ES466968A1 - Procedimiento para la preparacion de pirazolo -oxazepinas y de pirazolo-tiazepinas. - Google Patents

Procedimiento para la preparacion de pirazolo -oxazepinas y de pirazolo-tiazepinas.

Info

Publication number: ES466968A1
Authority: ES; Spain
Prior art keywords: group; carbon atoms; alcohol; formula; radical
Prior art date: 1977-02-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES466968A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hoechst AG

Original Assignee

Hoechst AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-19

Filing date

1978-02-14

Publication date

1978-10-01

1978-02-14 Application filed by Hoechst AG filed Critical Hoechst AG

1978-10-01 Publication of ES466968A1 publication Critical patent/ES466968A1/es

Status Expired legal-status Critical Current

Links

-1 Heterocyclic nitrogen compound Chemical class 0.000 title abstract 8
238000004519 manufacturing process Methods 0.000 title 1
229910017464 nitrogen compound Inorganic materials 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 21
125000003158 alcohol group Chemical group 0.000 abstract 8
125000003545 alkoxy group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
125000004429 atom Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 2
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
125000004283 imidazolin-2-yl group Chemical group [H]N1C(*)=NC([H])([H])C1([H])[H] 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 abstract 1
VRVRGVPWCUEOGV-UHFFFAOYSA-N 2-aminothiophenol Chemical compound NC1=CC=CC=C1S VRVRGVPWCUEOGV-UHFFFAOYSA-N 0.000 abstract 1
ZSNCQJKFJROFSD-UHFFFAOYSA-N C1=CNOC2=CN=NC2=C1 Chemical class C1=CNOC2=CN=NC2=C1 ZSNCQJKFJROFSD-UHFFFAOYSA-N 0.000 abstract 1
IAWSGYCQVBQFEW-UHFFFAOYSA-N C1=CNSC2=CN=NC2=C1 Chemical class C1=CNSC2=CN=NC2=C1 IAWSGYCQVBQFEW-UHFFFAOYSA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
150000008065 acid anhydrides Chemical class 0.000 abstract 1
230000001476 alcoholic effect Effects 0.000 abstract 1
150000001298 alcohols Chemical class 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
229910021529 ammonia Inorganic materials 0.000 abstract 1
CPEKAXYCDKETEN-UHFFFAOYSA-N benzoyl isothiocyanate Chemical compound S=C=NC(=O)C1=CC=CC=C1 CPEKAXYCDKETEN-UHFFFAOYSA-N 0.000 abstract 1
230000001588 bifunctional effect Effects 0.000 abstract 1
125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
150000001805 chlorine compounds Chemical class 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
DQMWMUMCNOJLSI-UHFFFAOYSA-N n-carbamothioylbenzamide Chemical compound NC(=S)NC(=O)C1=CC=CC=C1 DQMWMUMCNOJLSI-UHFFFAOYSA-N 0.000 abstract 1
125000002560 nitrile group Chemical group 0.000 abstract 1
NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ES466968A 1977-02-19 1978-02-14 Procedimiento para la preparacion de pirazolo -oxazepinas y de pirazolo-tiazepinas. Expired ES466968A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19772707269 DE2707269A1 (de)	1977-02-19	1977-02-19	Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung

Publications (1)

Publication Number	Publication Date
ES466968A1 true ES466968A1 (es)	1978-10-01

Family

ID=6001699

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES466968A Expired ES466968A1 (es)	1977-02-19	1978-02-14	Procedimiento para la preparacion de pirazolo -oxazepinas y de pirazolo-tiazepinas.

Country Status (6)

Country	Link
JP (1)	JPS53103498A (fr)
BE (1)	BE864111A (fr)
DE (1)	DE2707269A1 (fr)
ES (1)	ES466968A1 (fr)
FR (1)	FR2381054A1 (fr)
NL (1)	NL7801854A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4404137A (en) *	1979-10-16	1983-09-13	Lilly Industries Limited	Pyrazolo [3,4-b][1,5]benzodiazepine compounds
DE3122670A1 (de) *	1981-06-06	1982-12-23	Dr. Karl Thomae Gmbh, 7950 Biberach	"neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
US7799794B2 (en)	2000-06-28	2010-09-21	Merck Sharp & Dohme Corp.	Treatment for cardiovascular disease
WO2006121995A2 (fr)	2005-05-09	2006-11-16	Tap Pharmaceutical Products, Inc.	Methodes de traitement de la nephrolithiase
WO2012033941A1 (fr)	2010-09-10	2012-03-15	Takeda Pharmaceuticals North America, Inc.	Méthodes de traitement simultané à base de théophylline et de fébuxostat

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1532315A (fr) *	1966-02-23	1968-07-12	Abbott Lab	Procédé de préparation de benzoxazépines et benzothiazépines substituées et intermédiaires utilisés dans ce procédé

1977
- 1977-02-19 DE DE19772707269 patent/DE2707269A1/de active Pending
1978
- 1978-02-14 ES ES466968A patent/ES466968A1/es not_active Expired
- 1978-02-17 FR FR7804560A patent/FR2381054A1/fr not_active Withdrawn
- 1978-02-17 NL NL7801854A patent/NL7801854A/xx not_active Application Discontinuation
- 1978-02-18 JP JP1713978A patent/JPS53103498A/ja active Pending
- 1978-02-20 BE BE185296A patent/BE864111A/fr unknown

Also Published As

Publication number	Publication date
FR2381054A1 (fr)	1978-09-15
BE864111A (fr)	1978-08-21
JPS53103498A (en)	1978-09-08
NL7801854A (nl)	1978-08-22
DE2707269A1 (de)	1978-08-24

Publication	Publication Date	Title
ES444918A1 (es)	1977-11-01	Procedimiento para preparar imidazoles sustituidos y sus de-rivados.
GB1312536A (en)	1973-04-04	Hydantoin derivatives
ES391299A1 (es)	1975-11-01	Procedimiento para la preparacion de n-alil 2 - arilamino -imidazolinas (2) sustituidas.
ES405942A1 (es)	1975-07-01	Procedimiento para la preparacion de 2-fenilimino-imidazo- lidinas.
ES305661A1 (es)	1965-05-01	Procedimiento para la produccion de derivados de fenilciclopropano.
GB1273412A (en)	1972-05-10	Control of pests with cycloalkane derivatives of nitrated aryl compounds
ES466968A1 (es)	1978-10-01	Procedimiento para la preparacion de pirazolo -oxazepinas y de pirazolo-tiazepinas.
ES411341A1 (es)	1976-03-16	Procedimiento para la preparacion de compuestos heteroci- clicos sustituidos por un radical guanidinilideno.
ES462092A1 (es)	1978-12-01	Procedimiento para la obtencion de n-aril-(n'alquil y n'-ci-cloalquil)-tioureas.
ES384491A1 (es)	1974-02-16	Procedimiento para la obtencion de derivados de acetil- guanidina.
ES415021A1 (es)	1976-05-16	Un procedimiento para la preparacion de compuestos de tria-zina.
ES386586A1 (es)	1973-11-16	Un metodo para preparar nuevos derivados de 2-aminoindanos.
ES422472A1 (es)	1976-10-01	Procedimiento para preparar 2- (fenoxialquiltio) imidazo- les.
ES390163A1 (es)	1973-07-01	Procedimiento para la preparacion de amino-derivados de los acidos pirazolo (3,4-b) piridina-5-carboxilicos.
GB971245A (en)	1964-09-30	Method of preparation of heterocyclic compounds
ES440030A1 (es)	1977-02-16	Un procedimiento para preparar nuevos derivados de 2-ami- noindano.
ES450381A1 (es)	1977-12-01	Procedimiento para preparar derivados de acido indanacetico.
ES419019A1 (es)	1976-06-16	Procedimiento para la preparacion de compuestos polici- clicos.
JPS5626873A (en)	1981-03-16	Novel nnaminoalkylindole derivative* its manufacture and gastroointestinal tract movement trouble treating drug containing it
ES423745A1 (es)	1976-04-16	Procedimiento para preparar derivados de 2-aminoindano.
GB1469226A (en)	1977-04-06	Process for the preparation of 2-2-thienyl-ethylamine and derivatives thereof
ES312278A1 (es)	1965-07-16	Procedimiento para la produccion de amino-etilicos
ES393554A1 (es)	1974-11-16	Un procedimiento para la preparacion de derivados de tia- zol.
ES450586A1 (es)	1977-08-16	Procedimiento para preparar 1-azidoalquilimidazoles.
GB1032377A (en)	1966-06-08	Asymmetrical pyridoxolyl disulphides and their preparation