ES477086A1 - Procedimiento para la preparacion de 4-metil-5-hidroximetil-imidazol. - Google Patents

Procedimiento para la preparacion de 4-metil-5-hidroximetil-imidazol.

Info

Publication number
ES477086A1
ES477086A1 ES477086A ES477086A ES477086A1 ES 477086 A1 ES477086 A1 ES 477086A1 ES 477086 A ES477086 A ES 477086A ES 477086 A ES477086 A ES 477086A ES 477086 A1 ES477086 A1 ES 477086A1
Authority
ES
Spain
Prior art keywords
methyl
imidazole
procedure
preparation
hydroximethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES477086A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Eprova AG
Original Assignee
Eprova AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eprova AG filed Critical Eprova AG
Publication of ES477086A1 publication Critical patent/ES477086A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de 4-metil-5-hidroximetil-imidazol, por reacción de 4-metil-imidazol con formaldehido, caracterizado porque la reacción (a) se lleva a cabo en un medio alcalino en un margen de pH de 11-13 preferiblemente de 12-13 y (b) a una temperatura relativamente vaja de aproximadamente 20-60ºC , preferiblemente de 30-40ºC y para ello © no se emplean ningún exceso, o solo un pequeño exceso de como máximo 0,5 moles, de formaldehido por cada mol de 4-metil-imidazol empleado.
ES477086A 1978-04-07 1979-01-23 Procedimiento para la preparacion de 4-metil-5-hidroximetil-imidazol. Expired ES477086A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH375578 1978-04-07

Publications (1)

Publication Number Publication Date
ES477086A1 true ES477086A1 (es) 1979-12-16

Family

ID=4262790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES477086A Expired ES477086A1 (es) 1978-04-07 1979-01-23 Procedimiento para la preparacion de 4-metil-5-hidroximetil-imidazol.

Country Status (6)

Country Link
US (1) US4189591A (es)
EP (1) EP0004534B1 (es)
JP (1) JPS54132570A (es)
DE (1) DE2960517D1 (es)
DK (1) DK145179A (es)
ES (1) ES477086A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2434807A1 (fr) * 1978-08-30 1980-03-28 Delalande Sa Procede perfectionne de preparation d'hydroxymethyl-4(5) alkyl inferieur-5 (4)-imidazoles et de leurs sels d'addition d'acide
DE2908212A1 (de) * 1979-03-02 1980-09-11 Basf Ag Verfahren zur herstellung von 5-hydroxymethylimidazolen
DE3426081A1 (de) * 1984-07-14 1986-01-16 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von 2-alkyl-4,5-dihydroxymethylimidazolen
IL75063A (en) * 1985-05-01 1989-03-31 Teva Pharma Preparation of 4(5)-hydroxymethyl-5(4)-methylimidazole
DE3534083A1 (de) * 1985-09-25 1987-04-02 Basf Ag Verfahren zur herstellung von hydroximethylimidazolen
US6107490A (en) * 1995-12-13 2000-08-22 Brantford Chemicals Inc. Process for the manufacture of 4-methyl-5-hydroxymethyl-imidazole
CN101914061A (zh) * 2010-08-04 2010-12-15 和夏化学(太仓)有限公司 2-苯基-(4)5-羟甲基咪唑类化合物的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5191262A (en) * 1974-12-27 1976-08-10 Shinkiimidazoorukagobutsuno seizoho
US4104473A (en) * 1976-04-23 1978-08-01 Shikoku Chemicals Corporation Novel imidazole compounds and process for preparations thereof

Also Published As

Publication number Publication date
DK145179A (da) 1979-10-08
DE2960517D1 (en) 1981-10-29
EP0004534B1 (de) 1981-07-29
JPS54132570A (en) 1979-10-15
EP0004534A1 (de) 1979-10-17
US4189591A (en) 1980-02-19

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