ES468874A1 - Procedimiento para preparar derivados de 2-(2,2-diarilal- quil)-1-azabiciclo (2,2,2) octano. - Google Patents

Procedimiento para preparar derivados de 2-(2,2-diarilal- quil)-1-azabiciclo (2,2,2) octano.

Info

Publication number
ES468874A1
ES468874A1 ES468874A ES468874A ES468874A1 ES 468874 A1 ES468874 A1 ES 468874A1 ES 468874 A ES468874 A ES 468874A ES 468874 A ES468874 A ES 468874A ES 468874 A1 ES468874 A1 ES 468874A1
Authority
ES
Spain
Prior art keywords
azabicyclo
octanes
substituted
compounds
pentenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES468874A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of ES468874A1 publication Critical patent/ES468874A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Procedimiento para preparar derivados de 2-(2,2-diarialquil)-1-azabiciclo[2,2,2]octano, de fórmula general (ver imagen I) en el que R y R' se eligen independientemente entre fenilo, piridilo, halofenilo monosustituido y alquilfenilo monosustituido, en donde el radical alquilo contiene de 1 a 4 átomos de carbono; R'' se elige entre un radical alquilo de 1 a 8 átomos de carbono, un radical alquenilo de 3 a 6 átomos de carbono, un radical cicloalquilo de 3 a 6 átomos de carbono, un radical cicloalquil-alquilo en donde la porción cicloalquilo contiene de 3 a 6 átomos de carbono y la porción alquilo contiene de 1 a 3 átomos de carbono, y un radical cicloalquenilo de 4 a 7 átomos de carbono; y n es un entero positivo de 1 a 3.
ES468874A 1977-04-18 1978-04-17 Procedimiento para preparar derivados de 2-(2,2-diarilal- quil)-1-azabiciclo (2,2,2) octano. Expired ES468874A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/788,189 US4125531A (en) 1977-04-18 1977-04-18 2-Substituted-1-azabicyclo[2.2.2]octanes

Publications (1)

Publication Number Publication Date
ES468874A1 true ES468874A1 (es) 1978-12-01

Family

ID=25143721

Family Applications (1)

Application Number Title Priority Date Filing Date
ES468874A Expired ES468874A1 (es) 1977-04-18 1978-04-17 Procedimiento para preparar derivados de 2-(2,2-diarilal- quil)-1-azabiciclo (2,2,2) octano.

Country Status (19)

Country Link
US (1) US4125531A (es)
JP (1) JPS53132596A (es)
AT (1) AT357553B (es)
AU (1) AU3516178A (es)
BE (1) BE866031A (es)
DE (1) DE2816633A1 (es)
DK (1) DK166978A (es)
ES (1) ES468874A1 (es)
FI (1) FI781161A7 (es)
FR (1) FR2387980A1 (es)
GB (1) GB1569249A (es)
IE (1) IE46737B1 (es)
IL (1) IL54519A0 (es)
NL (1) NL7804145A (es)
NO (1) NO781333L (es)
NZ (1) NZ186991A (es)
PT (1) PT67910B (es)
SE (1) SE7804307L (es)
ZA (1) ZA782212B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203989A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
JPH03135978A (ja) * 1989-08-08 1991-06-10 Merck Sharp & Dohme Ltd 置換ピリジン、その製法、処方並びに痴呆症における使用法
US5242930A (en) * 1991-02-11 1993-09-07 Merck Sharp & Dohme Ltd. Azabicyclic compounds, pharmaceutical compositions containing them and their use in therapy
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
HRP20150037T4 (hr) 2003-04-08 2022-09-02 Progenics Pharmaceuticals, Inc. Farmaceutske formulacije koje sadrže metilnaltrekson
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
CA2682129A1 (en) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Crystal forms and uses thereof
US8546418B2 (en) 2007-03-29 2013-10-01 Progenics Pharmaceuticals, Inc. Peripheral opioid receptor antagonists and uses thereof
PT2139890E (pt) 2007-03-29 2014-09-03 Wyeth Llc Antagonistas do receptor opióide periférico e respectivas utilizações
EP2240489A1 (en) 2008-02-06 2010-10-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506672A (en) * 1968-03-29 1970-04-14 Aldrich Chem Co Inc 2-(4,4'-dihalo)-benzhydryl-3-quinuclidinols
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4013667A (en) * 1976-03-08 1977-03-22 G. D. Searle & Co. 2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto

Also Published As

Publication number Publication date
US4125531A (en) 1978-11-14
NO781333L (no) 1978-10-19
JPS53132596A (en) 1978-11-18
DK166978A (da) 1978-10-19
ATA266178A (de) 1979-12-15
AT357553B (de) 1980-07-25
FR2387980A1 (fr) 1978-11-17
IE46737B1 (en) 1983-09-07
NZ186991A (en) 1979-12-11
ZA782212B (en) 1979-11-28
SE7804307L (sv) 1978-10-19
AU3516178A (en) 1979-10-25
DE2816633A1 (de) 1978-10-19
FI781161A7 (fi) 1978-10-19
PT67910A (en) 1978-05-01
PT67910B (en) 1979-11-14
BE866031A (fr) 1978-10-17
IE780745L (en) 1978-10-18
GB1569249A (en) 1980-06-11
NL7804145A (nl) 1978-10-20
IL54519A0 (en) 1978-07-31

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