ES473371A1 - Un procedimiento para preparar cefamandol cristalino puro - Google Patents
Un procedimiento para preparar cefamandol cristalino puroInfo
- Publication number
- ES473371A1 ES473371A1 ES473371A ES473371A ES473371A1 ES 473371 A1 ES473371 A1 ES 473371A1 ES 473371 A ES473371 A ES 473371A ES 473371 A ES473371 A ES 473371A ES 473371 A1 ES473371 A1 ES 473371A1
- Authority
- ES
- Spain
- Prior art keywords
- cefamandole
- alkali metal
- ammonium salts
- preparing pure
- crystalline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OLVCFLKTBJRLHI-AXAPSJFSSA-N cefamandole Chemical compound CN1N=NN=C1SCC1=C(C(O)=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OLVCFLKTBJRLHI-AXAPSJFSSA-N 0.000 title abstract 3
- 229960003012 cefamandole Drugs 0.000 title abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 title abstract 2
- 150000001340 alkali metals Chemical class 0.000 title abstract 2
- 150000003863 ammonium salts Chemical class 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000005411 Van der Waals force Methods 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- OJMNTWPPFNMOCJ-CFOLLTDRSA-M cefamandole sodium Chemical compound [Na+].CN1N=NN=C1SCC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)[C@H](O)C=3C=CC=CC=3)[C@H]2SC1 OJMNTWPPFNMOCJ-CFOLLTDRSA-M 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000020477 pH reduction Effects 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Un procedimiento para preparar cefamandol cristalino puro a partir de las sales de amonio y de metal alcalino del mismo, que comprende las siguientes etapas (a) disolver una sal de amonio de metal alcalino de cefamandol en agua, (b) acidular la solución de a(a) con una solución tampón a un pH de aproximadamente 3,5 a 4,5 © hacer pasar la solución de (b) a través de un lecho de resina adsorbente que tiene una superficie activa grande (macroporosidad) que conduce a una adsorción de van der Waals, y que tiene una actividad de electrolito débil, habiéndose acondicionado previamente dicha resina con una solución tampón que tiene un pH de aproximadamente 3,5 a 4,5 (d) ajustar el pH de dicho efluente a aproximadamente 2,0 con un ácido no oxidate y (e) separar el cefamandol cristalino del efluente acidulado de (d)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/834,633 US4115644A (en) | 1977-09-19 | 1977-09-19 | Process for preparing pure cefamandole from alkali metal and ammonium salts thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES473371A1 true ES473371A1 (es) | 1979-11-01 |
Family
ID=25267406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES473371A Expired ES473371A1 (es) | 1977-09-19 | 1978-09-14 | Un procedimiento para preparar cefamandol cristalino puro |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4115644A (es) |
| JP (1) | JPS5455594A (es) |
| CA (1) | CA1100945A (es) |
| DE (1) | DE2839670A1 (es) |
| ES (1) | ES473371A1 (es) |
| FR (1) | FR2403345A1 (es) |
| GB (1) | GB2004280B (es) |
| IE (1) | IE47441B1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101787039B (zh) * | 2010-01-26 | 2012-05-09 | 陶灵刚 | 一种高纯度的头孢美唑钠化合物 |
| CN102093392B (zh) * | 2011-01-28 | 2013-04-24 | 海南灵康制药有限公司 | 一种头孢孟多酯钠的新制法 |
| CN103044453B (zh) * | 2013-01-22 | 2014-07-30 | 湖北济生医药有限公司 | 头孢孟多酯钠化合物及其药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
| US3840531A (en) * | 1972-03-21 | 1974-10-08 | Lilly Co Eli | Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof |
| BE824028A (fr) * | 1974-01-23 | 1975-06-30 | Procede pour la purification de cephalosporines comportant un groupe acide carboxylique libre | |
| US4028355A (en) * | 1974-01-23 | 1977-06-07 | Smithkline Corporation | Cephalosporin purification process |
| US3947415A (en) * | 1974-12-23 | 1976-03-30 | Eli Lilly And Company | Cefamandole derivatives |
| US4029655A (en) * | 1975-04-11 | 1977-06-14 | Eli Lilly And Company | Method of preparing stable sterile crystalline cephalosporins for parenteral administration |
-
1977
- 1977-09-19 US US05/834,633 patent/US4115644A/en not_active Expired - Lifetime
-
1978
- 1978-09-12 DE DE19782839670 patent/DE2839670A1/de not_active Withdrawn
- 1978-09-12 CA CA311,083A patent/CA1100945A/en not_active Expired
- 1978-09-12 FR FR7826145A patent/FR2403345A1/fr active Granted
- 1978-09-14 ES ES473371A patent/ES473371A1/es not_active Expired
- 1978-09-14 GB GB7836885A patent/GB2004280B/en not_active Expired
- 1978-09-18 IE IE1876/78A patent/IE47441B1/en unknown
- 1978-09-18 JP JP11506378A patent/JPS5455594A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| IE781876L (en) | 1979-03-19 |
| US4115644A (en) | 1978-09-19 |
| FR2403345B1 (es) | 1982-09-10 |
| DE2839670A1 (de) | 1979-03-29 |
| GB2004280B (en) | 1982-03-10 |
| GB2004280A (en) | 1979-03-28 |
| CA1100945A (en) | 1981-05-12 |
| FR2403345A1 (fr) | 1979-04-13 |
| JPS5455594A (en) | 1979-05-02 |
| IE47441B1 (en) | 1984-03-21 |
| JPS6312873B2 (es) | 1988-03-23 |
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