ES475100A1 - Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos - Google Patents

Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos

Info

Publication number
ES475100A1
ES475100A1 ES475100A ES475100A ES475100A1 ES 475100 A1 ES475100 A1 ES 475100A1 ES 475100 A ES475100 A ES 475100A ES 475100 A ES475100 A ES 475100A ES 475100 A1 ES475100 A1 ES 475100A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
benzisoxazolyloxy
thio
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475100A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES475100A1 publication Critical patent/ES475100A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Nuevos ácidos 1,2-benzisoxazoloxiacéticos y compuestos relacionados que son útiles como diuréticos, uricosúricos e hipertensores a métodos para su preparación y a composiciones a métodos para su preparación y a composiciones farmacéuticas que contienen tales compuestos como ingrediente activo.
ES475100A 1977-11-21 1978-11-15 Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos Expired ES475100A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85331377A 1977-11-21 1977-11-21
US94912878A 1978-10-06 1978-10-06

Publications (1)

Publication Number Publication Date
ES475100A1 true ES475100A1 (es) 1979-12-01

Family

ID=27127134

Family Applications (3)

Application Number Title Priority Date Filing Date
ES475100A Expired ES475100A1 (es) 1977-11-21 1978-11-15 Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos
ES482056A Expired ES482056A1 (es) 1977-11-21 1979-06-29 Un metodo par preparar acidos 1,2-benzisocazoloxiaceticos.
ES482055A Expired ES482055A1 (es) 1977-11-21 1979-06-29 Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES482056A Expired ES482056A1 (es) 1977-11-21 1979-06-29 Un metodo par preparar acidos 1,2-benzisocazoloxiaceticos.
ES482055A Expired ES482055A1 (es) 1977-11-21 1979-06-29 Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos.

Country Status (18)

Country Link
EP (1) EP0002666B1 (es)
JP (1) JPS5495563A (es)
AT (1) AT371811B (es)
AU (1) AU521533B2 (es)
CA (1) CA1111853A (es)
DE (1) DE2861637D1 (es)
DK (1) DK515978A (es)
EG (1) EG13533A (es)
ES (3) ES475100A1 (es)
FI (1) FI783515A7 (es)
GR (1) GR72950B (es)
HU (1) HU180785B (es)
IE (1) IE47299B1 (es)
IL (1) IL55997A0 (es)
IT (1) IT7829897A0 (es)
NO (1) NO783908L (es)
NZ (1) NZ188946A (es)
PT (1) PT68807A (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337261A (en) * 1980-07-28 1982-06-29 Hoechst-Roussel Pharmaceuticals Inc. (1,2-Benzisoxazol)phenoxyacetic acids as diuretics
US4504669A (en) * 1981-02-25 1985-03-12 Hoechst-Roussel Pharmaceuticals Inc. 1,2-Benzisoxazoloxyethylamines and intermediates for the preparation thereof
US4644064A (en) * 1981-02-25 1987-02-17 Hoechst-Roussel Pharmaceuticals Inc. 1,2-benzisoxazoloxyethylamines and intermediates for the preparation thereof
US4427691A (en) * 1981-02-25 1984-01-24 Hoechst-Roussel Pharmaceuticals Inc. 1,2-Benzisoxazoloxyethylamines and intermediates for the preparation thereof
US4452804A (en) * 1981-02-25 1984-06-05 Hoechst-Roussel Pharmaceuticals Inc. 1,2-Benzisoxazoloxyethylamines and intermediates for the preparation thereof
JPS59128347A (ja) * 1983-01-12 1984-07-24 Daikin Ind Ltd 含フツ素ベンゾフエノン誘導体
US4458076A (en) * 1983-05-31 1984-07-03 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidinyl)-1,2-benzisothiazoles
GB9620202D0 (en) * 1996-09-27 1996-11-13 Rhone Poulenc Agriculture New herbicides
TW200637839A (en) 2005-01-07 2006-11-01 Taisho Pharmaceutical Co Ltd 1-thio-d-glucitol derivatives
WO2008035359A2 (en) * 2006-06-12 2008-03-27 Cadila Healthcare Limited Oximinophenoxyalkanoic acid and phenylalkanoic acid derivatives
AR081930A1 (es) * 2010-06-16 2012-10-31 Ardea Biosciences Inc Compuestos de tioacetato

Also Published As

Publication number Publication date
IT7829897A0 (it) 1978-11-17
IE47299B1 (en) 1984-02-08
EG13533A (en) 1981-12-31
IE782275L (en) 1979-05-21
DK515978A (da) 1979-05-22
AU4171678A (en) 1979-05-31
HU180785B (en) 1983-04-29
NO783908L (no) 1979-05-22
DE2861637D1 (en) 1982-03-25
AU521533B2 (en) 1982-04-08
ES482056A1 (es) 1980-09-01
FI783515A7 (fi) 1979-05-22
JPS5495563A (en) 1979-07-28
ES482055A1 (es) 1980-09-01
CA1111853A (en) 1981-11-03
AT371811B (de) 1983-08-10
NZ188946A (en) 1983-05-10
EP0002666B1 (de) 1982-02-17
ATA824478A (de) 1982-12-15
EP0002666A1 (de) 1979-07-11
PT68807A (en) 1978-12-01
GR72950B (es) 1984-01-17
IL55997A0 (en) 1979-01-31

Similar Documents

Publication Publication Date Title
JPS57122049A (en) 1,1,2-triphenylbutene-1 derivative and therapeutically soluble salt, manufacture and medicine
GB2008109B (en) Salscted process for producing monohalogenated derivatives of 7-hydroxy-coumarin
AU501974B2 (en) Organophosporos derivatives of benztriazole
ES482055A1 (es) Un metodo para preparar acidos 1,2-benzisoxazoloxiaceticos.
IL55236A (en) Prostaglandin i2 derivatives,process for their production and pharmaceutical compositions containing them
HU172710B (hu) Sposob poluchenija proizvodnykh 4,4'-oksi-bis/2-fenoksi-alkalkarbonovykh kislot/
DE2861043D1 (en) Cephalosporin derivatives, process for their preparation and pharmaceutical compositions and their preparation
ZA766745B (en) 3,4-dihydro-quinazoline derivatives and process for their preparation
AU504589B2 (en) N-oxides of 9, 10-dehydro-9, 10-methanoanthracene "aminoalkyl derivatives
AU524143B2 (en) Aminoalkyl furan derivatives
JPS5210292A (en) Production of functional adenine derivative and use of same for producing high molecular derivative
ZA781020B (en) New 20,21-dinoreburnamenine derivatives,process for preparing them and pharmaceutical compositions
CS194774B2 (en) Process for preparing derivatives of 1,4-dihydropyridine suitable especially as antihypertensive and antianginar medicament
JPS5430183A (en) 3,4-dihydrocarbostyril derivative
AU509855B2 (en) Compositions of 1, 2, 4-rhiadiazine derivatives
JPS5419969A (en) Proline derivative and its preparation
GR61615B (en) Preparation process of thiadiazolyl derivatives of 7-acylamido-3-cephem-4-carboxylic acid
ES479234A1 (es) Procedimiento para la obtencion de derivados de antraquinona.
IL54070A0 (en) 17 -acetylene derivatives of androst-4-ene, process for preparing them and pharmaceutical compositions
AU514033B2 (en) New 20, 21-dinoreburnamenine derivatives, process for preparing them and pharmaceutical compositions
AU483111B2 (en) New-n-(2-pyrrolidinyl alkyl) substituted benzamides, their derivatives and its process of preparation
FR2407931A1 (fr) Derives de l'eburnamenine et leur application en therapeutique
AU492639B2 (en) Novel aryloxyaminobutanol derivatives anda process forthe preparation thereof
IL55688A (en) 1,4-dihydropyridazine-5-carboxylic acid derivatives,their production and pharmaceutical compositions containing them
ES461257A1 (es) Un procedimiento para la preparacion de derivados de 1,4-di-hidropiridina.