ES469624A1 - Triazolothienodiazepines - Google Patents
TriazolothienodiazepinesInfo
- Publication number
- ES469624A1 ES469624A1 ES469624A ES469624A ES469624A1 ES 469624 A1 ES469624 A1 ES 469624A1 ES 469624 A ES469624 A ES 469624A ES 469624 A ES469624 A ES 469624A ES 469624 A1 ES469624 A1 ES 469624A1
- Authority
- ES
- Spain
- Prior art keywords
- ammonia
- well
- vii
- halide
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 229910021529 ammonia Inorganic materials 0.000 abstract 2
- -1 sulphur halide Chemical class 0.000 abstract 2
- 150000004911 1,4-diazepines Chemical class 0.000 abstract 1
- WXLCDTBTIVJDCE-UHFFFAOYSA-N 1,4-oxazepine Chemical compound O1C=CC=NC=C1 WXLCDTBTIVJDCE-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 230000002082 anti-convulsion Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000003578 releasing effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
The 1-substituted 8-iodo-6-phenyl-4H-s-triazolo[3,4c]thieno[2,3e]1,4-diazepines of the formula I, as well as their physiologically tolerated acid addition salts, are prepared by cleaving a 4,1-oxazepine of the formula VII at the oxygen atom by treatment with a strong mineral acid, adding a phosphorus or sulphur halide to the hydro halide which forms, reacting the dihalide thus obtained with ammonia or substances giving rise to ammonia, and dehydrogenating the product. The substituents in the formulae I and VII have the meanings given in Patent Claim 1. Further preparation processes are given in Patent Claims 7 to 11 and 13. The compounds exhibit valuable therapeutic properties, in particular tranquillising, tension-releasing and sedative activity, as well as an intensive anticonvulsive effect, in association with extraordinarily low toxicity. In addition, they can be employed for improving feed uptake in mammals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19772703304 DE2703304A1 (en) | 1977-01-18 | 1977-01-27 | Anxiolytic and sedative triazolo-thieno-diazepine(s) - with 8-iodo-6-phenyl substituents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES469624A1 true ES469624A1 (en) | 1978-12-16 |
Family
ID=5999679
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466365A Expired ES466365A1 (en) | 1977-01-27 | 1978-01-26 | Triazolothienodiazepines |
| ES469624A Expired ES469624A1 (en) | 1977-01-27 | 1978-05-09 | Triazolothienodiazepines |
| ES469626A Expired ES469626A1 (en) | 1977-01-27 | 1978-05-09 | Triazolothienodiazepines |
| ES469625A Expired ES469625A1 (en) | 1977-01-27 | 1978-05-09 | Triazolothienodiazepines |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466365A Expired ES466365A1 (en) | 1977-01-27 | 1978-01-26 | Triazolothienodiazepines |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES469626A Expired ES469626A1 (en) | 1977-01-27 | 1978-05-09 | Triazolothienodiazepines |
| ES469625A Expired ES469625A1 (en) | 1977-01-27 | 1978-05-09 | Triazolothienodiazepines |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5395998A (en) |
| AT (1) | AT358049B (en) |
| AU (1) | AU517925B2 (en) |
| BE (1) | BE863365A (en) |
| CH (1) | CH636878A5 (en) |
| DK (1) | DK39378A (en) |
| ES (4) | ES466365A1 (en) |
| FI (1) | FI780156A7 (en) |
| FR (1) | FR2378784A1 (en) |
| GB (1) | GB1586532A (en) |
| IE (1) | IE46501B1 (en) |
| IT (1) | IT1102803B (en) |
| LU (1) | LU78948A1 (en) |
| NL (1) | NL7800993A (en) |
| NO (1) | NO780294L (en) |
| SE (1) | SE7801001L (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT338799B (en) * | 1974-03-02 | 1977-09-12 | Boehringer Sohn Ingelheim | PROCESS FOR PREPARING NEW SUBSTITUTED 6-ARYL-4H-S-TRIAZOLO- (3,4C) -THIENO- (2,3E) -1,4-DIAZEPINE AND THEIR SALTS |
-
1978
- 1978-01-16 AT AT27178A patent/AT358049B/en not_active IP Right Cessation
- 1978-01-18 FI FI780156A patent/FI780156A7/en not_active Application Discontinuation
- 1978-01-24 CH CH74178A patent/CH636878A5/en not_active IP Right Cessation
- 1978-01-25 IT IT47789/78A patent/IT1102803B/en active
- 1978-01-26 GB GB3221/78A patent/GB1586532A/en not_active Expired
- 1978-01-26 BE BE184672A patent/BE863365A/en not_active IP Right Cessation
- 1978-01-26 ES ES466365A patent/ES466365A1/en not_active Expired
- 1978-01-26 SE SE7801001A patent/SE7801001L/en unknown
- 1978-01-26 NO NO780294A patent/NO780294L/en unknown
- 1978-01-26 DK DK39378A patent/DK39378A/en unknown
- 1978-01-26 AU AU32767/78A patent/AU517925B2/en not_active Expired
- 1978-01-26 LU LU78948A patent/LU78948A1/en unknown
- 1978-01-26 JP JP780678A patent/JPS5395998A/en active Pending
- 1978-01-27 NL NL7800993A patent/NL7800993A/en not_active Application Discontinuation
- 1978-01-27 FR FR7802329A patent/FR2378784A1/en active Granted
- 1978-01-27 IE IE190/78A patent/IE46501B1/en unknown
- 1978-05-09 ES ES469624A patent/ES469624A1/en not_active Expired
- 1978-05-09 ES ES469626A patent/ES469626A1/en not_active Expired
- 1978-05-09 ES ES469625A patent/ES469625A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES469625A1 (en) | 1978-12-16 |
| FR2378784B1 (en) | 1981-02-20 |
| SE7801001L (en) | 1978-07-28 |
| IE46501B1 (en) | 1983-06-29 |
| NO780294L (en) | 1978-07-28 |
| CH636878A5 (en) | 1983-06-30 |
| LU78948A1 (en) | 1979-04-09 |
| AU517925B2 (en) | 1981-09-03 |
| ES466365A1 (en) | 1978-10-01 |
| AU3276778A (en) | 1979-08-02 |
| FR2378784A1 (en) | 1978-08-25 |
| IT7847789A0 (en) | 1978-01-25 |
| AT358049B (en) | 1980-08-11 |
| IE780190L (en) | 1978-07-27 |
| BE863365A (en) | 1978-07-26 |
| NL7800993A (en) | 1978-07-31 |
| ATA27178A (en) | 1980-01-15 |
| ES469626A1 (en) | 1978-12-16 |
| GB1586532A (en) | 1981-03-18 |
| JPS5395998A (en) | 1978-08-22 |
| IT1102803B (en) | 1985-10-07 |
| DK39378A (en) | 1978-07-28 |
| FI780156A7 (en) | 1978-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |