ES467953A1 - PROCEDURE FOR PREPARING PHARMACOLOGICALLY ACTIVE TRIAZINONES. - Google Patents

PROCEDURE FOR PREPARING PHARMACOLOGICALLY ACTIVE TRIAZINONES.

Info

Publication number
ES467953A1
ES467953A1 ES467953A ES467953A ES467953A1 ES 467953 A1 ES467953 A1 ES 467953A1 ES 467953 A ES467953 A ES 467953A ES 467953 A ES467953 A ES 467953A ES 467953 A1 ES467953 A1 ES 467953A1
Authority
ES
Spain
Prior art keywords
ring
optionally substituted
lower alkyl
bromine
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467953A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline & French Laboratories Ltd
Original Assignee
Smith Kline & French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline & French Laboratories Ltd filed Critical Smith Kline & French Laboratories Ltd
Publication of ES467953A1 publication Critical patent/ES467953A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for preparing pharmacologically active triazinones, of formula: (See formula) wherein Het'is a 2- or 4-imidazolyl ring optionally substituted by lower alkyl (preferably methyl), halogen (preferably chlorine or bromine), trifluoromethyl or hydroxymethyl, a 2-pyridyl ring optionally substituted by one or two groups (which may be the same or different) chosen from lower alkyl (preferably methyl), lower alkoxy (preferably methoxy), halogen (preferably chlorine or bromine), amino and hydroxy, a 2-pyridyl ring with a phenyl, carbocyclic or heterocyclic ring containing two atoms of oxygen fused thereto, a 2-thiazolyl ring, a 3-isothiazolyl ring optionally substituted by chlorine or bromine, a 3- (1,2,5) thiadiazolyl ring optionally substituted by chlorine or bromine, or a 2- (5 -amino-1,3,4-thiadiazolyl); Z'is sulfur or a methylene group; x is from 1 to 5; Y is a 1- or 2-naphthyl ring, a 2,3-dihydro-1,4-benzodioxynol ring or a 1,3-benzodioxolyl ring, a phenyl ring substituted with one or more alkyl, lower alkoxy, halogen, arylalkoxy groups, hydroxy, alkoxyalkoxy, trifluoromethyl, di (lower alkyl) amino, phenoxy, halophenoxy, alkoxyphenoxy, phenyl, halophenyl or alkoxyphenyl, a 5- or 6-membered heterocycle such as a pyridine, furan, thiophene, thiazole, oxazole, isothiazole, imidazole ring., pyrimidine, pyrazine or pyridazine, the ring of which is optionally substituted by lower alkyl, lower alkoxy or may have a benzene ring fused thereto, or when x is other than 1 Y may also be phenyl; characterized in that it comprises reacting a triazinone of the formula: (See formula) where x and Y are defined as above and Q is lower alkyl, thio, benzylthio or other grouping conveniently displaced by an amine, with tina amine of the formula: Het'-CH2Z'- (CH2) 2NH2 where Het'and Z' are defined as above. (Machine-translation by Google Translate, not legally binding)
ES467953A 1977-03-19 1978-03-17 PROCEDURE FOR PREPARING PHARMACOLOGICALLY ACTIVE TRIAZINONES. Expired ES467953A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB11757/77A GB1601132A (en) 1977-03-19 1977-03-19 Pharmacologically active triazinones

Publications (1)

Publication Number Publication Date
ES467953A1 true ES467953A1 (en) 1978-11-01

Family

ID=9992150

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467953A Expired ES467953A1 (en) 1977-03-19 1978-03-17 PROCEDURE FOR PREPARING PHARMACOLOGICALLY ACTIVE TRIAZINONES.

Country Status (20)

Country Link
AR (1) AR223643A1 (en)
BE (1) BE864992A (en)
BG (1) BG33157A3 (en)
CS (1) CS208746B2 (en)
DD (1) DD134522A5 (en)
DK (1) DK121978A (en)
EG (1) EG13240A (en)
ES (1) ES467953A1 (en)
FI (1) FI780629A7 (en)
GB (1) GB1601132A (en)
GR (1) GR66122B (en)
HU (1) HU175669B (en)
IT (1) IT1095458B (en)
NO (1) NO148556C (en)
PL (1) PL110686B1 (en)
PT (1) PT67687B (en)
SE (1) SE7803113L (en)
SU (1) SU733517A3 (en)
YU (1) YU65278A (en)
ZA (1) ZA78988B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
AU2192683A (en) * 1982-12-30 1984-07-05 Biomeasure Incorporated Pyrazolo(1,5-alpha)-1,3,5-triazines
GB0113343D0 (en) * 2001-06-01 2001-07-25 Bayer Ag Novel Heterocycles 2

Also Published As

Publication number Publication date
BG33157A3 (en) 1982-12-15
AR223643A1 (en) 1981-09-15
FI780629A7 (en) 1978-09-20
PT67687A (en) 1978-03-01
PL205382A1 (en) 1979-03-26
YU65278A (en) 1982-08-31
IT1095458B (en) 1985-08-10
NO148556B (en) 1983-07-25
DK121978A (en) 1978-09-20
CS208746B2 (en) 1981-09-15
SE7803113L (en) 1978-09-20
PT67687B (en) 1979-07-23
PL110686B1 (en) 1980-07-31
GR66122B (en) 1981-01-16
HU175669B (en) 1980-09-28
GB1601132A (en) 1981-10-28
SU733517A3 (en) 1980-05-05
NO148556C (en) 1983-11-02
IT7820754A0 (en) 1978-02-28
EG13240A (en) 1980-12-31
BE864992A (en) 1978-09-18
NO780970L (en) 1978-09-20
DD134522A5 (en) 1979-03-07
ZA78988B (en) 1979-06-27

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