ES479570A1 - Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina. - Google Patents
Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina.Info
- Publication number
- ES479570A1 ES479570A1 ES479570A ES479570A ES479570A1 ES 479570 A1 ES479570 A1 ES 479570A1 ES 479570 A ES479570 A ES 479570A ES 479570 A ES479570 A ES 479570A ES 479570 A1 ES479570 A1 ES 479570A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- unsubstituted
- substituents
- alpha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 benzenesulphonyloxy group Chemical group 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 150000004820 halides Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- LXWBXEWUSAABOA-UHFFFAOYSA-N Cephamycin-C Natural products S1CC(COC(N)=O)=C(C(O)=O)N2C(=O)C(OC)(NC(=O)CCCC(N)C(O)=O)C21 LXWBXEWUSAABOA-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- LXWBXEWUSAABOA-VXSYNFHWSA-N cephamycin C Chemical compound S1CC(COC(N)=O)=C(C(O)=O)N2C(=O)[C@@](OC)(NC(=O)CCC[C@@H](N)C(O)=O)[C@H]21 LXWBXEWUSAABOA-VXSYNFHWSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Derivados de 7alfa-metoxicefalosporina de fórmula general (I): **(Fórmula)** donde: R1 representa un grupo hidroxi; un grupo alcoxi C1-C4; un grupo aciloxi alifático C2-C3; un grupo benzoiloxi que no está sustituido o contiene uno o más sustituyentes alquilo C1-C4, alcoxi C1-C4, nitro o halógeno; un grupo bencenosulfoniloxi que no está sustituido o contiene uno o más sustituyentes alquilo C1-C4; o un grupo alcanosulfoniloxi C1-C3 que no está sustituido o contiene uno o más sustituyentes alcoxi C1-C3, ciano, nitro, halógeno o alcoxicarbonilo C2-C4; R2 representa un átomo de hidrógeno, un grupo alquilo C1-C4, un átomo de halógeno, un grupo carboxilo, un grupo alcoxicarbonilo C2-C5, un grupo carbamoílo, un grupo alquilcarbamoílo donde el radical alquilo contiene de 1 a 3 átomos de carbono, un grupo di (alquil-C1-C3) carbamoílo o un grupo ciano; R3 representa un átomo de hidrógeno; un grupo acetoxi; un grupo carbamoiloxi; o un grupo tetrazoliltio, tiadiazoliltio u oxadiazoliltio que no está sustituido o contiene uno o más sustituyentes alquilo C1-C3, sulfometilo o di (alquil C1 o C2) amino (alquilo C1-C3); m es 0 o 1 y n es 0 o 2, presentan intensa actividad antibacteriana y, por lo tanto, son útiles como medicinas. Los derivados pueden prepararse por reacción del correspondiente derivado de 7 alfa-metoxicefalosporina con un grupo amino en la posición 7beta con un haluro de ácido correspondiente al grupo acetilo sustituido que se desea unir al grupo amino de la posición 7 beta o por reacción de cefamicina C con el mismo haluro de ácido
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53042360A JPS6052713B2 (ja) | 1978-04-11 | 1978-04-11 | ７−メトキシセフアロスポリン化合物、その製法及びその化合物を主成分とする抗菌剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES479570A1 true ES479570A1 (es) | 1979-12-01 |
Family
ID=12633858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES479570A Expired ES479570A1 (es) | 1978-04-11 | 1979-04-11 | Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4247548A (es) |
| JP (1) | JPS6052713B2 (es) |
| DE (1) | DE2914843A1 (es) |
| ES (1) | ES479570A1 (es) |
| FR (1) | FR2422667A1 (es) |
| GB (1) | GB2018247B (es) |
| NL (1) | NL7902863A (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5793968A (en) * | 1980-11-11 | 1982-06-11 | Sankyo Co Ltd | Carbamic acid ester and insecticide containing the same |
| US4394504A (en) | 1981-10-07 | 1983-07-19 | American Home Products Corporation | Cephalosporin derivatives |
| US4562187A (en) * | 1985-01-22 | 1985-12-31 | Hoechst-Roussel Pharmaceuticals Inc. | (Isoxazol-3-yl)arylmethanones, compositions and pharmaceutical use |
| JPH0282123U (es) * | 1988-12-09 | 1990-06-25 | ||
| US5650533A (en) * | 1989-09-11 | 1997-07-22 | Rhone-Poulenc Agriculture Ltd. | Intermediates to herbicidal 4-substituted isoxazoles |
| US5656573A (en) * | 1989-09-11 | 1997-08-12 | Rhone-Poulenc Agriculture Ltd. | Herbicidal 4-substituted isoxazoles |
| US5747424A (en) * | 1989-09-11 | 1998-05-05 | Rhone-Poulenc Agriculture Ltd. | Herbicidal 4-substituted isoxazol |
| GB9017539D0 (en) * | 1990-08-10 | 1990-09-26 | Rhone Poulenc Agriculture | New compositions of matter |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1348985A (en) * | 1970-06-16 | 1974-03-27 | Merck & Co Inc | Esters of cephalosporin compounds |
| US4010264A (en) * | 1970-11-06 | 1977-03-01 | Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V. | 7-[3-Substituted isoxazol-5-yl]-acetamido-cephalosporanic acids and their anti-bacterial use |
| GB1364453A (en) * | 1970-11-06 | 1974-08-21 | Gist Brocades Nv | Penicillanic and cepholosporanic acid derivatives |
| FR2219775A1 (en) * | 1973-03-02 | 1974-09-27 | Gist Brocades Nv | Isoxazolylacetamido penicillanic and cephalosporanic acids - partic. active against Gram-positive bacteria |
| GB1449420A (en) * | 1973-11-26 | 1976-09-15 | Sankyo Co | 7alpha-methoxycephalosporing derivatives |
| US3960845A (en) * | 1974-03-22 | 1976-06-01 | Sankyo Company Limited | Process for preparing 7β-acylamino-7α-alkoxycephalosporins or 6β-acylamino-6α-alkoxypenicillins |
| JPS5165789A (en) * | 1974-11-30 | 1976-06-07 | Sankyo Co | 77 metokishisefuarosuhorinkagobutsuno seiho |
-
1978
- 1978-04-11 JP JP53042360A patent/JPS6052713B2/ja not_active Expired
-
1979
- 1979-04-10 US US06/028,707 patent/US4247548A/en not_active Expired - Lifetime
- 1979-04-11 DE DE19792914843 patent/DE2914843A1/de not_active Withdrawn
- 1979-04-11 ES ES479570A patent/ES479570A1/es not_active Expired
- 1979-04-11 NL NL7902863A patent/NL7902863A/xx not_active Application Discontinuation
- 1979-04-11 FR FR7909148A patent/FR2422667A1/fr active Granted
- 1979-04-11 GB GB7912861A patent/GB2018247B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7902863A (nl) | 1979-10-15 |
| DE2914843A1 (de) | 1979-10-18 |
| US4247548A (en) | 1981-01-27 |
| GB2018247B (en) | 1982-09-02 |
| FR2422667B1 (es) | 1982-12-03 |
| JPS54138590A (en) | 1979-10-27 |
| FR2422667A1 (fr) | 1979-11-09 |
| GB2018247A (en) | 1979-10-17 |
| JPS6052713B2 (ja) | 1985-11-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR870006072A (ko) | 라파마이신 전구체의 제조방법 | |
| ES469953A1 (es) | Un procedimiento para la preparacion de nuevos derivados de aminoalquilbenceno | |
| IE41528L (en) | Furfuryl-benzomorphane derivatives. | |
| ES405983A1 (es) | Procedimiento para la preparacion de derivados de fenileti-lamina fluoralcohilados. | |
| ES394370A1 (es) | Procedimiento para la preparacion de derivados de la inso-indolina. | |
| ES479570A1 (es) | Un procedimiento para la preparacion de derivaciones 7 &-me-toxicefalosporina. | |
| GB1207371A (en) | Cyclopropane carboxylic acids and derivatives thereof having insecticidal properties | |
| GB1289283A (es) | ||
| GB1408198A (en) | Antiviral compositions | |
| GB1169945A (en) | Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives | |
| ES421098A1 (es) | Un metodo para la preparacion de tiaxantenos fluor-susti- tuidos. | |
| GB999583A (en) | Pharmaceutical preparations containing trihydroxamic acids | |
| ES397453A1 (es) | Procedimiento para la preparacion de derivados de imidazo- lina. | |
| ES441775A1 (es) | Procedimiento para preparar colorantes antraquinonicos solu-bles en agua. | |
| KR850700244A (ko) | 세팔로스포린 유도체 및 그 염의 제조방법 | |
| ES386554A1 (es) | Procedimiento para preparar derivados de propanolamina. | |
| KR920700210A (ko) | 신규 이미다졸 유도체, 그의 제법 및 그의 의약용도 | |
| GB1156774A (en) | Novel Derivatives of Iodinated Benzylamine and a Process for Producing same | |
| ES430905A1 (es) | Un procedimiento para la preparacion de derivados de cuma- rina. | |
| ES488388A1 (es) | Procedimiento de preparacion de derivados hidroxilados del tiazol | |
| ES405048A1 (es) | Procedimiento para la obtencion de derivados de la fenotia-zina. | |
| GB1420758A (en) | Anti-ulcer compositions | |
| GB1107036A (en) | Esters of dibenzocycloheptenyl-carboxylic acids | |
| GB1420759A (en) | Piperidine derivatives | |
| ES306443A1 (es) | Procedimiento de preparaciën de derivados de quinoleina |