ES481189A1 - Un procedimiento para preparar amonioalchohiltiodinemzotie- pinas. - Google Patents
Un procedimiento para preparar amonioalchohiltiodinemzotie- pinas.Info
- Publication number
- ES481189A1 ES481189A1 ES481189A ES481189A ES481189A1 ES 481189 A1 ES481189 A1 ES 481189A1 ES 481189 A ES481189 A ES 481189A ES 481189 A ES481189 A ES 481189A ES 481189 A1 ES481189 A1 ES 481189A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- alkyl
- aminoalkylthiodibenzthiepines
- pharmaceuticals
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- -1 N-substituted piperazinyl Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/14—[b,f]-condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
1. Un procedimiento para preparar aminoalcohiltiodibenzotiepinas de la fórmula-01 (I): **(Fórmula-01)** en la que X e Y son iguales o diferentes e individualmente pueden ser hidrógeno, halógeno, trifluorometilo, alcoxi de C1 a C6, alcohilo de C1 a C6, alcohiltio de C1 a C6, alcohilsulfonilo de C1 a C6, alcohilsulfinilo de C1 a C6; amino o nitro; Z es N -R1 -R2, donde R1 es alcohilo de C1 a C6 de cadena recta o ramificada, cicloalcohilo-alcohilo de C1 a C6 donde el anillo de cicloalcohilo contiene de 3 a 6 átomos de carbono, alquenilo de C2 a C6 p alquinilo de C2 a C6; R2 es alcohilo de C1-C6 de cadena recta o ramificada; m es el número entero O ó 1; y n es un número entero de 2 a 4; y una sal de adición de ácido fisiológicamente tolerable de las mismas, que comprende hacer reaccionar un compuesto de la fórmula-02 (Ia): **(Fórmula-02)** donde X, Y, m y n son como se han definido en la fórmula I, R1 es hidrógeno yR2 es alcohilo de C1 a C6 de cadena recta o ramificada, con un halogenuro de alcohilo de C1 a C6 de cadena recta o ramificada, halogenuro de alquenilo de C2 a C6, halogenuro de alquinilo de C2 a C6 o halogenuro de cicloalcohilo de C1 a C6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86008277A | 1977-12-13 | 1977-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES481189A1 true ES481189A1 (es) | 1980-09-01 |
Family
ID=25332450
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475769A Expired ES475769A1 (es) | 1977-12-13 | 1978-12-06 | Un procedimiento para preparar aminoalcohiltiodibenztiepinas |
| ES481188A Expired ES481188A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
| ES481187A Expired ES481187A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
| ES481185A Expired ES481185A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
| ES481189A Expired ES481189A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar amonioalchohiltiodinemzotie- pinas. |
| ES481186A Expired ES481186A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES475769A Expired ES475769A1 (es) | 1977-12-13 | 1978-12-06 | Un procedimiento para preparar aminoalcohiltiodibenztiepinas |
| ES481188A Expired ES481188A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
| ES481187A Expired ES481187A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
| ES481185A Expired ES481185A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES481186A Expired ES481186A1 (es) | 1977-12-13 | 1979-06-01 | Un procedimiento para preparar aminoalcohiltiodibenzotiepi- nas. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0002500B1 (es) |
| JP (1) | JPS5498794A (es) |
| AT (1) | AT369740B (es) |
| CA (1) | CA1110625A (es) |
| DE (1) | DE2862219D1 (es) |
| ES (6) | ES475769A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008096755A1 (ja) * | 2007-02-07 | 2008-08-14 | Nippon Suisan Kaisha, Ltd. | バニロイド受容体（ｖｒ１）阻害剤及びその用途 |
-
1978
- 1978-12-06 ES ES475769A patent/ES475769A1/es not_active Expired
- 1978-12-07 EP EP78101593A patent/EP0002500B1/de not_active Expired
- 1978-12-07 DE DE7878101593T patent/DE2862219D1/de not_active Expired
- 1978-12-12 CA CA317,810A patent/CA1110625A/en not_active Expired
- 1978-12-12 AT AT0883878A patent/AT369740B/de not_active IP Right Cessation
- 1978-12-13 JP JP15908878A patent/JPS5498794A/ja active Granted
-
1979
- 1979-06-01 ES ES481188A patent/ES481188A1/es not_active Expired
- 1979-06-01 ES ES481187A patent/ES481187A1/es not_active Expired
- 1979-06-01 ES ES481185A patent/ES481185A1/es not_active Expired
- 1979-06-01 ES ES481189A patent/ES481189A1/es not_active Expired
- 1979-06-01 ES ES481186A patent/ES481186A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATA883878A (de) | 1982-06-15 |
| EP0002500A1 (de) | 1979-06-27 |
| ES481185A1 (es) | 1980-08-16 |
| ES481186A1 (es) | 1980-08-16 |
| ES475769A1 (es) | 1980-01-16 |
| DE2862219D1 (en) | 1983-05-05 |
| JPS633860B2 (es) | 1988-01-26 |
| CA1110625A (en) | 1981-10-13 |
| JPS5498794A (en) | 1979-08-03 |
| AT369740B (de) | 1983-01-25 |
| EP0002500B1 (de) | 1983-03-30 |
| ES481188A1 (es) | 1980-08-16 |
| ES481187A1 (es) | 1980-08-16 |
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