ES483901A1 - Un procedimiento para preparar compuestos de cefem - Google Patents

Un procedimiento para preparar compuestos de cefem

Info

Publication number
ES483901A1
ES483901A1 ES483901A ES483901A ES483901A1 ES 483901 A1 ES483901 A1 ES 483901A1 ES 483901 A ES483901 A ES 483901A ES 483901 A ES483901 A ES 483901A ES 483901 A1 ES483901 A1 ES 483901A1
Authority
ES
Spain
Prior art keywords
alkyl
amino
protected
hydroxy
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES483901A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES483901A1 publication Critical patent/ES483901A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento para preparar compuestos de cefem de fórmula **fórmula** donde R1 es amino o amino protegido, R2 es alcohilo inferior, aminoalcohilo inferior, amino protegido-alcohilo inferior, hidroxialcohilo inferior, hidroxilo protegido-alcohilo inferior, alcohilo inferior-tioalcohilo inferior, carboxialcohilo inferior, carboxilo esterificado-alcohilo inferior, cicloalcohilo C3 a C8, alquenilo inferior o alquinilo inferior, R3 es un grupo heterocíclico sustituido con aminoalcohilo inferior, amino protegido-alcohilo inferior, hidroxialcohilo inferior o tanto amino como alcohilo inferior y R4 es carboxilo o carboxilo protegido, siempre que R3 sea un grupo heterocíclico sustituido con hidroxialcohilo inferior o tanto amino como alcohilo inferior cuando R2 es alcohilo inferior, o sus sales aceptables en farmacia.
ES483901A 1978-09-11 1979-09-05 Un procedimiento para preparar compuestos de cefem Expired ES483901A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB7836399 1978-09-11
GB7908799 1979-03-13
GB7910499 1979-03-26

Publications (1)

Publication Number Publication Date
ES483901A1 true ES483901A1 (es) 1980-10-01

Family

ID=27260589

Family Applications (2)

Application Number Title Priority Date Filing Date
ES483901A Expired ES483901A1 (es) 1978-09-11 1979-09-05 Un procedimiento para preparar compuestos de cefem
ES492032A Expired ES8104308A1 (es) 1978-09-11 1980-05-30 Procedimiento para preparar compuestos de cefem

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES492032A Expired ES8104308A1 (es) 1978-09-11 1980-05-30 Procedimiento para preparar compuestos de cefem

Country Status (8)

Country Link
US (3) US4341775A (es)
CH (1) CH650786A5 (es)
DE (1) DE2936434A1 (es)
ES (2) ES483901A1 (es)
FR (1) FR2435479A1 (es)
IT (1) IT1123120B (es)
NL (1) NL7906780A (es)
SE (1) SE450384B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4431643A (en) * 1976-04-12 1984-02-14 Fujisawa Pharmaceutical Co., Ltd. Syn-isomer of 3-substituted-7-[2-cyclopentyloxyimino-2-(2-aminothiazol-4-yl)-acetamido]-3
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
IL63965A (en) * 1980-10-10 1985-01-31 Sparamedica Ag 7-(2-(2-amino-4-selenazoyl)acetamido)cephalosporin derivatives,and intermediates therefor,their preparation and pharmaceutical compositions containing them
US4618606A (en) * 1982-11-17 1986-10-21 Toyama Chemical Co., Ltd. Antibiotic 7-(thiazolyl)-3-(pyrazinylmethyl) or (pyridazinylmethyl) cephalosporins
FR2546520B1 (fr) * 1983-05-27 1985-08-30 Sanofi Sa Nouveaux composes antibiotiques derives des cephalosporines
GB8401093D0 (en) * 1984-01-16 1984-02-15 Fujisawa Pharmaceutical Co Cephem compounds
GB8504072D0 (en) * 1985-02-18 1985-03-20 Fujisawa Pharmaceutical Co Cephem compounds
AU1630988A (en) * 1987-05-30 1988-12-01 Kyoto Pharmaceutical Industries, Ltd. Cephalosporin compound and pharmaceutical composition thereof
US5223496A (en) * 1987-11-10 1993-06-29 The Upjohn Company Cephalosporin antibiotics
WO1989004313A1 (en) * 1987-11-10 1989-05-18 The Upjohn Company Cephalosporin antibiotics
KR100449775B1 (ko) * 1995-11-28 2005-08-17 동아제약주식회사 신규세팔로스포린유도체및그중간체
GB0010475D0 (en) * 2000-04-28 2000-06-14 Biochemie Gmbh Organic compounds
TWI335332B (en) * 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
TWI325323B (en) * 2002-05-24 2010-06-01 Theravance Inc Cross-linked glycopeptide-cephalosporin antibiotics
JP2007500222A (ja) 2003-05-23 2007-01-11 セラヴァンス インコーポレーテッド 架橋グリコペプチド−セファロスポリン抗生物質
DE602004012269T2 (de) * 2003-07-11 2009-04-30 Theravance, Inc., South San Francisco Quervernetzte glycopeptid-cephalosporin-antibiotika
EP2970164B1 (en) 2013-03-13 2017-05-03 Theravance Biopharma Antibiotics IP, LLC Crystalline form of a substituted thiazolylacetic acid triethylamine salt

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
BE845338A (fr) * 1975-09-02 1977-02-21 Nouvelles cephalosporines, procede pour leur obtention et application pharmaceutique
US4202893A (en) * 1976-03-25 1980-05-13 Roussel Uclaf Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
DE2760484C2 (es) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
FR2381053A1 (fr) * 1977-02-18 1978-09-15 Roussel Uclaf Nouvelles oximes derivees de l'acide 3-thiadiazolyl thiomethyl 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung
JPS609719B2 (ja) * 1977-08-06 1985-03-12 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
SE7901262L (sv) * 1978-02-15 1979-08-16 Fujisawa Pharmaceutical Co 3,7-disubstituerade 3-cefem-4-karboxylsyraforeningar och forfarande for deras framstellning
US4220761A (en) * 1978-09-12 1980-09-02 Fujisawa Pharmaceutical Co., Ltd. 7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives

Also Published As

Publication number Publication date
SE450384B (sv) 1987-06-22
US4341775A (en) 1982-07-27
IT7925621A0 (it) 1979-09-11
ES492032A0 (es) 1981-04-01
NL7906780A (nl) 1980-03-13
FR2435479A1 (fr) 1980-04-04
US4487767A (en) 1984-12-11
ES8104308A1 (es) 1981-04-01
SE7907502L (sv) 1980-04-01
DE2936434A1 (de) 1980-03-20
IT1123120B (it) 1986-04-30
FR2435479B1 (es) 1983-05-13
CH650786A5 (de) 1985-08-15
US4366153A (en) 1982-12-28

Similar Documents

Publication Publication Date Title
ES483901A1 (es) Un procedimiento para preparar compuestos de cefem
MY131501A (en) Process for the prepration of clavulanic acid
ES2070660A1 (es) Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
CA2093219A1 (en) Amides of antibiotic ge 2270 factors
ES8704955A1 (es) Un proceso para la produccion de un compuesto de cefalospo- rina
ES461084A1 (es) Un procedimiento para la preparacion del acido n-acilhidro- xiaminohidro carbofosfonico.
IE780515L (en) Morphine derivatives
YU54189A (en) Process for obtaining cephem derivatives and midproducts for the same
JO1704B1 (en) New potent compounds
JPS5777689A (en) Novel cephen compound, or its salt, its preparation, and preventive it as active ingredient
PT991651E (pt) Intermediarios de carbapenem estabilizados e uso sintetico
CA1272726C (en) 2-oxo-1-(aminocarbonylaminosulfonyl- aminocarbonyl)azetidines
EP0192783A4 (en) 2-PIPERAZINOPYRIMIDINE DERIVATIVES AND THEIR PREPARATION PROCESS.
ES8202020A1 (es) Un procedimiento para la preparacion de un compuesto de ce- falosporina
FI915245A0 (fi) 7-acyl-3-(substitueradkarbamoyloxi) cefemfoereningar samt foerfarande foer framstaellning av dessa.
ES8301928A1 (es) Un procedimiento para preparar 4-(2-4-dicloro-3-metilbenzoil)-1,3-dimetil-5-fenaciloxipirazol).
ES8200119A1 (es) Un procedimiento para la preparacion de un derivado de 2-de soxi-fortimicina a o b2-sustituidos.
IE780514L (en) Morphine derivatives
MY103393A (en) 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof
MY103910A (en) 4-oxo-3-quinolinecarboxylic acids useful as antibacterial agents and preparation thereof
IE56917B1 (en) N-sulphenylated hydantoins,a process for their preparation and their use as microbicides
ES8800916A1 (es) Un procedimiento para preparar acidos beta-lactamo-hidroxamicos sulfatados en o
IE820238L (en) Carbapenem derivatives
ES476273A1 (es) Un procedimiento para preparar nuevos analogos de cefalospo-rina
MX9500251A (es) Derivado de indano, procedimiento para prepararlo.