ES466867A1 - 2,4 - dichlorophenyl - imidazolyl - ethan - ones and -ols a process for their preparation and their use as medicaments - Google Patents
2,4 - dichlorophenyl - imidazolyl - ethan - ones and -ols a process for their preparation and their use as medicamentsInfo
- Publication number
- ES466867A1 ES466867A1 ES466867A ES466867A ES466867A1 ES 466867 A1 ES466867 A1 ES 466867A1 ES 466867 A ES466867 A ES 466867A ES 466867 A ES466867 A ES 466867A ES 466867 A1 ES466867 A1 ES 466867A1
- Authority
- ES
- Spain
- Prior art keywords
- ethan
- ols
- dichlorophenyl
- imidazolyl
- medicaments
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- TYKOUAUXOORKDQ-UHFFFAOYSA-N 2-(2,4-dichlorophenyl)-1-(1h-imidazol-2-yl)ethanone Chemical class ClC1=CC(Cl)=CC=C1CC(=O)C1=NC=CN1 TYKOUAUXOORKDQ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001857 anti-mycotic effect Effects 0.000 abstract 1
- 239000002543 antimycotic Substances 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000468 ketone group Chemical group 0.000 abstract 1
- -1 phenoxyimidazolyl Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
2,4-Dichlorophenylimidazolyl ethanones or ethanols of the general formula < IMAGE > in which A represents a keto group or a CH(OH) group, X represents halogen, alkyl, or optionally substituted phenyl, and n represents zero or an integer from 1 to 3, and their physiologically tolerated salts, are therapeutically active and are obtained by reacting a compound of the formula II with imidazole. Surprisingly, the active compounds according to the invention demonstrate better antimycotic, therapeutically useful, activity than do the phenoxyimidazolyl derivatives known from the state of the art, which derivatives are the most closely related compounds from the point of view of their chemistry and the nature of their effect.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772705677 DE2705677A1 (en) | 1977-02-11 | 1977-02-11 | 2,4-DICHLOROPHENYL-IMIDAZOLYL-AETHANONE (OLE), METHOD FOR MANUFACTURING AND USING THEY AS A MEDICINAL PRODUCT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES466867A1 true ES466867A1 (en) | 1978-10-01 |
Family
ID=6000864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466867A Expired ES466867A1 (en) | 1977-02-11 | 1978-02-10 | 2,4 - dichlorophenyl - imidazolyl - ethan - ones and -ols a process for their preparation and their use as medicaments |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS53101375A (en) |
| AT (1) | AT361910B (en) |
| AU (1) | AU516580B2 (en) |
| BE (1) | BE863851A (en) |
| CA (1) | CA1097356A (en) |
| CH (1) | CH634058A5 (en) |
| DE (1) | DE2705677A1 (en) |
| DK (1) | DK61378A (en) |
| ES (1) | ES466867A1 (en) |
| FI (1) | FI66851C (en) |
| FR (1) | FR2380263A1 (en) |
| GB (1) | GB1554841A (en) |
| IL (1) | IL54001A (en) |
| IT (1) | IT1093702B (en) |
| NL (1) | NL177214C (en) |
| NO (1) | NO147448C (en) |
| SE (1) | SE442401B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2713777C3 (en) * | 1977-03-29 | 1979-10-31 | Bayer Ag, 5090 Leverkusen | Process for the preparation of l-azolyl-33-dimethyl-l-phenoxy-butan-2-ones |
| AT394800B (en) * | 1979-09-06 | 1992-06-25 | Bristol Myers Squibb Co | Composition for inhibiting the growth of fungi and bacteria |
| AT382147B (en) * | 1979-09-06 | 1987-01-12 | Bristol Myers Co | METHOD FOR PRODUCING NEW 1-PHENAETHYLIMIDAZOLE DERIVATIVES |
| GB2086885A (en) * | 1980-09-13 | 1982-05-19 | Beecham Group Ltd | Imidazoles |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2105490C3 (en) * | 1971-02-05 | 1979-06-13 | Bayer Ag, 5090 Leverkusen | 1-imidazolyl ketone derivatives |
-
1977
- 1977-02-11 DE DE19772705677 patent/DE2705677A1/en not_active Withdrawn
-
1978
- 1978-01-27 NO NO780315A patent/NO147448C/en unknown
- 1978-02-02 CH CH117278A patent/CH634058A5/en not_active IP Right Cessation
- 1978-02-07 GB GB4884/78A patent/GB1554841A/en not_active Expired
- 1978-02-09 SE SE7801526A patent/SE442401B/en unknown
- 1978-02-09 JP JP1305978A patent/JPS53101375A/en active Pending
- 1978-02-09 FI FI780431A patent/FI66851C/en not_active IP Right Cessation
- 1978-02-09 IL IL54001A patent/IL54001A/en unknown
- 1978-02-09 IT IT20129/78A patent/IT1093702B/en active
- 1978-02-09 CA CA296,581A patent/CA1097356A/en not_active Expired
- 1978-02-10 ES ES466867A patent/ES466867A1/en not_active Expired
- 1978-02-10 AT AT94378A patent/AT361910B/en not_active IP Right Cessation
- 1978-02-10 FR FR7803833A patent/FR2380263A1/en active Granted
- 1978-02-10 NL NLAANVRAGE7801579,A patent/NL177214C/en not_active IP Right Cessation
- 1978-02-10 BE BE185068A patent/BE863851A/en not_active IP Right Cessation
- 1978-02-10 DK DK61378A patent/DK61378A/en not_active Application Discontinuation
-
1979
- 1979-02-13 AU AU33243/78A patent/AU516580B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| SE442401B (en) | 1985-12-23 |
| FI780431A7 (en) | 1978-08-12 |
| CA1097356A (en) | 1981-03-10 |
| JPS53101375A (en) | 1978-09-04 |
| NO780315L (en) | 1978-08-14 |
| AU516580B2 (en) | 1981-06-11 |
| FR2380263B1 (en) | 1982-11-19 |
| IT1093702B (en) | 1985-07-26 |
| NO147448C (en) | 1983-04-13 |
| NL177214B (en) | 1985-03-18 |
| NL7801579A (en) | 1978-08-15 |
| DK61378A (en) | 1978-08-12 |
| AT361910B (en) | 1981-04-10 |
| ATA94378A (en) | 1980-09-15 |
| FR2380263A1 (en) | 1978-09-08 |
| FI66851B (en) | 1984-08-31 |
| IL54001A (en) | 1981-09-13 |
| IT7820129A0 (en) | 1978-02-09 |
| CH634058A5 (en) | 1983-01-14 |
| FI66851C (en) | 1984-12-10 |
| IL54001A0 (en) | 1978-04-30 |
| NO147448B (en) | 1983-01-03 |
| BE863851A (en) | 1978-08-10 |
| SE7801526L (en) | 1978-08-12 |
| NL177214C (en) | 1985-08-16 |
| GB1554841A (en) | 1979-10-31 |
| AU3324378A (en) | 1979-08-23 |
| DE2705677A1 (en) | 1978-08-17 |
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