982-12-31
AU513325B2 (en) 1980-11-27
ES465523A1 (es) 1978-09-16
SG45082G (en) 1983-02-25
CS197300B2 (en) 1980-04-30
PL112814B1 (en) 1980-11-29
RO71931A (ro) 1981-11-24
DK392877A (da) 1978-03-04
NO147986C (no) 1983-07-20
ES465528A1 (es) 1978-09-16
ES465529A1 (es) 1978-09-16
PL109757B1 (en) 1980-06-30
DE2639718A1 (de) 1978-03-16
FR2363556B1 (es) 1981-09-11
NO147986B (no) 1983-04-11
BG31377A3 (bg) 1981-12-15
CA1086726A (en) 1980-09-30
AU2851677A (en) 1979-03-08
FI63225C (fi) 1983-05-10
NZ185081A (en) 1979-11-01
LU78066A1 (es) 1978-10-17
BE858383A (fr) 1978-03-02
IE45674B1 (en) 1982-10-20
PH16512A (en) 1983-11-08
SE437515B (sv) 1985-03-04
SU700061A3 (ru) 1979-11-25
PL110397B1 (en) 1980-07-31
ES462006A1 (es) 1978-06-16
FI63225B (fi) 1983-01-31
ATA600477A (de) 1979-12-15
GB1548844A (en) 1979-07-18
NO773038L (no) 1978-03-06
NL7709678A (nl) 1978-03-07
DD132585A5 (de) 1978-10-11
FI772262A7 (fi) 1978-03-04
ES465526A1 (es) 1978-09-16
SU688127A3 (ru) 1979-09-25
IE45674L (en) 1978-03-03
FR2363556A1 (fr) 1978-03-31
JPS6026107B2 (ja) 1985-06-21
PL200630A1 (pl) 1979-02-12
ES465525A1 (es) 1978-09-16
SU659081A3 (ru) 1979-04-25
ZA775311B (en) 1979-05-30
US4137318A (en) 1979-01-30
MY8300244A (en) 1983-12-31
SE7709865L (sv) 1978-03-04
PT66987A (de) 1977-10-01
PT66987B (de) 1979-09-12

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991221