ES479832A1 - A PROCEDURE FOR PREPARING MERCAPTOACILAMINO ACIDS SUBSTITUTED WITH HALAGEN. - Google Patents
A PROCEDURE FOR PREPARING MERCAPTOACILAMINO ACIDS SUBSTITUTED WITH HALAGEN.Info
- Publication number
- ES479832A1 ES479832A1 ES479832A ES479832A ES479832A1 ES 479832 A1 ES479832 A1 ES 479832A1 ES 479832 A ES479832 A ES 479832A ES 479832 A ES479832 A ES 479832A ES 479832 A1 ES479832 A1 ES 479832A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- mercaptoacilamino
- halagen
- preparing
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical group 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Compounds which have the general formula (I> < IMAGE > wherein R is hydrogen, lower alkanoyl or < IMAGE > m is 1 or 2 n is 0 or 1 R1 is hydrogen or lower alkyl R2 and R'2 each is hydrogen or halogen R3 is hydrogen, lower alkyl or CF3, and also halogen when n is 1 R4 is hydrogen, lower alkyl or trifluoromethyl R6 is hydrogen, and also halogen when m is 1 at least one of R2, R'2, R3, R4 and R6 being halogen or CF3 as represented by the symbols and only R2 and R'2 can both be halogen at the same time, and basic salts thereof may be used as hypotensive agents.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87903278A | 1978-02-21 | 1978-02-21 | |
| US93914878A | 1978-09-01 | 1978-09-01 | |
| US05/939,147 US4154935A (en) | 1978-02-21 | 1978-09-01 | Halogen substituted mercaptoacylamino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES479832A1 true ES479832A1 (en) | 1979-11-16 |
Family
ID=27420501
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES477878A Expired ES477878A1 (en) | 1978-02-21 | 1979-02-20 | Mercaptoacylamino acids |
| ES479833A Expired ES479833A1 (en) | 1978-02-21 | 1979-04-23 | A PROCEDURE FOR PREPARING MERCATOACILAMINO ACIDS SUBSTITUTED WITH HALOGEN. |
| ES479832A Expired ES479832A1 (en) | 1978-02-21 | 1979-04-23 | A PROCEDURE FOR PREPARING MERCAPTOACILAMINO ACIDS SUBSTITUTED WITH HALAGEN. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES477878A Expired ES477878A1 (en) | 1978-02-21 | 1979-02-20 | Mercaptoacylamino acids |
| ES479833A Expired ES479833A1 (en) | 1978-02-21 | 1979-04-23 | A PROCEDURE FOR PREPARING MERCATOACILAMINO ACIDS SUBSTITUTED WITH HALOGEN. |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS54125656A (en) |
| AR (2) | AR229152A1 (en) |
| CA (1) | CA1124723A (en) |
| CH (1) | CH639370A5 (en) |
| CS (1) | CS230562B2 (en) |
| DD (1) | DD141827A5 (en) |
| DE (1) | DE2906768A1 (en) |
| DK (1) | DK73379A (en) |
| ES (3) | ES477878A1 (en) |
| FI (1) | FI790593A7 (en) |
| FR (1) | FR2417499A1 (en) |
| GB (1) | GB2014987B (en) |
| GR (1) | GR82336B (en) |
| HK (1) | HK41383A (en) |
| IE (1) | IE47971B1 (en) |
| IL (1) | IL56662A0 (en) |
| LU (1) | LU80946A1 (en) |
| NL (1) | NL7901319A (en) |
| NO (1) | NO790568L (en) |
| NZ (1) | NZ189626A (en) |
| PH (1) | PH15381A (en) |
| PL (1) | PL118158B1 (en) |
| PT (1) | PT69254A (en) |
| RO (1) | RO77228A (en) |
| SE (1) | SE431643B (en) |
| SU (1) | SU882409A3 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1144930A (en) * | 1978-08-11 | 1983-04-19 | Miguel A. Ondetti | Mercaptoacyl derivatives of substituted prolines |
| NL7809120A (en) * | 1978-09-07 | 1980-03-11 | Oce Andeno B V Grubbenvorsterw | PROCESS FOR THE PREPARATION OF PROLINE DERIVATIVES. |
| US4483861A (en) * | 1978-10-31 | 1984-11-20 | Santen Pharmaceutical Co., Ltd. | Antihypertensive sulfur-containing compounds |
| CA1132985A (en) * | 1978-12-22 | 1982-10-05 | John Krapcho | Ketal and thioketal derivatives of mercaptoacyl prolines |
| ZA802420B (en) * | 1979-05-18 | 1981-04-29 | Squibb & Sons Inc | Aminoacyl derivatives of mercaptoacyl amino acids |
| US4288368A (en) * | 1979-07-30 | 1981-09-08 | E. R. Squibb & Sons, Inc. | Dithioacylproline derivatives |
| AU542211B2 (en) * | 1980-03-07 | 1985-02-14 | Gruppo Lepetit S.P.A. | Mercaptocycloalkyl carbonyl prolines |
| JP2005213165A (en) * | 2004-01-28 | 2005-08-11 | Mitsui Chemicals Inc | Method for producing fluoroproline compounds |
| JP2011121872A (en) * | 2009-12-08 | 2011-06-23 | Central Glass Co Ltd | Method for purifying optically active n-tert-butoxycarbonyl-trans-4-fluoroproline |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU509899B2 (en) * | 1976-02-13 | 1980-05-29 | E.R. Squibb & Sons, Inc. | Proline derivatives and related compounds |
-
1970
- 1970-02-15 PH PH22197A patent/PH15381A/en unknown
-
1979
- 1979-02-08 CA CA321,233A patent/CA1124723A/en not_active Expired
- 1979-02-12 NZ NZ189626A patent/NZ189626A/en unknown
- 1979-02-13 GR GR58343A patent/GR82336B/el unknown
- 1979-02-14 IL IL56662A patent/IL56662A0/en not_active IP Right Cessation
- 1979-02-15 IE IE297/79A patent/IE47971B1/en not_active IP Right Cessation
- 1979-02-19 GB GB7905788A patent/GB2014987B/en not_active Expired
- 1979-02-20 PT PT69254A patent/PT69254A/en unknown
- 1979-02-20 CS CS791134A patent/CS230562B2/en unknown
- 1979-02-20 NO NO790568A patent/NO790568L/en unknown
- 1979-02-20 AR AR275559A patent/AR229152A1/en active
- 1979-02-20 LU LU80946A patent/LU80946A1/en unknown
- 1979-02-20 DK DK73379A patent/DK73379A/en unknown
- 1979-02-20 NL NL7901319A patent/NL7901319A/en not_active Application Discontinuation
- 1979-02-20 ES ES477878A patent/ES477878A1/en not_active Expired
- 1979-02-20 SE SE7901510A patent/SE431643B/en not_active IP Right Cessation
- 1979-02-21 PL PL1979213593A patent/PL118158B1/en unknown
- 1979-02-21 DE DE19792906768 patent/DE2906768A1/en not_active Ceased
- 1979-02-21 DD DD79211155A patent/DD141827A5/en unknown
- 1979-02-21 FI FI790593A patent/FI790593A7/en unknown
- 1979-02-21 JP JP2019979A patent/JPS54125656A/en active Granted
- 1979-02-21 RO RO7996682A patent/RO77228A/en unknown
- 1979-02-21 CH CH168679A patent/CH639370A5/en not_active IP Right Cessation
- 1979-02-21 FR FR7904455A patent/FR2417499A1/en active Granted
- 1979-04-23 ES ES479833A patent/ES479833A1/en not_active Expired
- 1979-04-23 ES ES479832A patent/ES479832A1/en not_active Expired
-
1980
- 1980-02-04 SU SU802878653A patent/SU882409A3/en active
- 1980-06-23 AR AR281499A patent/AR228036A1/en active
-
1983
- 1983-10-13 HK HK413/83A patent/HK41383A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| LU80946A1 (en) | 1979-06-18 |
| PL118158B1 (en) | 1981-09-30 |
| DE2906768A1 (en) | 1979-08-23 |
| NL7901319A (en) | 1979-08-23 |
| PH15381A (en) | 1982-12-17 |
| ES479833A1 (en) | 1979-11-16 |
| JPH0134986B2 (en) | 1989-07-21 |
| FR2417499B1 (en) | 1982-06-04 |
| CH639370A5 (en) | 1983-11-15 |
| PT69254A (en) | 1979-03-01 |
| GB2014987A (en) | 1979-09-05 |
| PL213593A1 (en) | 1980-02-25 |
| AR228036A1 (en) | 1983-01-14 |
| IE47971B1 (en) | 1984-08-08 |
| IE790297L (en) | 1979-08-21 |
| FR2417499A1 (en) | 1979-09-14 |
| ES477878A1 (en) | 1980-03-01 |
| GB2014987B (en) | 1982-11-03 |
| DK73379A (en) | 1979-08-22 |
| JPS54125656A (en) | 1979-09-29 |
| NO790568L (en) | 1979-08-22 |
| RO77228A (en) | 1981-08-17 |
| SU882409A3 (en) | 1981-11-15 |
| AR229152A1 (en) | 1983-06-30 |
| HK41383A (en) | 1983-10-21 |
| SE7901510L (en) | 1979-08-22 |
| CS230562B2 (en) | 1984-08-13 |
| IL56662A0 (en) | 1979-05-31 |
| CA1124723A (en) | 1982-06-01 |
| GR82336B (en) | 1984-12-13 |
| FI790593A7 (en) | 1979-08-22 |
| NZ189626A (en) | 1982-03-09 |
| DD141827A5 (en) | 1980-05-21 |
| SE431643B (en) | 1984-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970303 |