ES466237A1 - 3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzyl propylamine and its salts - Google Patents

3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzyl propylamine and its salts

Info

Publication number
ES466237A1
ES466237A1 ES466237A ES466237A ES466237A1 ES 466237 A1 ES466237 A1 ES 466237A1 ES 466237 A ES466237 A ES 466237A ES 466237 A ES466237 A ES 466237A ES 466237 A1 ES466237 A1 ES 466237A1
Authority
ES
Spain
Prior art keywords
pyrrolidino
isobutoxy
phenyl
salts
propylamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES466237A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre Europeen de Recherches Mauvernay CERM
Original Assignee
Centre Europeen de Recherches Mauvernay CERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Europeen de Recherches Mauvernay CERM filed Critical Centre Europeen de Recherches Mauvernay CERM
Publication of ES466237A1 publication Critical patent/ES466237A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The compound of formula (I) has a molecular mass M of 366 and a boiling point B.p.0.5 of 192 DEG C. It can be used for the treatment of cardiovascular ailments, especially for the treatment of angor (angina).
ES466237A 1977-01-25 1978-01-21 3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzyl propylamine and its salts Expired ES466237A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7702058A FR2378024A1 (en) 1977-01-25 1977-01-25 NEW SUBSTITUTED PROPYLAMINE, OBTAINING AND APPLYING

Publications (1)

Publication Number Publication Date
ES466237A1 true ES466237A1 (en) 1978-10-16

Family

ID=9185890

Family Applications (1)

Application Number Title Priority Date Filing Date
ES466237A Expired ES466237A1 (en) 1977-01-25 1978-01-21 3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzyl propylamine and its salts

Country Status (12)

Country Link
JP (1) JPS5392764A (en)
AU (1) AU516479B2 (en)
BE (1) BE863214A (en)
CH (1) CH628889A5 (en)
DE (1) DE2802864C2 (en)
ES (1) ES466237A1 (en)
FR (1) FR2378024A1 (en)
GB (1) GB1595031A (en)
IL (1) IL53816A0 (en)
NL (1) NL189258C (en)
PT (1) PT67556B (en)
ZA (1) ZA78426B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU559555B2 (en) * 1981-12-28 1987-03-12 Carter-Wallace, Inc. Chemical process
DK156396C (en) * 1983-09-27 1990-01-08 Cerm Cent Europ Rech Mauvernay 2- (N-PYRROLIDINO) -3-ISOBUTOXY-N-SUBSTITUTED PHENYL-N-BENZYL-PROPYLAMINE COMPOUNDS AND PHARMACEUTICAL AGENTS CONTAINING THESE
AU568704B2 (en) * 1983-11-11 1988-01-07 Akzo N.V. Ether of n-propanolamine derivative
GB8330197D0 (en) * 1983-11-11 1983-12-21 Akzo Nv Ether of n-propanolamine derivative
FR2558161B1 (en) * 1984-01-18 1987-01-23 Cerm Cent Europ Rech Mauvernay 3-ALKOXY 2- (N-PYRROLIDINO) N-FURYLMETHYL OR N-THIENYLMETHYL N-PYRIDYL PROPYLAMINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2558160B1 (en) * 1984-01-18 1986-05-30 Cerm Cent Europ Rech Mauvernay 3-ALKOXY 2- (N-PYRROLIDINO) -N-PYRIMIDINYL OR -PYRAZINYL PROPYLAMINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2558159B1 (en) * 1984-01-18 1986-06-13 Cerm Cent Europ Rech Mauvernay 3-ALKOXY 2- (N-PYRROLIDINO) -N-PYRIDYL-N-ARYLMETHYL-PROPYLAMINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
DE3726632A1 (en) * 1987-08-11 1989-05-18 Boehringer Mannheim Gmbh 1,2-DIAMINO COMPOUNDS, METHOD FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
DE3726633A1 (en) * 1987-08-11 1989-02-23 Boehringer Mannheim Gmbh NEW 1,2-DIAMINO COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
JP2678758B2 (en) * 1988-02-16 1997-11-17 興和株式会社 Novel propane derivative
WO2016098128A1 (en) * 2014-12-16 2016-06-23 Council Of Scientific & Industrial Research Process for the preparation of bepridil

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795735A (en) * 1972-03-06 1973-06-18 Cerm Cent Europ Rech Mauvernay NEW ETHYLENEDIAMINES SUBSTITUTES WITH CARDIOVASCULAR ACTIVITY

Also Published As

Publication number Publication date
FR2378024B1 (en) 1979-05-11
NL189258C (en) 1993-02-16
JPS5429493B2 (en) 1979-09-25
AU3266078A (en) 1979-08-02
IL53816A0 (en) 1978-04-30
PT67556A (en) 1978-02-01
NL7800753A (en) 1978-07-27
PT67556B (en) 1979-06-18
FR2378024A1 (en) 1978-08-18
ZA78426B (en) 1979-01-31
CH628889A5 (en) 1982-03-31
BE863214A (en) 1978-07-24
NL189258B (en) 1992-09-16
GB1595031A (en) 1981-08-05
JPS5392764A (en) 1978-08-15
AU516479B2 (en) 1981-06-04
DE2802864C2 (en) 1982-12-09
DE2802864A1 (en) 1978-07-27

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