ES479928A1 - Un procedimiento para la preparacion de derivados de 6,7-ben-zomorfan. - Google Patents

Un procedimiento para la preparacion de derivados de 6,7-ben-zomorfan.

Info

Publication number
ES479928A1
ES479928A1 ES479928A ES479928A ES479928A1 ES 479928 A1 ES479928 A1 ES 479928A1 ES 479928 A ES479928 A ES 479928A ES 479928 A ES479928 A ES 479928A ES 479928 A1 ES479928 A1 ES 479928A1
Authority
ES
Spain
Prior art keywords
dimethyl
processes
preparation
pharmaceutical compositions
benzomorphan derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479928A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACF Chemiefarma NV
Original Assignee
ACF Chemiefarma NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ACF Chemiefarma NV filed Critical ACF Chemiefarma NV
Publication of ES479928A1 publication Critical patent/ES479928A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Un procedimiento para la preparación de derivados de 6,7-benzomorfán activos o racémicos de fórmula-01 (I): **(Fórmula-01)** en donde A es un enlace directo o -CH2-, R1 es hidrógeno, alquilo C1-3, alquenilo C2-3, alquinilo C2-3, alcoxi C1-2, alquilo C1-2 o cicloalquilo C3-6, R2 es hidrógeno o alquilo C1-3 , o R1 y R2, junto con el átomo de carbono al que están ligadas, forman un grupo cicloalquilo C3-6 o un grupo heterocicloalquilo de 4 a 6 miembros conteniendo un átomo de oxígeno como heteroátomo único, R3 es hidroxi, alcoxi C1-4, alqueniloxi C2-4, o R6COO- en donde R6 es hidrógeno, alquilo C1-3, fenilo o bencilo, R4 es hidrógeno, alquilo C1-4 o fenilo, y R5 es hidrógeno, hidroxi, alcoxi C1-3 o R7COO- en donde R7 es hidrógeno, alquilo C1-3, fenilo, bencilo, fenetilo o 3¿piridilo, o formas de sal de adición de ácido de los mismos, caracterizado porque se alquila un benzomorfán de fórmula-02 (IV): **(Fórmula-02)** en donde R4 y R5 tienen los significados previamente indicados, con un compuesto de fórmula-03 (V): **(Fórmula-03)** en donde A, R1, R2 y R3 tienen los significados previamente indicados, e Y es un grupo nucleofílico que se separa, y porque se convierte facultativamente la forma de base libre en la forma de sal de adición de ácido, preferiblemente en un disolvente orgánico, por ejemplo, entre 0ºC a la temperatura de ebullición.
ES479928A 1978-04-26 1979-04-25 Un procedimiento para la preparacion de derivados de 6,7-ben-zomorfan. Expired ES479928A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7804509A NL7804509A (nl) 1978-04-26 1978-04-26 Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan.

Publications (1)

Publication Number Publication Date
ES479928A1 true ES479928A1 (es) 1980-08-16

Family

ID=19830738

Family Applications (2)

Application Number Title Priority Date Filing Date
ES479928A Expired ES479928A1 (es) 1978-04-26 1979-04-25 Un procedimiento para la preparacion de derivados de 6,7-ben-zomorfan.
ES488134A Expired ES488134A1 (es) 1978-04-26 1980-01-31 Un procedimiento para la preparacion de derivados de 6,7- benzomorfan

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES488134A Expired ES488134A1 (es) 1978-04-26 1980-01-31 Un procedimiento para la preparacion de derivados de 6,7- benzomorfan

Country Status (19)

Country Link
US (1) US4473576A (es)
EP (1) EP0004960B1 (es)
JP (1) JPS54151979A (es)
AT (1) AT373585B (es)
AU (1) AU529456B2 (es)
CA (1) CA1111422A (es)
DE (1) DE2966325D1 (es)
DK (1) DK157979A (es)
ES (2) ES479928A1 (es)
FI (1) FI67372C (es)
HU (1) HU182470B (es)
IE (1) IE48276B1 (es)
IL (1) IL57129A (es)
IT (1) IT1115132B (es)
NL (1) NL7804509A (es)
NZ (1) NZ190278A (es)
PH (1) PH17142A (es)
PT (1) PT69536A (es)
ZA (1) ZA792005B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
ATE314372T1 (de) * 1998-01-29 2006-01-15 Univ Monash Therapeutische verbindungen
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050227A (es) * 1963-11-07
NL132138C (es) * 1966-05-20
US3883536A (en) * 1970-05-27 1975-05-13 Acf Chemiefarma Nv 3,3-Disubstituted-2-benzyl-4-piperidinols
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
DE2233088A1 (de) * 1972-06-30 1974-01-17 Schering Ag Benzomorphanderivate
US4020164A (en) * 1972-06-30 1977-04-26 Schering Aktiengesellschaft Benzomorphan derivatives
DE2315339A1 (de) * 1973-03-28 1974-10-17 Boehringer Sohn Ingelheim N-(heteroarylmethyl)-2'-hydroxy-5.9. 9-trimethyl-benzomorphane, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu ihrer herstellung
US4087532A (en) * 1974-03-09 1978-05-02 Boehringer Ingelheim Gmbh Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
DE2437610A1 (de) * 1974-08-05 1976-02-26 Boehringer Sohn Ingelheim Neue 5,9-beta-disubstituierte 2-tetrahydrofurfuryl-6,7-benzomorphane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung

Also Published As

Publication number Publication date
JPS54151979A (en) 1979-11-29
IL57129A (en) 1983-12-30
IE48276B1 (en) 1984-11-28
IT1115132B (it) 1986-02-03
NL7804509A (nl) 1979-10-30
PH17142A (en) 1984-06-04
FI67372B (fi) 1984-11-30
FI67372C (fi) 1985-03-11
DK157979A (da) 1979-11-23
AU529456B2 (en) 1983-06-09
IL57129A0 (en) 1979-07-25
EP0004960A1 (en) 1979-10-31
AU4633079A (en) 1979-11-01
CA1111422A (en) 1981-10-27
US4473576A (en) 1984-09-25
AT373585B (de) 1984-02-10
NZ190278A (en) 1981-12-15
HU182470B (en) 1984-01-30
ES488134A1 (es) 1980-09-16
FI791239A7 (fi) 1979-10-27
ATA307579A (de) 1983-06-15
IE790838L (en) 1979-10-26
ZA792005B (en) 1980-11-26
IT7948786A0 (it) 1979-04-19
PT69536A (fr) 1979-05-01
EP0004960B1 (en) 1983-10-19
DE2966325D1 (en) 1983-11-24

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