ES470155A1 - Un procedimiento para la obtencion de derivados de espiroa- mina - Google Patents

Un procedimiento para la obtencion de derivados de espiroa- mina

Info

Publication number
ES470155A1
ES470155A1 ES470155A ES470155A ES470155A1 ES 470155 A1 ES470155 A1 ES 470155A1 ES 470155 A ES470155 A ES 470155A ES 470155 A ES470155 A ES 470155A ES 470155 A1 ES470155 A1 ES 470155A1
Authority
ES
Spain
Prior art keywords
spiroamine
derivatives
obtaining
procedure
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470155A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of ES470155A1 publication Critical patent/ES470155A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un procedimiento para la obtención de derivados de espiroamina de la fórmula: **(formula)** en la que R1 es un átomo de hidrógeno, un grupo alcohilo C1-C4, un grupo fenilo, o un grupo fenilo sustituido con un átomo de halógeno, un grupo alcohilo C1-C4 o un grupo alcoxi C1-C4, R2 es un átomo de hidrógeno, o bien R1 y R2, cuando se consideran juntos, pueden formar un grupo alcohileno C1-C4, W es un átomo de oxígeno o dos átomos de hidrogeno.
ES470155A 1978-02-13 1978-05-24 Un procedimiento para la obtencion de derivados de espiroa- mina Expired ES470155A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1577878A JPS54109983A (en) 1978-02-13 1978-02-13 Novel spiroamine derivative and its preparation

Publications (1)

Publication Number Publication Date
ES470155A1 true ES470155A1 (es) 1979-01-01

Family

ID=11898262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES470155A Expired ES470155A1 (es) 1978-02-13 1978-05-24 Un procedimiento para la obtencion de derivados de espiroa- mina

Country Status (13)

Country Link
US (1) US4233307A (es)
JP (1) JPS54109983A (es)
AT (1) AT356108B (es)
AU (1) AU511735B2 (es)
BE (1) BE867517A (es)
CA (1) CA1092106A (es)
CH (1) CH635841A5 (es)
DE (1) DE2822227A1 (es)
ES (1) ES470155A1 (es)
FR (1) FR2442845A1 (es)
IT (1) IT7849577A0 (es)
NL (1) NL7805814A (es)
SE (1) SE7805949L (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337260A (en) * 1981-09-10 1982-06-29 Yoshitomi Pharmaceutical Industries, Ltd. Imidazopyridine-spiro-piperidine compounds
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EP0702681A1 (en) * 1993-06-07 1996-03-27 Merck & Co. Inc. Spiro-substituted azacycles as neurokinin antagonists
CN1047386C (zh) * 1994-04-07 1999-12-15 西玛夫公司 新型褪黑激素拮抗物螺旋[吲哚吡咯烷丁]衍生物,其制备方法及其作为药物产品的用途
FR2724170B1 (fr) * 1994-09-02 1997-05-30 Cemaf Nouveaux derives de spiro(indole-pyrrolidine) agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
US5962462A (en) * 1996-12-13 1999-10-05 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013652A (en) * 1997-12-04 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin antagonists
JP2003505388A (ja) * 1999-07-21 2003-02-12 アストラゼネカ・アクチエボラーグ 新規化合物
GB0213715D0 (en) 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
AU2003268512A1 (en) * 2002-09-09 2004-03-29 Janssen Pharmaceutica N.V. Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
US7786141B2 (en) 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
US7879834B2 (en) 2004-08-19 2011-02-01 Vertex Pharmaceuticals Incorporated Spiroindoline modulators of muscarinic receptors
JP2008521825A (ja) * 2004-11-29 2008-06-26 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体のモジュレーター
EP2522669B1 (en) * 2005-06-02 2016-12-28 Janssen Pharmaceutica NV 3-Spirocyclic indolyl derivatives useful as ORL-1 receptor modulators
WO2007028638A1 (en) * 2005-09-09 2007-03-15 Euro-Celtique S.A. Fused and spirocycle compounds and the use thereof
CA2634456A1 (en) * 2005-12-22 2007-07-05 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
RU2008137583A (ru) * 2006-02-22 2010-03-27 Вертекс Фармасьютикалз Инкорпорейшн (Us) Спиропиперидины в качестве модуляторов мускариновых рецепторов
US8003660B2 (en) 2006-02-22 2011-08-23 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US7858790B2 (en) * 2006-06-29 2010-12-28 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CN101553231A (zh) * 2006-08-15 2009-10-07 弗特克斯药品有限公司 毒蕈碱受体调节剂
US7786107B2 (en) * 2006-08-18 2010-08-31 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CN103202840B (zh) * 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
EP2150552B1 (en) * 2007-04-09 2013-01-02 Janssen Pharmaceutica NV 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression
JP5224543B2 (ja) * 2007-05-18 2013-07-03 興和株式会社 新規なスピロオキシインドール化合物及びこれを含有する医薬
JP2010540640A (ja) 2007-10-03 2010-12-24 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン作用性レセプターのモジュレーター
MX2024008868A (es) * 2022-01-18 2024-09-23 Maze Therapeutics Inc Inhibidores de la apolipoproteína l1 (apol1) y métodos de uso.
EP4747251A1 (en) * 2023-07-17 2026-05-27 Maze Therapeutics, Inc. Apol1 inhibitors and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299075A (en) * 1964-03-12 1967-01-17 Smith Kline French Lab Spiro [3h-indole-3, 3'-pyrrolidine and piperidine] derivatives

Also Published As

Publication number Publication date
FR2442845A1 (fr) 1980-06-27
DE2822227A1 (de) 1979-08-16
US4233307A (en) 1980-11-11
AU511735B2 (en) 1980-09-04
AU3616978A (en) 1979-11-22
NL7805814A (nl) 1979-08-15
ATA388878A (de) 1979-09-15
SE7805949L (sv) 1979-08-14
IT7849577A0 (it) 1978-05-26
BE867517A (fr) 1978-09-18
FR2442845B1 (es) 1981-07-24
JPS54109983A (en) 1979-08-29
AT356108B (de) 1980-04-10
CA1092106A (en) 1980-12-23
CH635841A5 (de) 1983-04-29

Similar Documents

Publication Publication Date Title
ES455149A1 (es) Procedimiento para preparar n-fenil-n'-benzoil-ureas.
ES455294A1 (es) Un procedimiento de preparacion de una fenilamidina sustituida.
ES2055368T3 (es) Procedimiento para la preparacion enantioselectiva de derivados de la fenilisoserina.
ES467183A1 (es) Procedimiento para la preparacion de homopoliester o copo- liesteres lineales.
ES470781A1 (es) Procedimiento para la preparacion de nuevas 4-acilamino-fe- nil-etanolaminas
ES470743A1 (es) Un procedimiento para preparar derivados de 4-halo-dihidro- pirano
ES462422A1 (es) Procedimiento para la preparacion de compuestos derivados den-alquil-sulfo-noxi-acetil-anilinas.
ES481917A1 (es) Procedimiento para la preparacion de nuevos acidos tiazol-2-oxamicos sustituidos en posicion 4.
ES481633A1 (es) Un procedimiento de preparacion de derivados de 4-fenil-2- tiazolil-oxamato.
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
ES471254A1 (es) Procedimiento para la preparacion de nuevas imidazo-isoqui- nolein-dionas
ES462890A1 (es) Procedimiento para la preparacion de 1-(n-acil-carbamoil)-2-cianazi-ridinas con efecto cancerostatico y estimulador de inmunidad.
DK392579A (da) Fremgangsmaade til fremstilling af 4,5-methano-bufadienolid-rhamnosider
ES451466A1 (es) Procedimiento para la preparacion de nuevos derivados de 5- tiazol-metanoamina.
ES468360A1 (es) Procedimiento para la preparacion de 2-(2',2',2'-trihalogenetil)-4-halogenciclobutan-1-ona.
ES8304086A1 (es) "un procedimiento para preparar derivados heterociclicos de amidoximas".
DK82583D0 (da) Furyloxazolyleddikesyrederivater og fremgangsmader til fremstilling deraf
ES462599A1 (es) Procedimiento para la preparacion de derivados de acidos- 2-(fenil-alcohilhidrazono)-propionico.
ES451741A2 (es) Procedimiento para preparar derivados de naftiridina.
IE44449L (en) Morphanthridines
ES419019A1 (es) Procedimiento para la preparacion de compuestos polici- clicos.
ES550218A0 (es) Procedimiento para la obtencion de dihidrotiazinas asimetri-cas
ES453829A1 (es) Procedimiento de preparacion de quinazolinonas
ES457895A1 (es) Metodo para preparar derivados de tirosina.
ES463284A2 (es) Procedimiento para preparar 1-(3,3,3-triarilpropil)-4-fenil-4-piperidina-metanoles.