ES477741A1 - A procedure for preparing acetic acid derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for preparing acetic acid derivatives. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES477741A1
ES477741A1 ES477741A ES477741A ES477741A1 ES 477741 A1 ES477741 A1 ES 477741A1 ES 477741 A ES477741 A ES 477741A ES 477741 A ES477741 A ES 477741A ES 477741 A1 ES477741 A1 ES 477741A1
Authority
ES
Spain
Prior art keywords
formula
translation
acetic acid
machine
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES477741A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB14916/76A external-priority patent/GB1576625A/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES477741A1 publication Critical patent/ES477741A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. A process for preparing acetic acid derivatives of the formula: ** (Formula-01) ** in which R1 is a group of the formula: ** (Formula-02) ** in which R5 is hydrogen, halogen, nitro, hydroxy, lower alkoxy or acyloxy and R6 is hydroxy, lower alkoxy, acyloxy, acylamino or di-lower (alcohol) -animo, a group of the formula: ** (Formula-03) ** in which R7 is amino, protected amino, hydroxy or lower alcohol, or a group of the formula: ** (formula-04) ** in which R8 is lower alcohol and R9 is imino, protected imino or oxo, R2f is hydrogen or a group aliphatic hydrocarbon which may have a suitable substituent or substituents; and z a is protected carboxy; or salts thereof, a process comprising reacting a compound of the formula: ** (Formula-05) ** in which R1 and Za are each as defined above, or salts thereof, with a compound of the formula: ** (Formula-06) ** in which R2f is as defined above, or a salt thereof. (Machine-translation by Google Translate, not legally binding)
ES477741A 1976-04-12 1979-02-15 A procedure for preparing acetic acid derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES477741A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB14916/76A GB1576625A (en) 1976-04-12 1976-04-12 Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
GB2349076 1976-06-07
JP51125826A JPS5941995B2 (en) 1976-04-12 1976-10-19 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and salts thereof and methods for producing them

Publications (1)

Publication Number Publication Date
ES477741A1 true ES477741A1 (en) 1980-04-01

Family

ID=27257189

Family Applications (7)

Application Number Title Priority Date Filing Date
ES457191A Expired ES457191A1 (en) 1976-04-12 1977-03-25 A procedure for preparing the isomero without the compounds of 3-cefem-4-carboxylic acid replaced in positions 3 and 7. (Machine-translation by Google Translate, not legally binding)
ES468719A Expired ES468719A1 (en) 1976-04-12 1978-04-12 A procedure for preparing the isomero without the compounds of 3-cefem-4-carboxylic acid substituted in positions 3 and 7. (Machine-translation by Google Translate, not legally binding)
ES477741A Expired ES477741A1 (en) 1976-04-12 1979-02-15 A procedure for preparing acetic acid derivatives. (Machine-translation by Google Translate, not legally binding)
ES485063A Expired ES485063A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)
ES485061A Expired ES485061A1 (en) 1976-04-12 1979-10-16 A procedure for preparing the siomer without 3-cefem-4-carboxylic acid decomposition replaced in positions 3 and 7 (Machine-translation by Google Translate, not legally binding)
ES485064A Expired ES485064A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)
ES485062A Expired ES485062A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES457191A Expired ES457191A1 (en) 1976-04-12 1977-03-25 A procedure for preparing the isomero without the compounds of 3-cefem-4-carboxylic acid replaced in positions 3 and 7. (Machine-translation by Google Translate, not legally binding)
ES468719A Expired ES468719A1 (en) 1976-04-12 1978-04-12 A procedure for preparing the isomero without the compounds of 3-cefem-4-carboxylic acid substituted in positions 3 and 7. (Machine-translation by Google Translate, not legally binding)

Family Applications After (4)

Application Number Title Priority Date Filing Date
ES485063A Expired ES485063A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)
ES485061A Expired ES485061A1 (en) 1976-04-12 1979-10-16 A procedure for preparing the siomer without 3-cefem-4-carboxylic acid decomposition replaced in positions 3 and 7 (Machine-translation by Google Translate, not legally binding)
ES485064A Expired ES485064A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)
ES485062A Expired ES485062A1 (en) 1976-04-12 1979-10-16 A procedure for preparing acetic acid derivatives (Machine-translation by Google Translate, not legally binding)

Country Status (13)

Country Link
AR (2) AR227864A1 (en)
AT (1) AT358728B (en)
CA (1) CA1337522C (en)
CH (2) CH638532A5 (en)
DE (1) DE2707565A1 (en)
DK (1) DK162391C (en)
ES (7) ES457191A1 (en)
FR (1) FR2348219A1 (en)
HU (1) HU177441B (en)
IE (1) IE45597B1 (en)
MX (1) MX4985E (en)
NL (1) NL191259C (en)
SE (2) SE443981B (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3192167A (en) * 1962-09-20 1965-06-29 Ogawa Abiko Low pressure liquid vaporizer which is electrically heated
BE878514A (en) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co PROCESS FOR THE PREPARATION OF 3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS WITH DISUBSTITUTION IN POSITIONS 3 AND 7, NOVEL PRODUCTS THUS OBTAINED AND THEIR USE FOR THEIR ANTIBACTERIAL ACTIVITY
DE2715385A1 (en) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM
FR2381053A1 (en) * 1977-02-18 1978-09-15 Roussel Uclaf NEW OXIMES DERIVED FROM 3-THIADIAZOLYL THIOMETHYL 7-AMINOTHIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2399418A1 (en) * 1977-03-14 1979-03-02 Fujisawa Pharmaceutical Co Heterocyclyl-imino-acetamido-cephalosporin derivs.
PH17188A (en) 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (en) * 1977-03-25 1985-06-10 Roussel Uclaf SET TO MAKE NEW OXIME DERIVATIVES OF 3-ACETOXIMETHYL-7-AMINOTIAZOLYLACETAMIDO CEPHALOSPORANIC ACID
DE2714880A1 (en) * 1977-04-02 1978-10-26 Hoechst Ag CEPHEMDER DERIVATIVES AND PROCESS FOR THEIR PRODUCTION
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
FR2553770B2 (en) * 1978-03-31 1986-03-14 Roussel Uclaf NOVEL PRODUCTS DERIVED FROM ACID 2 (2-AMINO THIAZOL-4-YL) 2-ALCOXY-IMINO ACETIC SUBSTITUTED ON OXIME AND THEIR PREPARATION PROCESS
FR2432521A1 (en) * 1978-03-31 1980-02-29 Roussel Uclaf NOVEL O-SUBSTITUTED OXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS
FR2421907A1 (en) * 1978-04-07 1979-11-02 Roussel Uclaf NEW CEPHALOSPORINS DERIVED FROM 7- / 2- (2-AMINO 4-THIAZOLYL) 2- (CARBOXYMETHOXYIMINO / ACETAMIDO 3-SUBSTITUTE CEPHALOSPORANIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2438051A2 (en) * 1978-10-05 1980-04-30 Roussel Uclaf 3-Azido:methyl-3-cephem-4-carboxylic acid derivs. - useful as broad-spectrum antibacterial agents and disinfectants (BE 15.10.79)
MC1259A1 (en) * 1978-05-30 1980-01-14 Hoffmann La Roche ACYL DERIVATIVES
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
FR2453161A1 (en) * 1978-08-31 1980-10-31 Fujisawa Pharmaceutical Co Antibacterial amino-thiazolyl cephalosporin derivs.
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
DE2965943D1 (en) * 1978-10-17 1983-08-25 Fujisawa Pharmaceutical Co Cepham compounds, pharmaceutical compositions containing them and processes for the preparation thereof and of known cephem compounds
DE2945248A1 (en) * 1978-11-13 1980-05-22 Fujisawa Pharmaceutical Co CEPHEM COMPOUNDS, METHOD FOR THEIR PRODUCTION AND ANTIBACTERIAL PHARMACEUTICAL AGENTS CONTAINING THE SAME
FR2448543A1 (en) * 1979-02-09 1980-09-05 Roussel Uclaf NOVEL OXIMES O-SUBSTITUTED BY A RADICAL COMPRISING A QUATERNARY AMMONIUM AND DERIVATIVES OF 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICAMENTS
FR2461713A1 (en) * 1979-07-19 1981-02-06 Roussel Uclaf SUBSTITUTED ALKYLOXIMIC NEWS DERIVED FROM 7- (2-AMINO 4-THIAZOLYL) ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS
FR2462439A1 (en) * 1979-07-26 1981-02-13 Roussel Uclaf NOVEL PROCESS FOR THE PREPARATION OF PRODUCTS DERIVED FROM 7 - / (2-ARYL) 2-HYDROXYIMINO ACETAMIDO / CEPHALOSPORANIC ACID
IL61458A0 (en) * 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
FR2506307A1 (en) * 1981-05-22 1982-11-26 Roussel Uclaf 7-thiazolyl-acetamido-cephalosporin oxime derivs. - useful as broad spectrum antibacterials and disinfectants (BE 1.10.79)
US4426528A (en) * 1982-04-01 1984-01-17 Eli Lilly And Company Purification of syn-(2-aminothiazol-4-yl)methoxyimino)acetic acid
FR2532936A1 (en) * 1982-09-13 1984-03-16 Roussel Uclaf New 2-aminothiazolyl-4-ylacetic acid derivatives containing a substituted oxime functional group and process for their preparation.
GB8324152D0 (en) * 1983-09-09 1983-10-12 Glaxo Group Ltd Chemical process
IT8448798A0 (en) * 1983-09-12 1984-09-05 Biochemie Gmbh PROCEDURE FOR THE PREPARATION OF CEPHALOSPORIN-TYPE ANTIBIOTICS
GB2161476B (en) * 1984-05-25 1988-01-27 Toyama Chemical Co Ltd 2-aminothiazolyl-2-methoxyimino acetamides and their use in preparing cephalosporins
EP0241901B1 (en) * 1986-04-14 1994-08-24 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
DK154939C (en) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd METHOD OF ANALOGUE FOR THE PREPARATION OF THIAZOLYLACETAMIDO-CEPHEM COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE SALTS OR ESTERS THEREOF
FI66005C (en) * 1975-02-04 1984-08-10 Fujisawa Pharmaceutical Co FRUIT PROTECTION FOR ANTIBACTERIAL VERIFICATION OF 7-ALPHA ALPHA-DISUBSTITUTE-ACETAMIDO) -3-SUBSTITUTER-3-CEFE M - CARBOXYL SYRINE SYN-ISOMER
FR2346014A1 (en) * 1976-01-23 1977-10-28 Roussel Uclaf Amino-thiazolyl-hydroxyimino-acetamido-cephalosporanic acids - with antibacterial activity
DE2760123C2 (en) * 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporanic acids, their preparation and pharmaceutical compositions containing them
SE440655B (en) * 1976-01-23 1985-08-12 Roussel Uclaf SET TO MAKE NEW OXIME DERIVATIVES OF 7-AMINO-THIAZOLYL-ACETAMIDO-CEPHALOSPORANIC ACID
FR2345153A1 (en) * 1976-03-25 1977-10-21 Roussel Uclaf NEW ALCOYLOXIMES DERIVED FROM 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
DE2715385A1 (en) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd CEPHALOSPORIN DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THEM

Also Published As

Publication number Publication date
HU177441B (en) 1981-10-28
SE7701964L (en) 1977-10-13
CH638532A5 (en) 1983-09-30
ES485064A1 (en) 1980-10-01
NL7703969A (en) 1977-10-14
SE8304465D0 (en) 1983-08-17
SE443981B (en) 1986-03-17
DK162391C (en) 1992-03-09
DE2707565C2 (en) 1988-06-30
ATA138477A (en) 1980-02-15
MX4985E (en) 1983-01-31
DK162391B (en) 1991-10-21
ES485061A1 (en) 1980-06-16
ES485062A1 (en) 1980-06-16
ES457191A1 (en) 1978-08-16
NL191259C (en) 1995-04-18
CA1337522C (en) 1995-11-07
ES485063A1 (en) 1980-06-16
SE457351B (en) 1988-12-19
FR2348219A1 (en) 1977-11-10
DK75077A (en) 1977-10-13
CH643557A5 (en) 1984-06-15
FR2348219B1 (en) 1982-12-03
AR223143A1 (en) 1981-07-31
IE45597L (en) 1977-10-12
DE2707565A1 (en) 1978-02-23
AT358728B (en) 1980-09-25
IE45597B1 (en) 1982-10-06
NL191259B (en) 1994-11-16
AR227864A1 (en) 1982-12-30
ES468719A1 (en) 1979-10-16

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