ES485830A1 - Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico. - Google Patents

Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico.

Info

Publication number
ES485830A1
ES485830A1 ES485830A ES485830A ES485830A1 ES 485830 A1 ES485830 A1 ES 485830A1 ES 485830 A ES485830 A ES 485830A ES 485830 A ES485830 A ES 485830A ES 485830 A1 ES485830 A1 ES 485830A1
Authority
ES
Spain
Prior art keywords
selectively
aminoglycosidic antibiotic
acylated
antibiotic
derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485830A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13840278A external-priority patent/JPS5564598A/ja
Priority claimed from JP7306479A external-priority patent/JPS55164696A/ja
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES485830A1 publication Critical patent/ES485830A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

Proceso para la producción de un derivado selectivamente acilado, N-protegido de un antibiótico aminogliosídico, comprendiendo este antibiótico aminoglicosídico una mitad desoxiestreptamina que tienen un grupo 3- aminoglicosilo o 3-alquilaminoglicosilo enlazado con el grupo 6-hidroxi de la mitad desoxiestreptamina, y teniendo el derivado selectivamente acilado, N-protegido algunos de sus grupos amino selectivamente protegidos con un grupo acilo, que comprende los pasos consistentes en: (a) hacer reaccionar un reactivo de acilación que tiene un grupo acilo a introducir como el grupo amino-protector , con un complejo de antibiótico aminoglicosídico-cationes de zinc que ha sido formado por reacción del antibiótico aminoglicosídico con una sal de zinc en un disolvente orgánico inerte, para producir un complejo de cationes de zinc con el derivado selectivamente N-acilado del antibiótico aminoglicosídico que tiene acilados los grupos amino inicialmente no acomplejados, y (b) hacer reaccionar al complejo de cationes de zinc con el derivado selectivamente N-acilado del antibiótico aminoglicosídico, con un reactivo que retire los cationes de zinc de dicho complejo, para producir el deseado derivado selectivamente acilado, N-protegido del antibiótico aminoglicosídico.
ES485830A 1978-11-11 1979-11-08 Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico. Expired ES485830A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13840278A JPS5564598A (en) 1978-11-11 1978-11-11 Preparation of aminoglycoside antibiotic having selectively protected amino group
JP7306479A JPS55164696A (en) 1979-06-12 1979-06-12 Preparation of protected derivative of aminoglycoside antibiotic substance wherein amino groups other than 1-position are selectively protected, and preparation of 1-n- alpha-hydroxy-omega-aminoalkanoyl -aminoglycoside antibiotic substance

Publications (1)

Publication Number Publication Date
ES485830A1 true ES485830A1 (es) 1980-10-01

Family

ID=26414188

Family Applications (2)

Application Number Title Priority Date Filing Date
ES485830A Expired ES485830A1 (es) 1978-11-11 1979-11-08 Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico.
ES492479A Expired ES8105747A1 (es) 1978-11-11 1980-06-16 Proceso para la produccion de un derivado n-acilado, selec- tivamente protegido, de un antibiotico aminoglicosidico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES492479A Expired ES8105747A1 (es) 1978-11-11 1980-06-16 Proceso para la produccion de un derivado n-acilado, selec- tivamente protegido, de un antibiotico aminoglicosidico

Country Status (20)

Country Link
US (1) US4297485A (es)
AR (1) AR241915A1 (es)
AT (1) AT367066B (es)
AU (1) AU529682B2 (es)
CA (1) CA1118416A (es)
CH (2) CH650005A5 (es)
DE (2) DE2953878C2 (es)
DK (1) DK476679A (es)
ES (2) ES485830A1 (es)
FR (2) FR2441631A1 (es)
GB (2) GB2036020B (es)
IE (1) IE48972B1 (es)
IN (1) IN151454B (es)
IT (1) IT1166021B (es)
LU (1) LU81881A1 (es)
MX (1) MX6181E (es)
NL (1) NL7907892A (es)
PH (2) PH16263A (es)
SE (2) SE446632B (es)
YU (1) YU44185B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55105699A (en) * 1979-02-05 1980-08-13 Microbial Chem Res Found 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative
US4424344A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4468512A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
US4424345A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
US4833232A (en) * 1986-05-02 1989-05-23 Exxon Research And Engineering Company Synthesis of novel highly intrinsic conducting organic polymers
US5442047A (en) * 1991-12-04 1995-08-15 Schering Corporation Process for preparing isepamicin
EP0547031B1 (en) * 1989-06-21 1997-04-23 Schering Corporation N-protected-(S)-isoserine compounds
IT1237490B (it) * 1989-09-22 1993-06-07 Chementecno S R L Monza Milano Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
EP0446670B1 (en) * 1990-03-08 1994-09-21 Biochimica Opos Spa Method of preparation of amikacin precursors
US5488038A (en) 1992-11-27 1996-01-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Dibekacin derivatives and arbekacin derivatives active against resistant bacteria
KR0139021B1 (ko) * 1995-02-09 1998-04-30 김은영 1-엔(n)-에틸시소마이신의 제조방법
KR100927626B1 (ko) * 2002-09-18 2009-11-20 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 이세파마이신의 제조 방법
KR100467506B1 (ko) * 2002-10-01 2005-01-24 경동제약 주식회사 이세파마이신의 제조방법
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
US8791245B2 (en) * 2008-10-03 2014-07-29 Glycan Bioscience LLC Anionic conjugates of glycosylated bacterial metabolite
CN101928310B (zh) * 2010-03-26 2012-09-05 常州方圆制药有限公司 3,2’,6’-三-N-乙酰基庆大霉素C1a的制备方法
CN102250166A (zh) * 2010-05-21 2011-11-23 江西济民可信集团有限公司 一种依替米星硫酸盐的制备方法
CN102746349B (zh) * 2012-06-27 2014-07-30 常州方圆制药有限公司 一种硫酸依替米星中间体3，2’，6’-三-N-乙酰基庆大霉素Cla的合成方法
CN111138505B (zh) * 2020-02-17 2021-10-08 山东安信制药有限公司 一种阿米卡星的制备方法
CN116333011B (zh) * 2023-03-31 2025-11-11 江西师范大学 一种全脱乙酰化壳寡糖及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI52847C (fi) * 1971-09-15 1977-12-12 Suomen Sokeri Oy Menetelmä ainakin kaksi hydroksyyliryhmää sisältävien yhdisteiden alky yli-, alkenyyli- tai asyylijohdannaisten valmistamiseksi
US3781268A (en) * 1972-01-27 1973-12-25 Bristol Myers Co Antibiotic derivatives of kanamycin
GB1402427A (en) * 1972-05-03 1975-08-06 Ranks Hovis Mcdougall Ltd Antibiotics
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
US4107424A (en) * 1972-10-06 1978-08-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics
JPS5324415B2 (es) * 1972-10-06 1978-07-20
GB1441202A (en) * 1973-05-15 1976-06-30 Microbial Chem Res Found 1-n-isoserylkanamycins and the production thereof
JPS554118B2 (es) * 1973-08-29 1980-01-29
JPS5635195B2 (es) * 1974-01-24 1981-08-15
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby

Also Published As

Publication number Publication date
MX6181E (es) 1984-12-07
IT1166021B (it) 1987-04-29
GB2065123A (en) 1981-06-24
AT367066B (de) 1982-05-25
FR2441631B1 (es) 1982-02-19
SE463264B (sv) 1990-10-29
FR2441631A1 (fr) 1980-06-13
US4297485A (en) 1981-10-27
FR2482109B1 (es) 1983-10-14
ATA707979A (de) 1981-10-15
GB2036020B (en) 1983-01-06
AU529682B2 (en) 1983-06-16
DE2953878C2 (de) 1984-05-24
FR2482109A1 (fr) 1981-11-13
NL7907892A (nl) 1980-05-13
IE792026L (en) 1980-05-11
PH16263A (en) 1983-08-23
DE2945010A1 (de) 1980-05-22
AR241915A1 (es) 1993-01-29
SE8406344L (sv) 1984-12-13
YU44185B (en) 1990-04-30
SE7908850L (sv) 1980-05-12
SE8406344D0 (sv) 1984-12-13
IN151454B (es) 1983-04-23
DK476679A (da) 1980-05-12
GB2065123B (en) 1982-12-22
IT7909592A0 (it) 1979-11-12
YU274379A (en) 1983-02-28
LU81881A1 (fr) 1980-01-25
DE2945010C2 (de) 1984-02-23
CH650004A5 (de) 1985-06-28
CH650005A5 (de) 1985-06-28
SE446632B (sv) 1986-09-29
CA1118416A (en) 1982-02-16
ES492479A0 (es) 1981-06-01
GB2036020A (en) 1980-06-25
PH15906A (en) 1983-04-15
ES8105747A1 (es) 1981-06-01
IE48972B1 (en) 1985-06-26
AU5262279A (en) 1980-05-15

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