ES469285A1 - Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas - Google Patents
Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinasInfo
- Publication number
- ES469285A1 ES469285A1 ES469285A ES469285A ES469285A1 ES 469285 A1 ES469285 A1 ES 469285A1 ES 469285 A ES469285 A ES 469285A ES 469285 A ES469285 A ES 469285A ES 469285 A1 ES469285 A1 ES 469285A1
- Authority
- ES
- Spain
- Prior art keywords
- cephalosporins
- oxa
- dethia
- arylmalonamido
- broad
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title 1
- -1 3-thienyl phenyl Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- WWYDYZMNFQIYPT-UHFFFAOYSA-N ru78191 Chemical compound OC(=O)C(C(O)=O)C1=CC=CC=C1 WWYDYZMNFQIYPT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
En la presente invención se han preparado ahora varias 1-oxadestiacefalo sporinas estrechamente relacionadas con las (1-tia)-cefalo sporinas conocidas. Contrariamente a los informes que sugieren que sus 1-oxacefalo sporinas racémicas mostraban alrededor de la mitad de la potencia de la (1-tia)cefalo sporinas, los productos ópticamente activos preparados en la presente invención fueron de alrededor de 4 a 8 veces más activos que las correspondientes (1-tia)cefalo sporinas en cuanto a sus propiedades antibacterianas. Sin embargo, el anillo de beta-lactama de las 1-oxadestiacefalo sporinas era menos estable para uso como medicamentos clínicos que el de las (1-tia)cefalo sporinas. Los compuestos seleccionados de entre los compuestos ópticamente activos preparados en la presente invención, resuelven la deficiencia citada de las 1-oxadestiacefalo sporinas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3340176A JPS52122386A (en) | 1976-03-25 | 1976-03-25 | Cephalosporin analogous compounds as antibacterials |
| JP5029576A JPS52133997A (en) | 1976-04-30 | 1976-04-30 | Cephalosporin antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES469285A1 true ES469285A1 (es) | 1979-09-16 |
Family
ID=26372085
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES457174A Expired ES457174A1 (es) | 1976-03-25 | 1977-03-24 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
| ES469287A Expired ES469287A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas |
| ES469285A Expired ES469285A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas |
| ES469284A Expired ES469284A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
| ES469286A Expired ES469286A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar sales de arilmalonamido-1- oxadestiacefalosporinas |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES457174A Expired ES457174A1 (es) | 1976-03-25 | 1977-03-24 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
| ES469287A Expired ES469287A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES469284A Expired ES469284A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar arilmalonamido-1-oxadestiace-falosporinas. |
| ES469286A Expired ES469286A1 (es) | 1976-03-25 | 1978-04-28 | Un procedimiento para preparar sales de arilmalonamido-1- oxadestiacefalosporinas |
Country Status (19)
| Country | Link |
|---|---|
| AR (1) | AR224606A1 (es) |
| BG (1) | BG31074A3 (es) |
| CY (1) | CY1158A (es) |
| DD (1) | DD129792A5 (es) |
| DE (1) | DE2713370C2 (es) |
| DK (1) | DK161331C (es) |
| ES (5) | ES457174A1 (es) |
| GR (1) | GR61146B (es) |
| HK (1) | HK46882A (es) |
| HU (1) | HU172720B (es) |
| IE (1) | IE44794B1 (es) |
| IL (1) | IL51743A (es) |
| MX (1) | MX4348E (es) |
| NO (2) | NO158505C (es) |
| NZ (1) | NZ183687A (es) |
| PT (1) | PT66346B (es) |
| RO (2) | RO78228A (es) |
| SE (1) | SE443143B (es) |
| YU (2) | YU44039B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU514377B2 (en) * | 1977-02-15 | 1981-02-05 | Shionogi & Co., Ltd. | l-OXADETHIACEPHAM COMPOUNDS |
| US4252953A (en) * | 1979-05-01 | 1981-02-24 | Eli Lilly And Company | Antibiotic crystalline epimer |
| JPS60123490A (ja) * | 1983-12-07 | 1985-07-02 | Shionogi & Co Ltd | マロニルオキサセフェムカルボン酸誘導体 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL178005C (nl) * | 1972-11-06 | 1986-01-02 | Merck & Co Inc | Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum. |
| US3962232A (en) * | 1973-11-05 | 1976-06-08 | Eli Lilly And Company | 7-methoxycephalosporins |
| GB1449420A (en) * | 1973-11-26 | 1976-09-15 | Sankyo Co | 7alpha-methoxycephalosporing derivatives |
-
1977
- 1977-03-23 CY CY1158A patent/CY1158A/xx unknown
- 1977-03-23 SE SE7703325A patent/SE443143B/xx not_active IP Right Cessation
- 1977-03-23 NO NO771023A patent/NO158505C/no unknown
- 1977-03-23 GR GR53086A patent/GR61146B/el unknown
- 1977-03-24 IE IE622/77A patent/IE44794B1/en not_active IP Right Cessation
- 1977-03-24 PT PT66346A patent/PT66346B/pt unknown
- 1977-03-24 RO RO7799076A patent/RO78228A/ro unknown
- 1977-03-24 ES ES457174A patent/ES457174A1/es not_active Expired
- 1977-03-24 DK DK131277A patent/DK161331C/da not_active IP Right Cessation
- 1977-03-24 NZ NZ183687A patent/NZ183687A/xx unknown
- 1977-03-24 DD DD7700198053A patent/DD129792A5/xx unknown
- 1977-03-24 HU HU77SI00001565A patent/HU172720B/hu not_active IP Right Cessation
- 1977-03-24 RO RO7789781A patent/RO71742A/ro unknown
- 1977-03-24 BG BG035796A patent/BG31074A3/xx unknown
- 1977-03-25 MX MX775582U patent/MX4348E/es unknown
- 1977-03-25 IL IL51743A patent/IL51743A/xx unknown
- 1977-03-25 AR AR266992A patent/AR224606A1/es active
- 1977-03-25 DE DE2713370A patent/DE2713370C2/de not_active Expired - Lifetime
-
1978
- 1978-04-28 ES ES469287A patent/ES469287A1/es not_active Expired
- 1978-04-28 ES ES469285A patent/ES469285A1/es not_active Expired
- 1978-04-28 ES ES469284A patent/ES469284A1/es not_active Expired
- 1978-04-28 ES ES469286A patent/ES469286A1/es not_active Expired
-
1982
- 1982-11-11 HK HK468/82A patent/HK46882A/xx unknown
-
1983
- 1983-08-23 YU YU1738/83A patent/YU44039B/xx unknown
- 1983-08-23 YU YU1737/83A patent/YU44038B/xx unknown
-
1986
- 1986-05-28 NO NO862107A patent/NO862107L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1158A (en) | 1983-01-28 |
| NO771023L (no) | 1977-09-27 |
| DE2713370C2 (de) | 1994-04-21 |
| HK46882A (en) | 1982-11-19 |
| YU44039B (en) | 1990-02-28 |
| YU173883A (en) | 1983-12-31 |
| DK131277A (da) | 1977-09-26 |
| ES469286A1 (es) | 1979-09-16 |
| DK161331B (da) | 1991-06-24 |
| GR61146B (en) | 1978-09-27 |
| MX4348E (es) | 1982-04-05 |
| AR224606A1 (es) | 1981-12-30 |
| NO862107L (no) | 1977-09-27 |
| ES469284A1 (es) | 1978-11-16 |
| RO78228A (ro) | 1982-02-01 |
| ES457174A1 (es) | 1978-08-16 |
| BG31074A3 (en) | 1981-10-15 |
| NZ183687A (en) | 1979-01-11 |
| IE44794L (en) | 1977-09-25 |
| DD129792A5 (de) | 1978-02-08 |
| IL51743A (en) | 1980-10-26 |
| IE44794B1 (en) | 1982-04-07 |
| ES469287A1 (es) | 1979-09-16 |
| SE7703325L (sv) | 1977-09-26 |
| DE2713370A1 (de) | 1977-09-29 |
| NO158505B (no) | 1988-06-13 |
| DK161331C (da) | 1991-12-09 |
| NO158505C (no) | 1988-09-21 |
| YU173783A (en) | 1983-12-31 |
| SE443143B (sv) | 1986-02-17 |
| PT66346A (en) | 1977-04-01 |
| PT66346B (en) | 1978-08-16 |
| YU44038B (en) | 1990-02-28 |
| RO71742A (ro) | 1982-02-26 |
| HU172720B (hu) | 1978-11-28 |
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