ES470428A1 - Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina - Google Patents

Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina

Info

Publication number
ES470428A1
ES470428A1 ES470428A ES470428A ES470428A1 ES 470428 A1 ES470428 A1 ES 470428A1 ES 470428 A ES470428 A ES 470428A ES 470428 A ES470428 A ES 470428A ES 470428 A1 ES470428 A1 ES 470428A1
Authority
ES
Spain
Prior art keywords
formula
heterocyclic compound
compounds
symbols
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470428A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES470428A1 publication Critical patent/ES470428A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • C07D233/78—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un método de preparación de compuestos heterocíclicos derivados de hidantoína de formula (I) **(formula)** en la que Z es hidrógeno o alcohilo; uno de Z1 y Z2 está representado por el grupo -CH-X-X1-X2x; en el que X es fenileno, -C=C-, -CH=CH- cis ó trans, ó -CH2-CQ2- donde cada Q se selecciona independientemente de entre hidrógeno y alcohilo o bien los dos grupos Q forman juntos un radical alcohileno que tiene cuatro, cinco o seis átomos de carbono; X1 es un enlace covalente o una cadena de alcohileno recta o ramificada que tiene 1 a 6 átomos de carbono y que tiene opcionalmente uno de sus grupos metileno reemplazado por oxa (-0-) con la condición de que al menos un átomo de carbono separa el grupo oxa de un grupo-C=-, -CH=CH- ó -CO; y X2 se selecciona de entre 5-tetrazolilo, carboxilo, carboxamido, hidroximetileno y alcoxicarbonilo.
ES470428A 1976-06-03 1978-06-01 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina Expired ES470428A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2287776 1976-06-03
GB5034076 1976-12-02
GB1214577 1977-03-23

Publications (1)

Publication Number Publication Date
ES470428A1 true ES470428A1 (es) 1979-09-01

Family

ID=27256793

Family Applications (5)

Application Number Title Priority Date Filing Date
ES459412A Expired ES459412A1 (es) 1976-06-03 1977-06-02 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina.
ES470428A Expired ES470428A1 (es) 1976-06-03 1978-06-01 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina
ES478156A Expired ES478156A1 (es) 1976-06-03 1979-02-28 Un metodo de preparacion de compuestos heterociclicos derivados de hidantoina.
ES482010A Expired ES482010A1 (es) 1976-06-03 1979-06-28 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina.
ES489883A Expired ES8103057A1 (es) 1976-06-03 1980-03-25 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES459412A Expired ES459412A1 (es) 1976-06-03 1977-06-02 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES478156A Expired ES478156A1 (es) 1976-06-03 1979-02-28 Un metodo de preparacion de compuestos heterociclicos derivados de hidantoina.
ES482010A Expired ES482010A1 (es) 1976-06-03 1979-06-28 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina.
ES489883A Expired ES8103057A1 (es) 1976-06-03 1980-03-25 Un metodo de preparacion de compuestos heterociclicos deri- vados de hidantoina

Country Status (12)

Country Link
JP (1) JPS52151168A (es)
CA (1) CA1176261A (es)
CH (3) CH645631A5 (es)
DE (1) DE2724948A1 (es)
DK (1) DK244577A (es)
ES (5) ES459412A1 (es)
FI (1) FI71930C (es)
FR (1) FR2362839A1 (es)
HU (1) HU183046B (es)
NL (1) NL7706064A (es)
NZ (1) NZ184281A (es)
SE (2) SE446336B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602188A (en) * 1977-12-01 1981-11-11 Wellcome Found Hydantoin derivatives
IE48747B1 (en) * 1977-09-05 1985-05-15 Wellcome Found Hydantoin derivatives
DK543178A (da) * 1977-12-01 1979-06-02 Wellcome Found Thiodydantoinderivater
DE2963795D1 (en) * 1978-01-23 1982-11-11 Beecham Group Plc Hydantoins and thiohydantoins, method for their preparation and pharmaceutical compositions containing them
EP0004723A1 (en) * 1978-03-30 1979-10-17 Beecham Group Plc Deoxyhydantoins, processes for their preparation and pharmaceutical compositions containing them
GB1599740A (en) * 1978-05-31 1981-10-07 Wellcome Found Hydantoin derivatives
US4294972A (en) * 1978-06-15 1981-10-13 Beecham Group Limited 1,2-Disubstituted oxo triazolidine
AU4778279A (en) * 1978-06-15 1979-12-20 Beecham Group Limited Prostaglandin analogues
EP0006352A1 (en) * 1978-06-15 1980-01-09 Beecham Group Plc Hydantoins and thiohydantoins, process for their preparation and pharmaceutical compositions containing them
IL57504A0 (en) * 1978-06-15 1979-10-31 Beecham Group Ltd Prostagandin analogues,their preparation and pharmaceutical compositions containing
IL59065A0 (en) * 1979-01-18 1980-05-30 Beecham Group Ltd Hydantoin derivatives,their preparation pharmaceutical compositons containing them
EP0019223A1 (en) * 1979-05-09 1980-11-26 The Wellcome Foundation Limited Optically active hydantoin derivatives, their synthesis, pharmaceutical formulations containing them, and intermediates
US4684735A (en) * 1985-07-01 1987-08-04 Stauffer Chemical Company Promotion of raney nickel hydrogenation catalyst
JP3022878U (ja) * 1995-08-18 1996-04-02 有限会社春江加工 ミニディスク用ケース
US7544812B2 (en) * 2001-11-30 2009-06-09 Eli Lilly And Company Peroxisome proliferator activated receptor agonists
BRPI0411057A (pt) * 2003-06-06 2006-07-25 Allergan Inc análogos de prostaglandina e de piperidinila
US7179820B2 (en) * 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1524818A (en) * 1974-11-29 1978-09-13 Beecham Group Ltd 12-azaprostaglandins

Also Published As

Publication number Publication date
NL7706064A (nl) 1977-12-06
FI71930C (fi) 1987-03-09
SE446336B (sv) 1986-09-01
CH645631A5 (en) 1984-10-15
FR2362839A1 (fr) 1978-03-24
SE7706428L (sv) 1977-12-04
FI71930B (fi) 1986-11-28
DK244577A (da) 1977-12-04
HU183046B (en) 1984-04-28
FI771763A7 (fi) 1977-12-04
FR2362839B1 (es) 1980-02-01
JPS6222986B2 (es) 1987-05-20
ES489883A0 (es) 1981-02-16
CH647511A5 (en) 1985-01-31
JPS52151168A (en) 1977-12-15
CA1176261A (en) 1984-10-16
ES8103057A1 (es) 1981-02-16
CH646426A5 (en) 1984-11-30
ES478156A1 (es) 1979-11-01
DE2724948A1 (de) 1977-12-15
ES459412A1 (es) 1978-11-01
ES482010A1 (es) 1980-08-16
NZ184281A (en) 1980-04-28
SE8203161L (sv) 1982-05-19

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401