ES478202A1 - Guanidine derivatives - Google Patents

Guanidine derivatives

Info

Publication number
ES478202A1
ES478202A1 ES478202A ES478202A ES478202A1 ES 478202 A1 ES478202 A1 ES 478202A1 ES 478202 A ES478202 A ES 478202A ES 478202 A ES478202 A ES 478202A ES 478202 A1 ES478202 A1 ES 478202A1
Authority
ES
Spain
Prior art keywords
antagonists
chain
guanidine derivatives
histamine
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES478202A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/848,959 external-priority patent/US4112234A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES478202A1 publication Critical patent/ES478202A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Antagonists of histamine H2 receptors, which antagonists inhibit gastric secretion in animals and are suitable for treating ulcerous disorders, have the following formula < IMAGE > in which R<2> represents a straight-chain or branched-chain alkynyl group having 3-9 C atoms, including non-toxic, pharmaceutically useful, acid addition salts thereof. Starting materials for preparing the said compounds and processes for their preparation.
ES478202A 1977-06-03 1979-03-01 Guanidine derivatives Expired ES478202A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80300977A 1977-06-03 1977-06-03
US82679677A 1977-08-22 1977-08-22
US05/848,959 US4112234A (en) 1977-08-22 1977-11-07 Imidazolylmethylthioethyl alkynyl guanidines

Publications (1)

Publication Number Publication Date
ES478202A1 true ES478202A1 (en) 1979-06-01

Family

ID=27419995

Family Applications (3)

Application Number Title Priority Date Filing Date
ES470474A Expired ES470474A1 (en) 1977-06-03 1978-06-02 Guanidine derivatives
ES478203A Expired ES478203A1 (en) 1977-06-03 1979-03-01 Guanidine derivatives
ES478202A Expired ES478202A1 (en) 1977-06-03 1979-03-01 Guanidine derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES470474A Expired ES470474A1 (en) 1977-06-03 1978-06-02 Guanidine derivatives
ES478203A Expired ES478203A1 (en) 1977-06-03 1979-03-01 Guanidine derivatives

Country Status (26)

Country Link
JP (1) JPS543067A (en)
AR (2) AR222797A1 (en)
CA (1) CA1110251A (en)
CH (2) CH641167A5 (en)
CY (3) CY1230A (en)
DD (1) DD140038A5 (en)
DE (1) DE2824066A1 (en)
DK (1) DK243178A (en)
ES (3) ES470474A1 (en)
FI (1) FI69069C (en)
FR (2) FR2401143A1 (en)
GB (3) GB1598628A (en)
GR (1) GR73860B (en)
HK (3) HK38284A (en)
HU (1) HU186766B (en)
IE (1) IE47543B1 (en)
IL (1) IL54819A (en)
KE (1) KE3373A (en)
LU (1) LU79725A1 (en)
MY (3) MY8500453A (en)
NL (1) NL7805935A (en)
NO (3) NO152214C (en)
NZ (1) NZ187376A (en)
SE (3) SE443784B (en)
SG (1) SG8584G (en)
YU (4) YU129778A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS568352A (en) * 1979-07-03 1981-01-28 Shionogi & Co Ltd Aminoalkylvenzene derivative
US4339439A (en) * 1981-01-19 1982-07-13 Bristol-Myers Company Pharmaceutical methods and compositions
JPS6018010U (en) * 1983-07-18 1985-02-07 日産自動車株式会社 Temperature adjustment mechanism of vehicle air conditioner
JPS60113211U (en) * 1984-01-06 1985-07-31 松下電器産業株式会社 Automotive air conditioner
ES2007948A6 (en) * 1988-07-06 1989-07-01 Vinas Lab Propargylguanidine derivatives and process for the preparation thereof.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024271A (en) * 1971-03-09 1977-05-17 Smith Kline & French Laboratories Limited Pharmacologically active guanidine compounds
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines
GB1531221A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for preparing guanidine derivatives
GB1531231A (en) * 1974-09-02 1978-11-08 Smith Kline French Lab Process for the production of cyanoguanidine derivatives
GB1533380A (en) * 1974-09-02 1978-11-22 Smith Kline French Lab Process for the preparation of heterocyclic substituted thioureas and h-cyanoguanidines

Also Published As

Publication number Publication date
FR2401143B1 (en) 1981-12-11
IE781112L (en) 1978-12-03
HK38284A (en) 1984-05-11
CY1230A (en) 1984-06-29
LU79725A1 (en) 1979-02-02
JPS543067A (en) 1979-01-11
KE3373A (en) 1984-03-23
JPS5639313B2 (en) 1981-09-11
FI781737A7 (en) 1978-12-04
NO151824B (en) 1985-03-04
GR73860B (en) 1984-05-08
GB1598628A (en) 1981-09-23
NO152214C (en) 1985-08-28
HK38084A (en) 1984-05-11
ES470474A1 (en) 1979-09-01
AR222797A1 (en) 1981-06-30
YU40625B (en) 1986-02-28
GB1598629A (en) 1981-09-23
CY1231A (en) 1984-06-29
NO791637L (en) 1978-12-05
FR2401143A1 (en) 1979-03-23
NO152214B (en) 1985-05-13
SE8401492L (en) 1984-03-16
IL54819A (en) 1983-03-31
MY8500451A (en) 1985-12-31
GB1598630A (en) 1981-09-23
SE8401491D0 (en) 1984-03-16
YU215582A (en) 1983-02-28
AR222503A1 (en) 1981-05-29
SE8401492D0 (en) 1984-03-16
YU129778A (en) 1983-02-28
NO833255L (en) 1978-12-05
NO151824C (en) 1985-06-12
NZ187376A (en) 1981-05-29
ES478203A1 (en) 1979-06-01
FR2436138A1 (en) 1980-04-11
FI69069B (en) 1985-08-30
CH641167A5 (en) 1984-02-15
IL54819A0 (en) 1978-07-31
IE47543B1 (en) 1984-04-18
HU186766B (en) 1985-09-30
CH644591A5 (en) 1984-08-15
CY1229A (en) 1984-06-29
SE7806525L (en) 1978-12-04
FI69069C (en) 1985-12-10
YU41620B (en) 1987-12-31
YU53079A (en) 1983-09-30
SG8584G (en) 1985-02-08
YU40624B (en) 1986-02-28
SE443784B (en) 1986-03-10
DD140038A5 (en) 1980-02-06
CA1110251A (en) 1981-10-06
NL7805935A (en) 1978-12-05
NO781928L (en) 1978-12-05
MY8500453A (en) 1985-12-31
DE2824066A1 (en) 1978-12-14
MY8500452A (en) 1985-12-31
HK38184A (en) 1984-05-11
DK243178A (en) 1978-12-04
FR2436138B1 (en) 1982-12-03
YU215482A (en) 1983-02-28
SE8401491L (en) 1984-03-16

Similar Documents

Publication Publication Date Title
JPS5622770A (en) Amidine derivative and its preparation
KR920008006A (en) Unsaturated hydroxy alkylquinolinic acid as a leukotriene antagonist
BG60249B2 (en) Thiazole compound for treatment of ulcers
CA2040086A1 (en) Novel 2,9-disubstituted-4h-pyrido[1,2-a]pyrimidin-4-ones
EP0091749A3 (en) Ethanolamine derivatives, process for their preparation and pharmaceutical compositions containing them
EP0138344A3 (en) Pyridazinones as beta-adrenoceptor antagonists
ES470474A1 (en) Guanidine derivatives
KR910018383A (en) Difluoroglutamic Acid Conjugate with Folate and Antifolate for Treatment of Tumor Disease
ES477785A1 (en) 2-Phenylimino-imidazolidines and salts thereof
EP0071521A3 (en) Pyrid-3-yl or pyridin-3-yl-oxo-2-indole derivatives, their salts, process for their preparation, compositions containing them and their uses as medicines
DE3266036D1 (en) 3-piperidinylindole derivatives, their salts and preparation, their use in medicines and pharmaceutical preparations containing them
ES484524A1 (en) Halogenated 1-azolyl-1-fluorophenoxy butanes, process for their preparation, fungicides comprising them as well as their use as fungicides.
ES526026A0 (en) A PROCEDURE TO PREPARE NEW ACID DERIVATIVES -ARIL- -PIRIDILALCANOICO
IE37579B1 (en) Benzodioxan compounds and process for preparing the same
GB1505849A (en) 9,10-dihydroanthracen-9,10-imine derivatives
ES529251A0 (en) A PROCEDURE FOR THE PREPARATION OF NEW TRIAZOL DERIVATIVES.
IE801785L (en) 2-(2-chloro-4-cyclopropyl-phenyl-imino) imidazolidine
PT66874A (en) Process for the preparation of new aminoalquil furan derivatives
ES8103774A1 (en) A PROCEDURE FOR PREPARING NEW TRIAZENE COMPOUNDS
ES489925A1 (en) PROCEDURE FOR THE PREPARATION OF N, N&#39;-DIPHENYL-MONOHIDRA-ZIDA ACID 2- (3-METHYL-3-BUTENYL) -MALONIC
JPS51146474A (en) Process for preparing piperidylbenzimidazole derivatives
MY102089A (en) Antibacterial compounds.
JPS5436282A (en) Preparation of substituted piperazine
ES485333A1 (en) 5,6,7,8-Tetrahydro-4(3H)- quinazolinone derivatives useful as spasmolytics
ES466677A1 (en) Therapeutically useful cysteinol and homocysteinol derivatives