ES476568A1 - Procedimiento para preparar una composicion farmaceutica re-vestida, soluble en el duodeno. - Google Patents

Procedimiento para preparar una composicion farmaceutica re-vestida, soluble en el duodeno.

Info

Publication number
ES476568A1
ES476568A1 ES79476568A ES476568A ES476568A1 ES 476568 A1 ES476568 A1 ES 476568A1 ES 79476568 A ES79476568 A ES 79476568A ES 476568 A ES476568 A ES 476568A ES 476568 A1 ES476568 A1 ES 476568A1
Authority
ES
Spain
Prior art keywords
chlorodibenzo
oxepin
methylpiperazine
coated
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES79476568A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES476568A1 publication Critical patent/ES476568A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para preparar una composición farmacéutica, revestida , soluble en el duodeno, adecuada para ingestión oral, caracterizada porque comprende preparar un núcleo que tiene de 6 a 33% por peso de 1-(2-clorodibenzo[b,f]oxepin-10-il)-4-metilpiperazina o una sal farmaceúticamente aceptable de la misma, y de 67 a 94% por peso de un portador farmacéutico inerte; revestir este núcleo con una solución de disolvente orgánico de ftalato de hidroxipropil metilcelulosa; remover el disolvente orgánico y aplicar revestimientos sucesivos hasta que la composición contenga de 7 a 15% por peso del ftalato de hidroxipropil metilcelulosa y tenga un espesor de revestimiento de 0.1 a 0.2 milímetros.
ES79476568A 1978-01-05 1979-01-04 Procedimiento para preparar una composicion farmaceutica re-vestida, soluble en el duodeno. Expired ES476568A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86716778A 1978-01-05 1978-01-05
US05/964,008 US4180559A (en) 1978-01-05 1978-12-01 Coated 1-(2-chlorodibenzo[b,f]oxepin-10-yl)-4-methylpiperazine compositions

Publications (1)

Publication Number Publication Date
ES476568A1 true ES476568A1 (es) 1979-12-16

Family

ID=27127997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES79476568A Expired ES476568A1 (es) 1978-01-05 1979-01-04 Procedimiento para preparar una composicion farmaceutica re-vestida, soluble en el duodeno.

Country Status (12)

Country Link
US (1) US4180559A (es)
JP (1) JPS54101418A (es)
AU (1) AU518748B2 (es)
CA (1) CA1107198A (es)
DE (1) DE2856865A1 (es)
ES (1) ES476568A1 (es)
FR (1) FR2413909A1 (es)
GB (1) GB2011785B (es)
IL (1) IL56253A0 (es)
IT (1) IT1162254B (es)
NL (1) NL7900080A (es)
PH (1) PH15206A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1146866A (en) * 1979-07-05 1983-05-24 Yamanouchi Pharmaceutical Co. Ltd. Process for the production of sustained release pharmaceutical composition of solid medical material
JPS6051124A (ja) * 1983-08-31 1985-03-22 Kohjin Co Ltd 腸溶性材コ−ティング液
GB8414220D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Medicaments in unit dose form
US5188840A (en) * 1985-09-26 1993-02-23 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
US5460825A (en) * 1990-05-23 1995-10-24 Mcneil-Ppc, Inc. Taste mask coatings for preparing chewable pharmaceutical tablets
US5260072A (en) * 1990-08-30 1993-11-09 Mcneil-Ppc, Inc. Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets
WO1995002339A1 (en) * 1993-07-14 1995-01-26 Opta Food Ingredients, Inc. Shellac dispersions and coatings, and method of making
MX219629B (es) * 1997-04-25 2004-03-30 Sembiosys Genetics Inc Metodo para separar proteinas de fusion
CN1440278A (zh) * 2000-06-02 2003-09-03 希龙公司 2′－脱氧－2′－(氟亚甲基)胞嘧啶核苷的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL137032C (es) * 1967-03-28 Richardson Merrell Spa
JPS50129727A (es) * 1974-04-04 1975-10-14
JPS517116A (en) * 1974-06-11 1976-01-21 Shinetsu Chemical Co Choyoseihifukuyakuzaino seizohoho

Also Published As

Publication number Publication date
IL56253A0 (en) 1979-03-12
DE2856865A1 (de) 1979-07-12
IT7947533A0 (it) 1979-01-04
FR2413909A1 (fr) 1979-08-03
GB2011785A (en) 1979-07-18
JPS54101418A (en) 1979-08-10
AU518748B2 (en) 1981-10-15
AU4272878A (en) 1979-07-12
US4180559A (en) 1979-12-25
NL7900080A (nl) 1979-07-09
CA1107198A (en) 1981-08-18
PH15206A (en) 1982-09-27
GB2011785B (en) 1982-05-19
IT1162254B (it) 1987-03-25

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