ES467954A1 - Indoles - Google Patents

Indoles

Info

Publication number
ES467954A1
ES467954A1 ES467954A ES467954A ES467954A1 ES 467954 A1 ES467954 A1 ES 467954A1 ES 467954 A ES467954 A ES 467954A ES 467954 A ES467954 A ES 467954A ES 467954 A1 ES467954 A1 ES 467954A1
Authority
ES
Spain
Prior art keywords
formula
alkyl
substituted
benzyl
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES467954A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sauba & Roncales Labor SA
Original Assignee
Sauba & Roncales Labor SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sauba & Roncales Labor SA filed Critical Sauba & Roncales Labor SA
Publication of ES467954A1 publication Critical patent/ES467954A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedure to prepare piperazino-3-indoles, of general formula: **(See formula)** wherein A is a hydrogen atom, a carboxylic acid radical or an alkyl, alkylaminoalkyl, benzyl or phenyl group, substituted or unsubstituted; R1 is a hydrogen or chlorine atom or a lower alkyl, methoxy or hydroxy group; R2 is an alkyl, benzyl or phenyl group or a substituted or unsubstituted cyclic or heterocyclic group; and its pharmaceutically acceptable acid addition salts; characterized in that it comprises reacting an optionally substituted indolinone-3, of the formula: **(See formula)** wherein A and R1 are defined as above, with a piperazine derivative of the formula: **(See formula)** wherein R2 is defined as above, in a solvent medium. (Machine-translation by Google Translate, not legally binding)
ES467954A 1977-03-17 1978-03-17 Indoles Expired ES467954A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7707993A FR2421900A1 (en) 1977-03-17 1977-03-17 PIPERAZINO-3-INDOLES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS

Publications (1)

Publication Number Publication Date
ES467954A1 true ES467954A1 (en) 1978-11-01

Family

ID=9188218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES467954A Expired ES467954A1 (en) 1977-03-17 1978-03-17 Indoles

Country Status (4)

Country Link
DE (1) DE2811031C2 (en)
ES (1) ES467954A1 (en)
FR (1) FR2421900A1 (en)
GB (1) GB1570374A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2475898A1 (en) 1980-02-14 1981-08-21 Andre Buzas ANALGESIC MEDICINE CONTAINING 1- (3'-BENZOFURYL) -4-BENZYLPIPERAZINE AND PROCESS FOR PREPARING THE SAME
FR2524884A1 (en) * 1982-04-07 1983-10-14 Delalande Sa 1-Heterocyclyl piperazine, homo:piperazine and piperidine derivs. - useful as antihypertensive agents
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
JP2800953B2 (en) * 1990-07-06 1998-09-21 住友製薬株式会社 New imide derivatives
DK181190D0 (en) * 1990-07-30 1990-07-30 Lundbeck & Co As H 3-ARYL-INDOL OR 3-ARYL-INDAZOL DERIVATIVES
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
NZ243065A (en) 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
ES2063700B1 (en) * 1993-04-28 1995-07-16 Vita Invest Sa ACTIVE AGENT ON THE CENTRAL NERVOUS SYSTEM, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT.
WO2004106298A1 (en) * 2003-05-30 2004-12-09 Janssen Pharmaceutica N.V. Indole derivatives with an improved antipsychotic activity
ATE524461T1 (en) * 2006-10-27 2011-09-15 Boehringer Ingelheim Int NEW SUBSTITUTED PIPERIDYLPROPANTHIOLE
EP2079725B1 (en) * 2006-10-27 2011-12-14 Boehringer Ingelheim International GmbH Piperidyl-propane-thiol ccr3 modulators
CA2681162C (en) * 2007-03-15 2015-11-24 Novartis Ag Benzyl and pyridine derivatives as modulators of hedgehog pathway
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1135461B (en) * 1959-05-08 1962-08-30 Knoll Ag Process for the production of basic substituted phthalimidines
NL133995C (en) * 1965-08-21
DE2138865A1 (en) * 1970-08-15 1973-02-22 Sumitomo Chemical Co 3-INDOLYLPIPERAZINE, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS
US3751416A (en) * 1971-05-27 1973-08-07 American Cyanamid Co 3-(2-(4-phenyl-1-piperazinyl)-ethyl)indolines
FR2140260B1 (en) * 1971-06-07 1974-08-30 Delalande Sa
BE790679A (en) * 1971-11-03 1973-04-27 Ici Ltd INDOLE DERIVATIVES
FR2191895B1 (en) * 1972-07-17 1975-10-17 Bellon Labor Sa Roger

Also Published As

Publication number Publication date
FR2421900B1 (en) 1980-10-10
DE2811031A1 (en) 1978-09-21
DE2811031C2 (en) 1984-11-29
FR2421900A1 (en) 1979-11-02
GB1570374A (en) 1980-07-02

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