ES469111A1 - Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos. - Google Patents

Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.

Info

Publication number: ES469111A1
Authority: ES; Spain
Prior art keywords: methyl; ethyl; substituent attached; pyridyl; dihydro
Prior art date: 1977-02-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES469111A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Dr Karl Thomae GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-03

Filing date

1978-04-25

Publication date

1978-11-16

1978-04-25 Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH

1978-11-16 Publication of ES469111A1 publication Critical patent/ES469111A1/es

Status Expired legal-status Critical Current

Links

125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 6
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 5
-1 methoxy, methyl Chemical group 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
230000001741 anti-phlogistic effect Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Chemical group 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Chemical group 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000007529 inorganic bases Chemical class 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000007530 organic bases Chemical class 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000000106 platelet aggregation inhibitor Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ES469111A 1977-02-03 1978-04-25 Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos. Expired ES469111A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19772704485 DE2704485A1 (de)	1977-02-03	1977-02-03	Neue 2,5-dihydro-1,2-thiazino eckige klammer auf 5,6-b eckige klammer zu indol-3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Publications (1)

Publication Number	Publication Date
ES469111A1 true ES469111A1 (es)	1978-11-16

Family

ID=6000267

Family Applications (5)

Application Number	Title	Priority Date	Filing Date
ES466555A Expired ES466555A1 (es)	1977-02-03	1978-02-02	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.
ES469113A Expired ES469113A1 (es)	1977-02-03	1978-04-25	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.
ES469111A Expired ES469111A1 (es)	1977-02-03	1978-04-25	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.
ES469112A Expired ES469112A1 (es)	1977-02-03	1978-04-25	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.
ES469110A Expired ES469110A1 (es)	1977-02-03	1978-04-25	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
ES466555A Expired ES466555A1 (es)	1977-02-03	1978-02-02	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.
ES469113A Expired ES469113A1 (es)	1977-02-03	1978-04-25	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
ES469112A Expired ES469112A1 (es)	1977-02-03	1978-04-25	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.
ES469110A Expired ES469110A1 (es)	1977-02-03	1978-04-25	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.

Country Status (35)

Country	Link
US (1)	US4137313A (es)
JP (1)	JPS5398998A (es)
AT (3)	AT355585B (es)
AU (1)	AU516178B2 (es)
BE (1)	BE863588A (es)
BG (1)	BG36499A3 (es)
CA (1)	CA1088064A (es)
CH (1)	CH639389A5 (es)
CS (1)	CS194195B2 (es)
DD (1)	DD134767A5 (es)
DE (1)	DE2704485A1 (es)
DK (1)	DK150517C (es)
ES (5)	ES466555A1 (es)
FI (1)	FI62097C (es)
FR (1)	FR2379542A1 (es)
GB (1)	GB1569238A (es)
GR (1)	GR64418B (es)
HK (1)	HK71383A (es)
HU (1)	HU175550B (es)
IE (1)	IE46185B1 (es)
IL (1)	IL53948A (es)
IT (1)	IT1105151B (es)
LU (1)	LU78974A1 (es)
MY (1)	MY8400283A (es)
NL (1)	NL7801183A (es)
NO (1)	NO148490C (es)
NZ (1)	NZ186374A (es)
PH (1)	PH13882A (es)
PL (1)	PL109705B1 (es)
PT (1)	PT67607B (es)
SE (1)	SE436749B (es)
SG (1)	SG48083G (es)
SU (1)	SU654173A3 (es)
YU (1)	YU24478A (es)
ZA (1)	ZA78630B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2838377A1 (de) *	1978-09-02	1980-03-20	Thomae Gmbh Dr K	Neue 4-hydroxy-2h eckige klammer auf 1 eckige klammer zu benzothieno eckige klammer auf 2,3-e eckige klammer zu -1,2- thiazin-3-carboxamid-1,1-dioxide sowie deren salze, deren verwendung und verfahren zu ihrer herstellung
AU5811280A (en)	1979-06-13	1980-12-18	F. Hoffmann-La Roche Ag	Thiazine derivatives
GR80576B (en) *	1983-10-17	1984-11-29	Fujisawa Pharmaceutical Co	Thiazine derivatives, process for preparation thereof and pharmaceutical composition comprising the same
US4683306A (en) *	1984-07-13	1987-07-28	Yuhan Corporation Co., Ltd.	Process for the preparation of 3,4-dihydro-2-substituted-2H-1,2-thiazine-carboxylic acid 1,1-dioxide derivatives
US6407124B1 (en)	1998-06-18	2002-06-18	Bristol-Myers Squibb Company	Carbon substituted aminothiazole inhibitors of cyclin dependent kinases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH588693A5 (es) *	1973-12-10	1977-06-15	Image Analysing Computers Ltd
IL47877A (en) *	1974-08-26	1978-10-31	Sparamedica Ag	Thienothiazine carboxamide derivatives,their manufacture and pharmaceutical compositions containing them
AT345847B (de) *	1974-11-08	1978-10-10	Thomae Gmbh Dr K	Verfahren zur herstellung neuer 4-hydroxy-2h- naphtho- (2,1-e)-1,2-thiazin-3-carboxamid-1,1-dioxid und deren salze

1977
- 1977-02-03 DE DE19772704485 patent/DE2704485A1/de not_active Withdrawn
- 1977-12-28 SE SE7714833A patent/SE436749B/sv not_active IP Right Cessation
1978
- 1978-01-09 AT AT11178A patent/AT355585B/de active
- 1978-01-17 BG BG038411A patent/BG36499A3/xx unknown
- 1978-01-27 IT IT47828/78A patent/IT1105151B/it active
- 1978-01-27 US US05/872,889 patent/US4137313A/en not_active Expired - Lifetime
- 1978-01-30 SU SU782571747A patent/SU654173A3/ru active
- 1978-01-31 CS CS78650A patent/CS194195B2/cs unknown
- 1978-02-01 PH PH20738A patent/PH13882A/en unknown
- 1978-02-01 IL IL53948A patent/IL53948A/xx unknown
- 1978-02-01 HU HU78TO1069A patent/HU175550B/hu unknown
- 1978-02-01 LU LU78974A patent/LU78974A1/de unknown
- 1978-02-01 FI FI780324A patent/FI62097C/fi not_active IP Right Cessation
- 1978-02-01 DD DD78203510A patent/DD134767A5/xx unknown
- 1978-02-01 GR GR55322A patent/GR64418B/el unknown
- 1978-02-02 DK DK048478A patent/DK150517C/da not_active IP Right Cessation
- 1978-02-02 PL PL1978204401A patent/PL109705B1/pl unknown
- 1978-02-02 NL NL7801183A patent/NL7801183A/xx not_active Application Discontinuation
- 1978-02-02 BE BE184854A patent/BE863588A/xx not_active IP Right Cessation
- 1978-02-02 YU YU00244/78A patent/YU24478A/xx unknown
- 1978-02-02 CA CA296,063A patent/CA1088064A/en not_active Expired
- 1978-02-02 ZA ZA00780630A patent/ZA78630B/xx unknown
- 1978-02-02 NO NO780370A patent/NO148490C/no unknown
- 1978-02-02 PT PT67607A patent/PT67607B/pt unknown
- 1978-02-02 ES ES466555A patent/ES466555A1/es not_active Expired
- 1978-02-02 JP JP1104478A patent/JPS5398998A/ja active Granted
- 1978-02-02 CH CH114778A patent/CH639389A5/de not_active IP Right Cessation
- 1978-02-02 NZ NZ186374A patent/NZ186374A/xx unknown
- 1978-02-02 AU AU32931/78A patent/AU516178B2/en not_active Expired
- 1978-02-02 GB GB4304/78A patent/GB1569238A/en not_active Expired
- 1978-02-03 FR FR7803158A patent/FR2379542A1/fr active Granted
- 1978-02-03 IE IE246/78A patent/IE46185B1/en unknown
- 1978-04-25 ES ES469113A patent/ES469113A1/es not_active Expired
- 1978-04-25 ES ES469111A patent/ES469111A1/es not_active Expired
- 1978-04-25 ES ES469112A patent/ES469112A1/es not_active Expired
- 1978-04-25 ES ES469110A patent/ES469110A1/es not_active Expired
1979
- 1979-04-11 AT AT269679A patent/AT355591B/de not_active IP Right Cessation
- 1979-04-11 AT AT269579A patent/AT355590B/de not_active IP Right Cessation
1983
- 1983-08-10 SG SG48083A patent/SG48083G/en unknown
- 1983-12-20 HK HK713/83A patent/HK71383A/xx unknown
1984
- 1984-12-30 MY MY283/84A patent/MY8400283A/xx unknown

Also Published As

Publication number	Publication date
CA1088064A (en)	1980-10-21
GB1569238A (en)	1980-06-11
MY8400283A (en)	1984-12-31
PT67607A (de)	1978-03-01
AU516178B2 (en)	1981-05-21
PL109705B1 (en)	1980-06-30
LU78974A1 (de)	1979-05-25
IL53948A0 (en)	1978-04-30
AT355590B (de)	1980-03-10
AU3293178A (en)	1979-08-09
FI780324A7 (fi)	1978-08-04
IT1105151B (it)	1985-10-28
ES469110A1 (es)	1978-11-16
IE780246L (en)	1978-08-03
FI62097B (fi)	1982-07-30
ES469113A1 (es)	1978-11-16
NO148490C (no)	1983-10-19
FR2379542A1 (fr)	1978-09-01
FR2379542B1 (es)	1982-12-03
NO148490B (no)	1983-07-11
ES466555A1 (es)	1978-10-01
JPS5398998A (en)	1978-08-29
AT355585B (de)	1980-03-10
CS194195B2 (en)	1979-11-30
DE2704485A1 (de)	1978-08-10
DK150517C (da)	1987-10-19
HU175550B (hu)	1980-08-28
IT7847828A0 (it)	1978-01-27
SG48083G (en)	1984-07-27
JPS6111235B2 (es)	1986-04-01
PL204401A1 (pl)	1979-04-09
DK48478A (da)	1978-08-04
NZ186374A (en)	1980-03-05
ATA11178A (de)	1979-08-15
ES469112A1 (es)	1978-11-16
DD134767A5 (de)	1979-03-21
SU654173A3 (ru)	1979-03-25
SE436749B (sv)	1985-01-21
NO780370L (no)	1978-08-04
PH13882A (en)	1980-10-27
IL53948A (en)	1980-10-26
GR64418B (en)	1980-03-21
CH639389A5 (de)	1983-11-15
ATA269579A (de)	1979-08-15
AT355591B (de)	1980-03-10
BE863588A (fr)	1978-08-02
FI62097C (fi)	1982-11-10
BG36499A3 (bg)	1984-11-15
US4137313A (en)	1979-01-30
HK71383A (en)	1983-12-30
SE7714833L (sv)	1978-08-04
PT67607B (de)	1980-03-03
IE46185B1 (en)	1983-03-23
DK150517B (da)	1987-03-16
NL7801183A (nl)	1978-08-07
YU24478A (en)	1982-10-31
ZA78630B (en)	1979-10-31
ATA269679A (de)	1979-08-15

Legal Events

Date	Code	Title	Description
1999-01-01	FD1A	Patent lapsed	Effective date: 19981103

Publication	Publication Date	Title
FI963238A0 (fi)	1996-08-19	Heteroaromaattisia oksatsoli yhdisteitä ja niiden käyttö
ES8505652A1 (es)	1985-06-01	Procedimiento para preparar nuevas 1-bencil-aminoalquil-pirrolidinonas
KR930005992A (ko)	1993-04-20	루코트리엔 생합성 억제제
FI841759A0 (fi)	1984-05-03	Foerfarande foer framstaellning av nya fluoralkoxifoereningar.
FI955685A0 (fi)	1995-11-24	Uusia tiatsolidiinidioneja ja näitä sisältäviä lääkkeitä
JP2005537323A5 (es)	2006-06-22
DK160275C (da)	1991-07-22	Analogifremgangsmaade til fremstilling af 2-(2-(2,3-dihydrobenzofuranyl))-2-imidazolinderivater
SE7710873L (sv)	1978-03-30	Nya 1h-pyrazolo(3,4-b)pyridiner
NO156286C (no)	1987-08-26	Analogifremgangsmaate for fremstilling av terapeutisk virksomme benzamidderivater.
ES469111A1 (es)	1978-11-16	Procedimiento para la preparacion de nuevos 2,5-dihidro-1,2-tiazino (5,6-b)indol-3-carboxamido-1,1-dioxidos.
ATE111460T1 (de)	1994-09-15	2-(aminoalkyl)-5-(arylalkyl)1,3-dioxanderivate, ihre herstellung und ihre anwendung in der therapeutik.
KR880003920A (ko)	1988-05-31	피리다지논 유도체
SE7709158L (sv)	1978-02-15	Nya substituerade 2-fenylaminoimidazolin-(2)-er, syraadditionssalter derav, lekemedel som innehaller dessa och forfarande for framstellning derav
NO171786C (no)	1993-05-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater
SE7606847L (sv)	1976-12-28	10-/3(4-(p-fluorobenzoyl)piperidinyl)propyl/fenotiaziner
NO163814C (no)	1990-07-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-substituerte 4-hydroksymetyl-pyrrolidinon-derivater.
NO151465C (no)	1985-04-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater og syreaddisjonssalter derav
RU96103373A (ru)	1998-03-27	Замещенные арилтиоалкилтиопиридины
AR013889A1 (es)	2001-01-31	Nuevos derivados del acido 4-(1-piperazinil)-benzoico, procedimiento para obtenerlos y composiciones farmaceuticas que lo contienen.
ES421767A2 (es)	1977-07-01	Un procedimiento para la preparacion de acidos 5-sulfamil- benzoicos sustituidos en la posicion 2.
MX25035A (es)	1994-01-31	Derivados de mercaptoacilo y mercaptano de trifluorometilo y procedimiento para su preparacion.
DK531080A (da)	1981-06-15	Fremgangsmaade til fremstilling af substituerede 2-phenylamino-imidazoliner eller syreadditionssalte deraf
MXPA04000620A (es)	2004-06-25	Uso de derivados de tiazol para elaboracion de medicamento para tratamiento de enfermedad pulmonar obstructiva cronica.
NO803862L (no)	1981-06-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenylaminoimidazolin-derivater
SE7906093L (sv)	1980-01-14	Nya substituerade 4h-s-triazolo(3,4c)tieno(2,3e)-1,4-diazepiner, forfaranden for framstellning derav och farmaceutiska kompositioner