ES469631A1 - Pyrole derivative process for preparing same and composition containing same - Google Patents
Pyrole derivative process for preparing same and composition containing sameInfo
- Publication number
- ES469631A1 ES469631A1 ES469631A ES469631A ES469631A1 ES 469631 A1 ES469631 A1 ES 469631A1 ES 469631 A ES469631 A ES 469631A ES 469631 A ES469631 A ES 469631A ES 469631 A1 ES469631 A1 ES 469631A1
- Authority
- ES
- Spain
- Prior art keywords
- same
- pyrole
- composition containing
- derivative process
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003233 pyrroles Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compounds of the formula < IMAGE > and derivatives thereof, in which R1 is hydrogen or methyl, Ar is a phenyl, a substituted phenyl or a thienyl, where the substituted phenyl is substituted by one or two groups selected from fluorine, chlorine, bromine, methyl, methoxy or trifluoromethyl, and X is a CO or CHOH group. The said pyrrole derivatives have an anti-inflammatory activity.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19465/77A GB1601107A (en) | 1977-05-10 | 1977-05-10 | Pyrrole derivatives |
| GB352978 | 1978-01-28 | ||
| GB575178 | 1978-02-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES469631A1 true ES469631A1 (en) | 1980-03-01 |
Family
ID=27254285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES469631A Expired ES469631A1 (en) | 1977-05-10 | 1978-05-09 | Pyrole derivative process for preparing same and composition containing same |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS53141268A (en) |
| AU (1) | AU526256B2 (en) |
| CA (1) | CA1100142A (en) |
| CH (1) | CH640225A5 (en) |
| DE (1) | DE2819463A1 (en) |
| DK (1) | DK204078A (en) |
| ES (1) | ES469631A1 (en) |
| FR (1) | FR2390431A1 (en) |
| IE (1) | IE46825B1 (en) |
| IL (1) | IL54642A (en) |
| NL (1) | NL7804942A (en) |
| SE (1) | SE7805282L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0032314A1 (en) * | 1980-01-09 | 1981-07-22 | Beecham Group Plc | Aroylpyrrole derivatives, processes for their preparation and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3752826A (en) * | 1970-01-26 | 1973-08-14 | Mcneilab Inc | Aroyl substituted pyrroles |
-
1978
- 1978-05-03 DE DE19782819463 patent/DE2819463A1/en not_active Withdrawn
- 1978-05-04 IL IL54642A patent/IL54642A/en unknown
- 1978-05-05 FR FR7813338A patent/FR2390431A1/en active Granted
- 1978-05-09 CA CA302,893A patent/CA1100142A/en not_active Expired
- 1978-05-09 SE SE7805282A patent/SE7805282L/en unknown
- 1978-05-09 DK DK204078A patent/DK204078A/en unknown
- 1978-05-09 IE IE942/78A patent/IE46825B1/en unknown
- 1978-05-09 NL NL7804942A patent/NL7804942A/en not_active Application Discontinuation
- 1978-05-09 ES ES469631A patent/ES469631A1/en not_active Expired
- 1978-05-09 CH CH503078A patent/CH640225A5/en not_active IP Right Cessation
- 1978-05-10 AU AU35990/78A patent/AU526256B2/en not_active Expired
- 1978-05-10 JP JP5539178A patent/JPS53141268A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1100142A (en) | 1981-04-28 |
| IE46825B1 (en) | 1983-10-05 |
| AU3599078A (en) | 1979-11-15 |
| FR2390431B1 (en) | 1981-11-06 |
| FR2390431A1 (en) | 1978-12-08 |
| DK204078A (en) | 1978-11-11 |
| AU526256B2 (en) | 1982-12-23 |
| IL54642A0 (en) | 1978-07-31 |
| IL54642A (en) | 1982-03-31 |
| IE780942L (en) | 1978-11-10 |
| JPS53141268A (en) | 1978-12-08 |
| NL7804942A (en) | 1978-11-14 |
| SE7805282L (en) | 1978-11-11 |
| CH640225A5 (en) | 1983-12-30 |
| DE2819463A1 (en) | 1978-11-16 |
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