ES469424A1 - Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o ma 144-m2. - Google Patents

Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o ma 144-m2.

Info

Publication number
ES469424A1
ES469424A1 ES469424A ES469424A ES469424A1 ES 469424 A1 ES469424 A1 ES 469424A1 ES 469424 A ES469424 A ES 469424A ES 469424 A ES469424 A ES 469424A ES 469424 A1 ES469424 A1 ES 469424A1
Authority
ES
Spain
Prior art keywords
case
antitumor antibiotics
solvent system
hydrides
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES469424A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES469424A1 publication Critical patent/ES469424A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/48—Streptomyces antibioticus ; Actinomyces antibioticus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces
    • Y10S435/888—Streptomyces antibioticus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Un procedimiento para la producción de los antibióticos antitumorales MA 144-M1 o MA 144-M2 de fórmula general **(Fórmula)** donde R representa un átomo de hidrógeno en el caso de MA 144- M1 o un grupo hidroxilo en el caso de MA 144-M2 o una sal de adición ácida, no tóxica de los mismos, cuyo procedimiento comprende a) reducir químicamente aclacinomicina A en el caso de MA 144- M1 o cinerrubina A en el caso de MA 144-M2, con un agente reductor seleccionado entre el grupo formado por borohidruro de sodio, hidruros de litio e hidruros de aluminio en un sistema disolvente único o en un sistema disolvente mixto, y b) opcionalmente, recuperar el MA 144-M1 o el MA 144-M2 de la mezcla de reacción con o sin salificación.
ES469424A 1976-04-07 1978-05-03 Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o ma 144-m2. Expired ES469424A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3968876A JPS52136159A (en) 1976-04-07 1976-04-07 Anti/malignanttumor containing the same as active ingredients

Publications (1)

Publication Number Publication Date
ES469424A1 true ES469424A1 (es) 1979-04-01

Family

ID=12559990

Family Applications (3)

Application Number Title Priority Date Filing Date
ES475579A Expired ES475579A1 (es) 1976-04-07 1977-04-05 Un procedimiento para la produccion de los antibioticos an- titumorales ma 144-m1 yno ma 144 m2.
ES469423A Expired ES469423A1 (es) 1976-04-07 1978-05-03 Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o 144-m2.
ES469424A Expired ES469424A1 (es) 1976-04-07 1978-05-03 Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o ma 144-m2.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES475579A Expired ES475579A1 (es) 1976-04-07 1977-04-05 Un procedimiento para la produccion de los antibioticos an- titumorales ma 144-m1 yno ma 144 m2.
ES469423A Expired ES469423A1 (es) 1976-04-07 1978-05-03 Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o 144-m2.

Country Status (11)

Country Link
US (2) US4144329A (es)
JP (1) JPS52136159A (es)
BE (1) BE853203A (es)
CA (1) CA1097238A (es)
DE (1) DE2715255C3 (es)
DK (1) DK146342C (es)
ES (3) ES475579A1 (es)
FR (1) FR2347381A1 (es)
GB (1) GB1563432A (es)
NL (1) NL168557C (es)
SE (1) SE436758B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4123608A (en) * 1977-07-18 1978-10-31 Bristol-Myers Company Antibiotic compound
ZA802929B (en) * 1979-05-22 1981-05-27 Hoffmann La Roche Novel tetracyclic compounds and process for the preparation thereof
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
EP0030255B1 (en) * 1979-09-07 1986-01-29 Sanraku Incorporated 2-hydroxyaclacinomycin a, pharmaceutical composition containing it; 2-hydroxyaclavinone and fermentative process for preparing same
JPS5767518A (en) * 1980-09-17 1982-04-24 Yamasa Shoyu Co Ltd Radiosensitizing agent or agent for increasing effect of radiomimetic substance
CH648327A5 (de) * 1980-10-16 1985-03-15 Hoffmann La Roche Anthracycline.
CA1187434A (en) * 1981-08-11 1985-05-21 Akihiro Yoshimoto Anthracycline antibiotics and their preparation method
JPS6133194A (ja) * 1984-07-25 1986-02-17 Sanraku Inc 新規アントラサイクリン抗生物質
US20050208037A1 (en) * 2003-10-21 2005-09-22 Board Of Regents, The University Of Texas System Thioredoxin increases redox-cycling of anticancer agents thereby sensitizes cancer cells to apoptosis
CN104644631A (zh) * 2015-01-31 2015-05-27 云南省第一人民医院 新乌头碱对k562细胞生物学特性的改变

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB846130A (en) 1956-03-23 1960-08-24 Ciba Ltd New antibiotic and derivatives and salts thereof, preparations containing the same and process for the manufacture of these substances
US3864480A (en) * 1974-05-06 1975-02-04 Merck & Co Inc Cinerubin A and B As Antiparasitic Agents
JPS5134915B2 (es) * 1974-07-27 1976-09-29
JPS5323961A (en) * 1976-08-16 1978-03-06 Microbial Chem Res Found Antitumors

Also Published As

Publication number Publication date
CA1097238A (en) 1981-03-10
DE2715255B2 (de) 1979-01-04
US4144329A (en) 1979-03-13
DK146342B (da) 1983-09-12
JPS5438100B2 (es) 1979-11-19
DE2715255C3 (de) 1979-08-30
SE436758B (sv) 1985-01-21
DK146342C (da) 1984-04-09
JPS52136159A (en) 1977-11-14
ES469423A1 (es) 1979-04-01
ES475579A1 (es) 1978-08-01
FR2347381A1 (fr) 1977-11-04
GB1563432A (en) 1980-03-26
NL168557C (nl) 1982-04-16
DE2715255A1 (de) 1977-11-10
BE853203A (fr) 1977-08-01
NL7703753A (nl) 1977-10-11
FR2347381B1 (es) 1980-10-17
SE7703760L (sv) 1977-10-08
DK152977A (da) 1977-10-08
US4219622A (en) 1980-08-26

Similar Documents

Publication Publication Date Title
ES469424A1 (es) Un procedimiento para la produccion de los antibioticos antitumorales ma 144-m1 o ma 144-m2.
KR850005452A (ko) 항생물질 화합물의 제조방법
JPS5265259A (en) Synthesis of 16beta-alkylestradiol or its 17-esters
AT339870B (de) Schlaufen-reaktor fur chemische reaktionen u.dgl.
ES417099A1 (es) Procedimiento de fabricacion de nuevos agentes oxidantes y secuestrantes.
CA940276A (en) Sulfur recovery from acid gases containing hydrogen sulfide
JPS51136622A (en) Process for preparation of isocyanic acid derivatives
JPS51112124A (en) Card lock release mechanism
KR900009673A (ko) 고순도의 모노알킬아르신 및 디알킬아르신의 화학적 제조방법 및 정제된 모노-및 디-알킬아르신
ES409350A1 (es) Procedimiento para preparar composiciones solidas extingui-doras del fuego.
JPS5257128A (en) Process for p-phenylenediamine
JPS5277003A (en) Stabilization process of peroxyketones
JPS5383713A (en) Cassette mounting and demounting device
JPS52108928A (en) Production of alkyl carbazate
JPS51131900A (en) A method for purifying stevioside
JPS5215946A (en) Generator utilizing temperature difference
JPS51120993A (en) Explosive proof apparatus for liquid hydrogen
JPS51151694A (en) Purification apparatus for rare gas
JPS5217443A (en) Process for preparation of aromatic urethanes
JPS51121489A (en) Display apparatus
JPS5348975A (en) Preparation of sparation membrane
JPS52128881A (en) Removal of water contained in organic solvent
JPS52719A (en) Process for recovering palladium
JPS51127097A (en) Method for purifying flavine-adenine dinucleotide
JPS51125013A (en) Process for preparation of oximes

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202