ES477523A1 - Un procedimiento para la preparacion de 17&-acetoxi-9&-fluo-ro-11b-hidroxi-16b-metil-3-oxoavidrosta-1,4-dieno-17b-carbo-xilato de clormetileno. - Google Patents

Un procedimiento para la preparacion de 17&-acetoxi-9&-fluo-ro-11b-hidroxi-16b-metil-3-oxoavidrosta-1,4-dieno-17b-carbo-xilato de clormetileno.

Info

Publication number: ES477523A1
Authority: ES; Spain
Prior art keywords: beta; chloromethyl; chloride; inflammations; acetylation
Prior art date: 1978-02-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES477523A

Other languages

English (en)

Spanish (es)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Glaxo Group Ltd

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-02-08

Filing date

1979-02-07

Publication date

1979-07-16

1979-02-07 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1979-07-16 Publication of ES477523A1 publication Critical patent/ES477523A1/es

Status Expired legal-status Critical Current

Links

-1 Cortisone compound Chemical class 0.000 title abstract 3
FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 title 1
MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 title 1
229960004544 cortisone Drugs 0.000 title 1
230000009885 systemic effect Effects 0.000 abstract 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
230000021736 acetylation Effects 0.000 abstract 1
238000006640 acetylation reaction Methods 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
229910052740 iodine Inorganic materials 0.000 abstract 1
239000011630 iodine Substances 0.000 abstract 1
229910001510 metal chloride Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Pharmacology & Pharmacy (AREA)
Pain & Pain Management (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ES477523A 1978-02-08 1979-02-07 Un procedimiento para la preparacion de 17&-acetoxi-9&-fluo-ro-11b-hidroxi-16b-metil-3-oxoavidrosta-1,4-dieno-17b-carbo-xilato de clormetileno. Expired ES477523A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB513178		1978-02-08

Publications (1)

Publication Number	Publication Date
ES477523A1 true ES477523A1 (es)	1979-07-16

Family

ID=9790294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES477523A Expired ES477523A1 (es)	1978-02-08	1979-02-07	Un procedimiento para la preparacion de 17&-acetoxi-9&-fluo-ro-11b-hidroxi-16b-metil-3-oxoavidrosta-1,4-dieno-17b-carbo-xilato de clormetileno.

Country Status (20)

Country	Link
JP (1)	JPS54145648A (de)
AT (1)	AT367771B (de)
AU (1)	AU520827B2 (de)
BE (1)	BE873996A (de)
CA (1)	CA1129407A (de)
CH (1)	CH639669A5 (de)
DE (1)	DE2904614A1 (de)
DK (1)	DK145578C (de)
ES (1)	ES477523A1 (de)
FI (1)	FI790403A7 (de)
FR (1)	FR2422688A1 (de)
IE (1)	IE47814B1 (de)
IL (1)	IL56613A (de)
IT (1)	IT1114534B (de)
NL (1)	NL7900967A (de)
NZ (1)	NZ189586A (de)
PT (1)	PT69192A (de)
SE (1)	SE435626B (de)
YU (1)	YU26779A (de)
ZA (1)	ZA79538B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE449106B (sv) *	1980-07-10	1987-04-06	Otsuka Pharma Co Ltd	Steroid med anti-inflammatorisk verkan samt komposition innehallande denna
US5237070A (en) *	1985-07-22	1993-08-17	Riker Laboratories, Inc.	Substituted DI-t-butylphenols
JP4847112B2 (ja) *	2005-11-29	2011-12-28	株式会社マキタ	園芸バリカン
US9290446B2 (en)	2010-10-27	2016-03-22	Hovione Inter Limited	Electrophilic reagents for monohalomethylation, their preparation and their uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1384372A (en) *	1971-01-20	1975-02-19	Glaxo Lab Ltd	Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) *	1972-07-19	1976-06-09	Glaxo Lab Ltd	17beta-haloalkoxycarbonyl-17alpha-oxysteroids

1979
- 1979-02-06 IT IT47909/79A patent/IT1114534B/it active
- 1979-02-07 IE IE236/79A patent/IE47814B1/en unknown
- 1979-02-07 JP JP1317379A patent/JPS54145648A/ja active Pending
- 1979-02-07 BE BE0/193318A patent/BE873996A/xx not_active IP Right Cessation
- 1979-02-07 DK DK50179A patent/DK145578C/da active
- 1979-02-07 NL NL7900967A patent/NL7900967A/xx not_active Application Discontinuation
- 1979-02-07 CA CA321,032A patent/CA1129407A/en not_active Expired
- 1979-02-07 ZA ZA79538A patent/ZA79538B/xx unknown
- 1979-02-07 PT PT7969192A patent/PT69192A/pt unknown
- 1979-02-07 CH CH121779A patent/CH639669A5/de not_active IP Right Cessation
- 1979-02-07 DE DE19792904614 patent/DE2904614A1/de not_active Withdrawn
- 1979-02-07 IL IL56613A patent/IL56613A/xx unknown
- 1979-02-07 FR FR7903085A patent/FR2422688A1/fr active Granted
- 1979-02-07 ES ES477523A patent/ES477523A1/es not_active Expired
- 1979-02-07 AT AT0092379A patent/AT367771B/de not_active IP Right Cessation
- 1979-02-07 SE SE7901100A patent/SE435626B/sv unknown
- 1979-02-07 YU YU00267/79A patent/YU26779A/xx unknown
- 1979-02-07 NZ NZ189586A patent/NZ189586A/xx unknown
- 1979-02-07 FI FI790403A patent/FI790403A7/fi unknown
- 1979-02-08 AU AU44084/79A patent/AU520827B2/en not_active Ceased

Also Published As

Publication number	Publication date
DK145578B (da)	1982-12-13
PT69192A (en)	1979-03-01
IL56613A (en)	1982-12-31
DE2904614A1 (de)	1979-08-09
AU4408479A (en)	1979-08-16
NL7900967A (nl)	1979-08-10
AT367771B (de)	1982-07-26
DK50179A (da)	1979-08-09
IT1114534B (it)	1986-01-27
BE873996A (fr)	1979-08-07
IE47814B1 (en)	1984-06-27
IT7947909A0 (it)	1979-02-06
CH639669A5 (en)	1983-11-30
DK145578C (da)	1983-05-09
JPS54145648A (en)	1979-11-14
YU26779A (en)	1983-01-21
FR2422688A1 (fr)	1979-11-09
IL56613A0 (en)	1979-05-31
FR2422688B1 (de)	1982-07-16
SE7901100L (sv)	1979-08-09
AU520827B2 (en)	1982-03-04
SE435626B (sv)	1984-10-08
ZA79538B (en)	1980-02-27
FI790403A7 (fi)	1979-08-09
IE790236L (en)	1979-08-08
ATA92379A (de)	1981-12-15
CA1129407A (en)	1982-08-10
NZ189586A (en)	1981-01-23

Publication	Publication Date	Title
GB1438940A (en)	1976-06-09	17beta-haloalkoxycarbonyl-17alpha-oxysteroids
NO843298L (no)	1985-02-19	Nye karboksylsyreestere
ES477523A1 (es)	1979-07-16	Un procedimiento para la preparacion de 17&-acetoxi-9&-fluo-ro-11b-hidroxi-16b-metil-3-oxoavidrosta-1,4-dieno-17b-carbo-xilato de clormetileno.
GB1495597A (en)	1977-12-21	Haloacylanilides as fungicidally active substances
JPS5575958A (en)	1980-06-07	Gelatinizing compositon
GB456147A (en)	1936-11-03	Improvements in or relating to the manufacture of unsaturated organie compounds
ES8106693A1 (es)	1981-07-01	Un procedimiento para preparar nuevos esteres carboxilicos de propiedades insecticidas
ATE19771T1 (de)	1986-05-15	Herstellungsverfahren von arylalkansaeureestern.
IE36529L (en)	1973-01-05	Esters of betamethasone
GB1294649A (en)	1972-11-01	Perfluoralkylmonocarboxylic acid esters, processes for their manufacture and their use
ES484380A1 (es)	1980-10-01	Un procedimiento no catalitico para la preparacion de deri- vados de cefalosporina
GB1409539A (en)	1975-10-08	Adenosine-5-carboxylate derivatives
DE3160214D1 (en)	1983-06-09	Process for the production of 3-bromo-4-fluorotoluene
GB843214A (en)	1960-08-04	Improvements in or relating to steroid compounds
KR830002769A (ko)	1983-05-30	6-β-치환된 페니실란산 유도체의 제조방법
FR2383184A1 (fr)	1978-10-06	Procede de preparation d'ethers
GB2014579A (en)	1979-08-30	Chloromethyl 17???-acetoxy-9???- fluoro-11-???-hydroxy-16???-methyl-3- oxoandrosta-1,4-diene-17???- carboxylate
GB1292662A (en)	1972-10-11	Bicycloheptaneheptanoic acids and esters thereof
GB803656A (en)	1958-10-29	Dehydrocortical hormones
GB1019569A (en)	1966-02-09	Esters of 1ª‡,2ª‡-methylene-í¸-androstene-3,17ª‰-diol and a process for their manufacture
GB1024802A (en)	1966-04-06	New derivatives of glycyrrhetinic acid
GB963964A (en)	1964-07-15	Improvements in or relating to the bromination of hecogenin and esters thereof
GB1234297A (de)	1971-06-03
FR2392955A1 (fr)	1978-12-29	Ester a-bisabololique d'acide farnesyl-carboxylique, agent de stabilisation des muqueuses, et procede pour sa fabrication
FR2359112A1 (fr)	1978-02-17	Nouvel ester d'acide phenoxyacetique