ES479448A1 - Procedimiento de preparacion de nuevas piperazinas monosus- tituidas y de sus sales de adicion con acidos convenientes. - Google Patents
Procedimiento de preparacion de nuevas piperazinas monosus- tituidas y de sus sales de adicion con acidos convenientes.Info
- Publication number
- ES479448A1 ES479448A1 ES479448A ES479448A ES479448A1 ES 479448 A1 ES479448 A1 ES 479448A1 ES 479448 A ES479448 A ES 479448A ES 479448 A ES479448 A ES 479448A ES 479448 A1 ES479448 A1 ES 479448A1
- Authority
- ES
- Spain
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compositions containing
- thiazolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Monosubstituted piperazines Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- GEQLCTCVWQBSGG-UHFFFAOYSA-N 4-[(4-phenylphenyl)methyl]-2-piperazin-1-yl-1,3-thiazole Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1CC(N=1)=CSC=1N1CCNCC1 GEQLCTCVWQBSGG-UHFFFAOYSA-N 0.000 abstract 1
- SJYUKNQSAKHFEU-UHFFFAOYSA-N 4-[[4-(benzenesulfinyl)phenyl]methyl]-2-piperazin-1-yl-1,3-thiazole Chemical compound C=1C=C(CC=2N=C(SC=2)N2CCNCC2)C=CC=1S(=O)C1=CC=CC=C1 SJYUKNQSAKHFEU-UHFFFAOYSA-N 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 239000003529 anticholesteremic agent Substances 0.000 abstract 1
- 239000003524 antilipemic agent Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
Procedimiento de preparación de nuevas piperazinas monosustituidas, de fórmula general: ***
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1456578 | 1978-04-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES479448A1 true ES479448A1 (es) | 1979-07-16 |
Family
ID=10043524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479448A Expired ES479448A1 (es) | 1978-04-13 | 1979-04-09 | Procedimiento de preparacion de nuevas piperazinas monosus- tituidas y de sus sales de adicion con acidos convenientes. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US4479952A (es) |
| EP (1) | EP0005091B1 (es) |
| JP (1) | JPS5936987B2 (es) |
| AU (1) | AU518679B2 (es) |
| CA (1) | CA1132983A (es) |
| DE (1) | DE2961406D1 (es) |
| ES (1) | ES479448A1 (es) |
| GR (1) | GR66585B (es) |
| IL (1) | IL57062A0 (es) |
| OA (1) | OA06235A (es) |
| PT (1) | PT69475A (es) |
| ZA (1) | ZA791759B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT41752A (en) * | 1984-11-30 | 1987-05-28 | Sandoz Ag | Process for producing piperazine derivatives and pharmaceutical compositions containing them |
| JPS63152368A (ja) * | 1986-06-03 | 1988-06-24 | Sumitomo Pharmaceut Co Ltd | 新規なアミノアゾ−ル誘導体およびその酸付加塩 |
| US5180731A (en) * | 1986-06-03 | 1993-01-19 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
| US4914112A (en) * | 1986-06-03 | 1990-04-03 | Sumitomo Pharmaceuticals Company, Limited | Aminoazole derivatives and their production and use |
| JPS6331788U (es) * | 1986-08-15 | 1988-03-01 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1595923A1 (de) * | 1965-02-20 | 1969-11-27 | Merck Ag E | 1-Aralkyl-4-(thiazolyl-2)-piperazine und Verfahren zu ihrer Herstellung |
| GB1518559A (en) * | 1976-04-12 | 1978-07-19 | Science Union & Cie | Naphthyl derivatives processes for their preparation an pharmaceutical compositions containing them |
| US4123529A (en) * | 1976-04-23 | 1978-10-31 | Lilly Industries Limited | Phenylpiperazine derivatives |
| NZ187474A (en) * | 1977-06-10 | 1981-03-16 | Science Union & Cie | 4-heterocyclyl-piperazine-i-carbodithioic acids and salts and pharmaceutical compositions thereof |
-
1979
- 1979-03-27 EP EP79400193A patent/EP0005091B1/fr not_active Expired
- 1979-03-27 DE DE7979400193T patent/DE2961406D1/de not_active Expired
- 1979-04-09 ES ES479448A patent/ES479448A1/es not_active Expired
- 1979-04-09 CA CA325,182A patent/CA1132983A/fr not_active Expired
- 1979-04-09 US US06/028,049 patent/US4479952A/en not_active Expired - Lifetime
- 1979-04-11 AU AU46014/79A patent/AU518679B2/en not_active Ceased
- 1979-04-11 IL IL57062A patent/IL57062A0/xx unknown
- 1979-04-11 PT PT69475A patent/PT69475A/pt unknown
- 1979-04-12 ZA ZA791759A patent/ZA791759B/xx unknown
- 1979-04-12 OA OA56786A patent/OA06235A/xx unknown
- 1979-04-12 GR GR58873A patent/GR66585B/el unknown
- 1979-04-12 JP JP54044849A patent/JPS5936987B2/ja not_active Expired
-
1980
- 1980-09-11 US US06/186,273 patent/US4312869A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE2961406D1 (en) | 1982-01-28 |
| IL57062A0 (en) | 1979-07-25 |
| EP0005091A1 (fr) | 1979-10-31 |
| OA06235A (fr) | 1981-06-30 |
| US4312869A (en) | 1982-01-26 |
| US4479952A (en) | 1984-10-30 |
| JPS54135784A (en) | 1979-10-22 |
| AU4601479A (en) | 1979-10-18 |
| AU518679B2 (en) | 1981-10-15 |
| CA1132983A (fr) | 1982-10-05 |
| JPS5936987B2 (ja) | 1984-09-06 |
| ZA791759B (en) | 1980-04-30 |
| EP0005091B1 (fr) | 1981-11-25 |
| GR66585B (es) | 1981-03-30 |
| PT69475A (fr) | 1979-05-01 |
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