ES466892A1 - Un procedimiento de preparacion de una composicion secues- tradora de acidos biliares. - Google Patents

Un procedimiento de preparacion de una composicion secues- tradora de acidos biliares.

Info

Publication number
ES466892A1
ES466892A1 ES466892A ES466892A ES466892A1 ES 466892 A1 ES466892 A1 ES 466892A1 ES 466892 A ES466892 A ES 466892A ES 466892 A ES466892 A ES 466892A ES 466892 A1 ES466892 A1 ES 466892A1
Authority
ES
Spain
Prior art keywords
preparation
procedure
composition
trimethylammoniopropyl
iminium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES466892A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES466892A1 publication Critical patent/ES466892A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

La invención aquí descrita se refiere a una nueva composición farmacológicamente aceptable, no adhesiva y fluida, que comprende polímeros cuaternarios de ioneno eficaces como secuestradores de los ácidos biliares, tales como poli{dicioruro de{metil-(3- trimetilamoniopropil)iminio}trimetileno}, adsorbido sobre un agregado sólido pulverulento de gran relación de superficie a masa, tal como sílice ahumada. También se refiere al nuevo procedimiento para la preparación de estas composiciones de adsorbato que consiste en formar una suspensión sustancialmente uniforme del agregado sólido finamente dividido en una solución acuosa de poli-{dicloruro de{metil- (3-trimetilamoniopropil)iminio}trimetileno}, separar por evaporación el agua de la suspensión y secar el adsorbato así producido.
ES466892A 1977-02-17 1978-02-10 Un procedimiento de preparacion de una composicion secues- tradora de acidos biliares. Expired ES466892A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US76949177A 1977-02-17 1977-02-17

Publications (1)

Publication Number Publication Date
ES466892A1 true ES466892A1 (es) 1979-08-16

Family

ID=25085598

Family Applications (1)

Application Number Title Priority Date Filing Date
ES466892A Expired ES466892A1 (es) 1977-02-17 1978-02-10 Un procedimiento de preparacion de una composicion secues- tradora de acidos biliares.

Country Status (26)

Country Link
JP (1) JPS53102958A (es)
AT (1) AT363173B (es)
AU (1) AU518127B2 (es)
BE (1) BE863930A (es)
CA (1) CA1109395A (es)
CH (1) CH636012A5 (es)
DE (1) DE2806707A1 (es)
DK (1) DK46578A (es)
ES (1) ES466892A1 (es)
FI (1) FI67483C (es)
FR (1) FR2381079A1 (es)
GB (1) GB1567294A (es)
GR (1) GR66100B (es)
HU (1) HU177685B (es)
IE (1) IE46408B1 (es)
IL (1) IL53978A (es)
IT (1) IT7848013A0 (es)
LU (1) LU79071A1 (es)
NL (1) NL7801240A (es)
NO (1) NO148838C (es)
NZ (1) NZ186399A (es)
PH (1) PH15263A (es)
PL (1) PL122299B1 (es)
PT (1) PT67663B (es)
SE (1) SE433170B (es)
ZA (1) ZA78913B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5900475A (en) * 1994-06-10 1999-05-04 Geltex Pharmaceuticals, Inc. Hydrophobic sequestrant for cholesterol depletion
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5929184A (en) * 1993-06-02 1999-07-27 Geltex Pharmaceuticals, Inc. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
US5709880A (en) * 1995-07-10 1998-01-20 Buckman Laboratories International, Inc. Method of making tabletized ionene polymers
EP0778027A3 (de) 1995-12-04 1998-04-01 Helmut Univ.-Prof. Dr. Wachter Verwendung von Kieselerde zur Herstellung von Arzneimitteln
JP4010585B2 (ja) * 1996-10-15 2007-11-21 久光製薬株式会社 陰イオン交換樹脂を含有する錠剤
US6203785B1 (en) 1996-12-30 2001-03-20 Geltex Pharmaceuticals, Inc. Poly(diallylamine)-based bile acid sequestrants
US6423754B1 (en) 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6726905B1 (en) 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
CN116925354B (zh) * 2023-07-20 2025-09-23 黑龙江省科学院石油化学研究院 一种高强度的聚酰亚胺气凝胶褶皱纸及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206115A1 (es) * 1973-06-11 1976-06-30 Merck & Co Inc Procedimiento para preparar un polimero lineal no ramificado y no reticulado
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol

Also Published As

Publication number Publication date
FR2381079A1 (fr) 1978-09-15
IL53978A0 (en) 1978-04-30
HU177685B (en) 1981-12-28
PL204642A1 (pl) 1979-06-04
DE2806707A1 (de) 1978-08-24
PL122299B1 (en) 1982-07-31
DK46578A (da) 1978-08-18
FI67483C (fi) 1985-04-10
NO148838B (no) 1983-09-19
NO780367L (no) 1978-08-18
IE46408B1 (en) 1983-06-01
AU518127B2 (en) 1981-09-17
IT7848013A0 (it) 1978-02-10
CH636012A5 (en) 1983-05-13
NO148838C (no) 1983-12-28
NZ186399A (en) 1980-11-28
AT363173B (de) 1981-07-10
IL53978A (en) 1981-03-31
BE863930A (fr) 1978-08-14
NL7801240A (nl) 1978-08-21
JPS53102958A (en) 1978-09-07
LU79071A1 (fr) 1978-09-28
GB1567294A (en) 1980-05-14
FI67483B (fi) 1984-12-31
CA1109395A (en) 1981-09-22
FI780296A7 (fi) 1978-08-18
ZA78913B (en) 1979-09-26
IE780332L (en) 1978-08-17
SE7801242L (sv) 1978-08-18
ATA87978A (de) 1980-12-15
PT67663B (en) 1980-03-03
AU3309978A (en) 1979-08-16
GR66100B (es) 1981-01-16
FR2381079B1 (es) 1981-09-11
PH15263A (en) 1982-11-02
PT67663A (en) 1978-03-01
SE433170B (sv) 1984-05-14

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202