ES469528A1 - Mejoras en un procedimiento para la obtencion de acido 7- amino-3-(((2-metil-1,3,4-tiadiazol-5-il)-tio)-metil)-3-cefem-4-carboxilico - Google Patents
Mejoras en un procedimiento para la obtencion de acido 7- amino-3-(((2-metil-1,3,4-tiadiazol-5-il)-tio)-metil)-3-cefem-4-carboxilicoInfo
- Publication number
- ES469528A1 ES469528A1 ES469528A ES469528A ES469528A1 ES 469528 A1 ES469528 A1 ES 469528A1 ES 469528 A ES469528 A ES 469528A ES 469528 A ES469528 A ES 469528A ES 469528 A1 ES469528 A1 ES 469528A1
- Authority
- ES
- Spain
- Prior art keywords
- methyl
- cephem
- thiadiazol
- thio
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HJSGHKMSDOLGJJ-IOJJLOCKSA-N (6r)-7-amino-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1C(C)=NN=C1SCC1=C(C(O)=O)N2C(=O)C(N)[C@H]2SC1 HJSGHKMSDOLGJJ-IOJJLOCKSA-N 0.000 title 1
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 abstract 2
- -1 (2-methyl-1,3,4-thiadiazol-5-yl)thio Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000004042 decolorization Methods 0.000 abstract 1
- JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 abstract 1
- 235000010265 sodium sulphite Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Mejoras en un procedimiento para la obtención de ácido 7-amino-3-(((2-metil-1,3,4-tiadiazol-5-il)-tio)-metil)-3-cefem-4- carboxílico o una sal del mismo, libres de impurezas coloreadas, por reacción de desplazamiento nucleofilico del grupo acetoxi del ácido 7-amino-cefalosporánico con 5-metil-1,3,4-tiadiazol-2-tiol en una solución acuosa, cuya mejora consisten en tratar dicho ácido 7-amino-3(((2-metil-1,3,4-tiadiazol-5-il)-tio)-metil)-3-cefem-4-carboxílico o una sal del mismo con un agente reductor seleccionado del grupo formado por sulfito sódico y ditionito sódico simultánea o posteriormente a su obtención y recuperar dicho ácido o una sal del mismo decolorado de la solución.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/795,464 US4115645A (en) | 1977-05-10 | 1977-05-10 | Decolorizing process for 7-amino-3-(((2-methyl-1,3,4-thiadiazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES469528A1 true ES469528A1 (es) | 1979-09-16 |
Family
ID=25165569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES469528A Expired ES469528A1 (es) | 1977-05-10 | 1978-05-05 | Mejoras en un procedimiento para la obtencion de acido 7- amino-3-(((2-metil-1,3,4-tiadiazol-5-il)-tio)-metil)-3-cefem-4-carboxilico |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4115645A (es) |
| JP (1) | JPS53141291A (es) |
| ES (1) | ES469528A1 (es) |
| GB (1) | GB1598007A (es) |
| IE (1) | IE46635B1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040014498A (ko) * | 2001-04-19 | 2004-02-14 | 바이오퍼마 무르시아, 에스.에이. | 세팔로스포린 유도체의 제조 방법 |
| US20030135041A1 (en) * | 2002-01-04 | 2003-07-17 | Orchid Chemicals & Pharmaceuticals Limited, India | Synthesis of ceftiofur intermediate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1012943A (en) * | 1961-05-16 | 1965-12-15 | Glaxo Lab Ltd | Improvements in or relating to antibiotics |
| CH527215A (de) * | 1967-04-15 | 1972-08-31 | Fujisawa Pharmaceutical Co | Verfahren zur Herstellung von 3,7-disubstituierten Cephalosporinderivaten |
| BE809060A (fr) * | 1972-12-26 | 1974-06-21 | Lilly Co Eli | Stabilisation de la coloration d'une solution parenterale de cephalosporine |
| US3979383A (en) * | 1975-03-07 | 1976-09-07 | Eli Lilly And Company | Purification process for 7-aminocephalosporins |
-
1977
- 1977-05-10 US US05/795,464 patent/US4115645A/en not_active Expired - Lifetime
-
1978
- 1978-04-21 JP JP4831578A patent/JPS53141291A/ja active Pending
- 1978-05-04 GB GB17627/78A patent/GB1598007A/en not_active Expired
- 1978-05-05 ES ES469528A patent/ES469528A1/es not_active Expired
- 1978-05-08 IE IE924/78A patent/IE46635B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE46635B1 (en) | 1983-08-10 |
| IE780924L (en) | 1978-11-10 |
| JPS53141291A (en) | 1978-12-08 |
| GB1598007A (en) | 1981-09-16 |
| US4115645A (en) | 1978-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000301 |