ES473701A1 - Procedimiento de preparacion del 2-cetoglutarato de vincami-na - Google Patents
Procedimiento de preparacion del 2-cetoglutarato de vincami-naInfo
- Publication number
- ES473701A1 ES473701A1 ES473701A ES473701A ES473701A1 ES 473701 A1 ES473701 A1 ES 473701A1 ES 473701 A ES473701 A ES 473701A ES 473701 A ES473701 A ES 473701A ES 473701 A1 ES473701 A1 ES 473701A1
- Authority
- ES
- Spain
- Prior art keywords
- vincamine
- translation
- machine
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract 8
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002726 vincamine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- RXPRRQLKFXBCSJ-HLAWJBBLSA-N 16-epivincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-HLAWJBBLSA-N 0.000 abstract 1
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 abstract 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N N-alpha-Methylhistamine Chemical compound CNCCC1=CN=CN1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
- -1 aluminum lithium hydride Chemical compound 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- NDKBVBUGCNGSJJ-UHFFFAOYSA-M benzyltrimethylammonium hydroxide Chemical compound [OH-].C[N+](C)(C)CC1=CC=CC=C1 NDKBVBUGCNGSJJ-UHFFFAOYSA-M 0.000 abstract 1
- 230000026030 halogenation Effects 0.000 abstract 1
- 238000005658 halogenation reaction Methods 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000741 silica gel Substances 0.000 abstract 1
- 229910002027 silica gel Inorganic materials 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Procedimiento de prerparación del 2-cetoglutarato de vincamina, según reivindicaciones anteriores, caracterizado porque la 12-bencil-1-carbometoxi-1-etil-1,2,3,4,6,7,12,12b- octahidro-indolo-(2,3-a) quinolicina se somete, sucesivamente, a reducción con aluminiohidruro de litio, halogenación con tribromuro de fósforo, acción del anión carbonilequivalente del dietilmercapto acetato de metilo, sucesiva hidrólisis e hidrogenolisis, dando una mezcla de vincamina y epivincamina y, esta mezcla tratada con hidróxido de benciltrimetilamonio, es cromatografiada sobre gel de sílice, dando vincamina como producto único.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES473701A ES473701A1 (es) | 1978-09-27 | 1978-09-27 | Procedimiento de preparacion del 2-cetoglutarato de vincami-na |
| AR274859A AR220164A1 (es) | 1978-09-27 | 1978-12-18 | Procedimiento de preparacion de vincamina y 16-epivincamina |
| BR7906216A BR7906216A (pt) | 1978-09-27 | 1979-09-27 | Processo para preparacao de 2-cetoglutarato de vincamina |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES473701A ES473701A1 (es) | 1978-09-27 | 1978-09-27 | Procedimiento de preparacion del 2-cetoglutarato de vincami-na |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES473701A1 true ES473701A1 (es) | 1979-04-01 |
Family
ID=8476821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES473701A Expired ES473701A1 (es) | 1978-09-27 | 1978-09-27 | Procedimiento de preparacion del 2-cetoglutarato de vincami-na |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR220164A1 (es) |
| BR (1) | BR7906216A (es) |
| ES (1) | ES473701A1 (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316029A (en) | 1979-06-22 | 1982-02-16 | Synthelabo | Synthesis of vincaminic acid derivatives |
-
1978
- 1978-09-27 ES ES473701A patent/ES473701A1/es not_active Expired
- 1978-12-18 AR AR274859A patent/AR220164A1/es active
-
1979
- 1979-09-27 BR BR7906216A patent/BR7906216A/pt unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316029A (en) | 1979-06-22 | 1982-02-16 | Synthelabo | Synthesis of vincaminic acid derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| BR7906216A (pt) | 1980-05-27 |
| AR220164A1 (es) | 1980-10-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990222 |