ES485916A1 - 2:Amino 4:picoline thio:salicylate - is a topical analgesic and antiinflammatory - Google Patents

2:Amino 4:picoline thio:salicylate - is a topical analgesic and antiinflammatory

Info

Publication number
ES485916A1
ES485916A1 ES485916A ES485916A ES485916A1 ES 485916 A1 ES485916 A1 ES 485916A1 ES 485916 A ES485916 A ES 485916A ES 485916 A ES485916 A ES 485916A ES 485916 A1 ES485916 A1 ES 485916A1
Authority
ES
Spain
Prior art keywords
picoline
amino
antiinflammatory
salicylate
thio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485916A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Especialidades Latinas Medicamentos Universales SA
Original Assignee
Especialidades Latinas Medicamentos Universales SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Especialidades Latinas Medicamentos Universales SA filed Critical Especialidades Latinas Medicamentos Universales SA
Priority to ES485916A priority Critical patent/ES485916A1/en
Publication of ES485916A1 publication Critical patent/ES485916A1/en
Priority to PT71876A priority patent/PT71876B/en
Priority to CA363,443A priority patent/CA1126277A/en
Priority to BE0/202689A priority patent/BE886013A/en
Priority to DE19803041815 priority patent/DE3041815A1/en
Priority to BR8007281A priority patent/BR8007281A/en
Priority to GR63329A priority patent/GR72538B/el
Priority to IT50139/80A priority patent/IT1147024B/en
Priority to FR8024155A priority patent/FR2485009A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

2-Amino-4-picoline thiosalicylate (I) is a new topical analgesic and antiinflammatory. (I) is prepd. by reaction of thiosalicyclic acid with 2-amino-4-picoline and may be formulated as a cream, ointment, solution, lotion, spray or gel contg. 5-20% (I). Oral LD50 is 350 mg per kg (rat) or 265 mg per kg (mouse). Intraperitoneal LD50 is 75 mg per kg (rat and 100 mg per kg (mouse).
ES485916A 1979-11-13 1979-11-13 2:Amino 4:picoline thio:salicylate - is a topical analgesic and antiinflammatory Expired ES485916A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
ES485916A ES485916A1 (en) 1979-11-13 1979-11-13 2:Amino 4:picoline thio:salicylate - is a topical analgesic and antiinflammatory
PT71876A PT71876B (en) 1979-11-13 1980-10-06 Process for the preparation of thiossalicilate of 2-amino-4-picoline
CA363,443A CA1126277A (en) 1979-11-13 1980-10-28 Production of novel compound
BE0/202689A BE886013A (en) 1979-11-13 1980-11-03 2-AMINO-4-PICOLIN THIOSALICYLATE, ITS PREPARATION AND ITS USE
DE19803041815 DE3041815A1 (en) 1979-11-13 1980-11-06 2-AMINO-4-PICOLINTHIOSALICYLATE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCT CONTAINING THE SAME
BR8007281A BR8007281A (en) 1979-11-13 1980-11-07 PROCESS OF OBTAINING THOSALICILLATE FROM 2-AMINO-4-PICOLINE
GR63329A GR72538B (en) 1979-11-13 1980-11-11
IT50139/80A IT1147024B (en) 1979-11-13 1980-11-12 PROCEDURE FOR THE PREPARATION OF 2-AMINO-4-PICOLIN TIOSA-LICILATE AND PRODUCT OBTAINED
FR8024155A FR2485009A1 (en) 1979-11-13 1980-11-13 2:Amino 4:picoline thio:salicylate - is a topical analgesic and antiinflammatory

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES485916A ES485916A1 (en) 1979-11-13 1979-11-13 2:Amino 4:picoline thio:salicylate - is a topical analgesic and antiinflammatory

Publications (1)

Publication Number Publication Date
ES485916A1 true ES485916A1 (en) 1980-08-01

Family

ID=8479285

Family Applications (1)

Application Number Title Priority Date Filing Date
ES485916A Expired ES485916A1 (en) 1979-11-13 1979-11-13 2:Amino 4:picoline thio:salicylate - is a topical analgesic and antiinflammatory

Country Status (9)

Country Link
BE (1) BE886013A (en)
BR (1) BR8007281A (en)
CA (1) CA1126277A (en)
DE (1) DE3041815A1 (en)
ES (1) ES485916A1 (en)
FR (1) FR2485009A1 (en)
GR (1) GR72538B (en)
IT (1) IT1147024B (en)
PT (1) PT71876B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2085646A1 (en) * 1970-04-22 1971-12-31 Rabot Ets David Salicylates of aminopyridines - with analgesic and antiinflammatory activity

Also Published As

Publication number Publication date
DE3041815A1 (en) 1981-09-03
BR8007281A (en) 1981-05-19
FR2485009A1 (en) 1981-12-24
PT71876A (en) 1980-11-01
CA1126277A (en) 1982-06-22
PT71876B (en) 1981-08-31
IT8050139A0 (en) 1980-11-12
BE886013A (en) 1981-03-02
IT1147024B (en) 1986-11-19
GR72538B (en) 1983-11-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000209