ES476251A1 - Procedimiento de fabricacion de nuevos derivados de la benzamida. - Google Patents
Procedimiento de fabricacion de nuevos derivados de la benzamida.Info
- Publication number
- ES476251A1 ES476251A1 ES476251A ES476251A ES476251A1 ES 476251 A1 ES476251 A1 ES 476251A1 ES 476251 A ES476251 A ES 476251A ES 476251 A ES476251 A ES 476251A ES 476251 A1 ES476251 A1 ES 476251A1
- Authority
- ES
- Spain
- Prior art keywords
- benzamide
- derivates
- new
- lower alkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 102000015427 Angiotensins Human genes 0.000 abstract 1
- 108010064733 Angiotensins Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102100028255 Renin Human genes 0.000 abstract 1
- 108090000783 Renin Proteins 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 229940030606 diuretics Drugs 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 159000000001 potassium salts Chemical class 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- -1 sulphamoyl Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedimiento de fabricación de nuevos derivados de la benzamida, terapéuticamente activos, de fórmula general **fórmula** en la cual R1 y R2 son, independientemente el uno del otro hidrógeno o un grupo alquilo inferior. R3 es un grupo fenilo o alquilo inferior o alquenilo inferior. R4 es un halógeno o un grupo trifluorometilo o nitro. R5 es un grupo sulfamoilo o carboxilo o carboxalquilo caracterizado porque se hace reaccionar un compuesto de la fórmula con un aldeído de fórmula R3-CHO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH47278A CH627446A5 (fr) | 1978-01-17 | 1978-01-17 | Nouveaux derives de la benzamide. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES476251A1 true ES476251A1 (es) | 1979-04-16 |
Family
ID=4187781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES476251A Expired ES476251A1 (es) | 1978-01-17 | 1978-12-21 | Procedimiento de fabricacion de nuevos derivados de la benzamida. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4312862A (es) |
| EP (1) | EP0009487B1 (es) |
| AR (1) | AR220367A1 (es) |
| AT (1) | AT363458B (es) |
| AU (1) | AU522497B2 (es) |
| BE (1) | BE873392A (es) |
| CA (1) | CA1142545A (es) |
| CH (1) | CH627446A5 (es) |
| DE (1) | DE2966947D1 (es) |
| ES (1) | ES476251A1 (es) |
| NL (1) | NL7812599A (es) |
| PT (1) | PT69081A (es) |
| WO (1) | WO1979000517A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR855574A (fr) | 1938-06-02 | 1940-05-15 | Burkhardt & Weber K G L | Porte-outil pour machines-outils à avance forcée |
| BE599310A (fr) * | 1960-01-22 | 1961-07-20 | Ciba Geigy | 4-oxo-1,2,3,4,-tétrahydro-quinazolines et procédé de leur préparation |
| FR1011M (fr) * | 1961-03-14 | 1961-12-18 | Eprova Ag | Nouvelles bases de schiff dérivées des sulfanilamides. |
| DE1232159B (de) * | 1962-11-30 | 1967-01-12 | Bayer Ag | Verfahren zur Herstellung von trifluormethylgruppenhaltigen beta-Aminosaeureaniliden |
| FR1403935A (fr) * | 1963-06-05 | 1965-06-25 | Ciba Geigy | Nouveaux amides d'acides anthraniliques |
-
1978
- 1978-01-17 CH CH47278A patent/CH627446A5/fr not_active IP Right Cessation
- 1978-12-21 ES ES476251A patent/ES476251A1/es not_active Expired
- 1978-12-28 NL NL7812599A patent/NL7812599A/xx not_active Application Discontinuation
-
1979
- 1979-01-05 CA CA000319176A patent/CA1142545A/en not_active Expired
- 1979-01-08 AU AU43191/79A patent/AU522497B2/en not_active Ceased
- 1979-01-09 AR AR275112A patent/AR220367A1/es active
- 1979-01-10 EP EP79900115A patent/EP0009487B1/fr not_active Expired
- 1979-01-10 DE DE7979900115T patent/DE2966947D1/de not_active Expired
- 1979-01-10 BE BE192830A patent/BE873392A/xx not_active IP Right Cessation
- 1979-01-10 WO PCT/CH1979/000003 patent/WO1979000517A1/de not_active Ceased
- 1979-01-16 PT PT7969081A patent/PT69081A/pt unknown
- 1979-01-17 AT AT0034379A patent/AT363458B/de not_active IP Right Cessation
- 1979-07-19 US US06/142,058 patent/US4312862A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| BE873392A (fr) | 1979-05-02 |
| AT363458B (de) | 1981-08-10 |
| AU4319179A (en) | 1979-07-26 |
| EP0009487B1 (fr) | 1984-05-02 |
| PT69081A (fr) | 1979-02-01 |
| DE2966947D1 (en) | 1984-06-07 |
| US4312862A (en) | 1982-01-26 |
| AU522497B2 (en) | 1982-06-10 |
| CH627446A5 (fr) | 1982-01-15 |
| NL7812599A (nl) | 1979-07-19 |
| EP0009487A1 (fr) | 1980-04-16 |
| WO1979000517A1 (fr) | 1979-08-09 |
| ATA34379A (de) | 1981-01-15 |
| CA1142545A (en) | 1983-03-08 |
| AR220367A1 (es) | 1980-10-31 |
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