ES486156A1 - Procedimiento para la obtencion de esteres de acidos glico- licos - Google Patents

Procedimiento para la obtencion de esteres de acidos glico- licos

Info

Publication number
ES486156A1
ES486156A1 ES486156A ES486156A ES486156A1 ES 486156 A1 ES486156 A1 ES 486156A1 ES 486156 A ES486156 A ES 486156A ES 486156 A ES486156 A ES 486156A ES 486156 A1 ES486156 A1 ES 486156A1
Authority
ES
Spain
Prior art keywords
formula
azoniaspiro
derivatives
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES486156A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syntex USA LLC
Original Assignee
Syntex USA LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex USA LLC filed Critical Syntex USA LLC
Publication of ES486156A1 publication Critical patent/ES486156A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento para la obtención de ésteres de ácidos glicolicos, que sirven como broncodilatadores anticolinérgicos, caracterizado porque comprende hacer reaccionar un compuesto representado por la fórmula **(formula)** con un compuesto de la formula x(ch2)nx en que R1 y R2 son iguales o diferentes y son alcohilo C1 a C6, cicloalcohilo C5 o C6, cicloalquenilo C5 o C6, fenilo opcionalmente sustituido con un sustituyente seleccionado del grupo alcohilo C1 a C6, alcoxi C1 a C6 y halo, arilo heterocíclico C4 o C5, siendo el heteroátomo oxigeno, nitrógeno o azufre; n es el número entero 4 ó 5; y X es un anión farmaceúticamente aceptable, preferentemente nitrato, metanosulfonato, bencenosulfonato, para - toluenosulfonato, cloruro, bromuro o yoduro.
ES486156A 1978-11-24 1979-11-20 Procedimiento para la obtencion de esteres de acidos glico- licos Expired ES486156A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/963,258 US4208423A (en) 1978-11-24 1978-11-24 Anticholinergic bronchodilators

Publications (1)

Publication Number Publication Date
ES486156A1 true ES486156A1 (es) 1980-09-16

Family

ID=25506985

Family Applications (1)

Application Number Title Priority Date Filing Date
ES486156A Expired ES486156A1 (es) 1978-11-24 1979-11-20 Procedimiento para la obtencion de esteres de acidos glico- licos

Country Status (6)

Country Link
US (1) US4208423A (es)
EP (1) EP0012071A1 (es)
JP (1) JPS55105684A (es)
AU (1) AU5310279A (es)
ES (1) ES486156A1 (es)
ZA (1) ZA796220B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5025099A (en) * 1990-02-02 1991-06-18 American Cyanamid Company (3-amino-1-propynyl)methylthiothiophene derivatives
JP4057088B2 (ja) * 1996-04-22 2008-03-05 株式会社カネカ ピロリジン誘導体の製造方法
SI0937041T1 (en) * 1996-11-11 2003-10-31 Christian R. Noe Use of a pharmaceutically acceptable salt of (3R,2'R)-3-((Cyclopently-hydroxyphenylacetyl)oxy)-1,1-dimethyl-pyrrolidinium for the preparation of a medicament
US6613795B2 (en) 1996-11-11 2003-09-02 Christian Noe Enantiomerically pure basic arylcycloalkylhydroxycarboxylic esters, processes for their preparation and their use in medicaments
AU2002303425A1 (en) * 2001-04-24 2002-11-05 Epigenesis Pharmaceuticals, Inc. Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent
WO2004056767A1 (en) * 2002-12-23 2004-07-08 Ranbaxy Laboratories Limited 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US20050101545A1 (en) * 2003-07-31 2005-05-12 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
US20090317476A1 (en) * 2003-07-31 2009-12-24 Robinson Cynthia B Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
EP1781607A2 (en) * 2004-08-19 2007-05-09 Ranbaxy Laboratories Limited Pyrrolidine derivatives as muscarinic receptor antagonists
CN103254120B (zh) * 2013-05-16 2015-05-27 中国科学院化学研究所 一种螺环氮杂糖季铵盐化合物及其制备方法与应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2812334A (en) * 1956-02-10 1957-11-05 Upjohn Co Organic compounds
US3318902A (en) * 1963-07-10 1967-05-09 American Home Prod Substituted phenylacetic acid esters of hydroxyalkyl azaspiranes
IL22666A (en) * 1964-01-06 1968-10-24 Robins Co Inc A H Compositions for inhibiting perspiration containing an 1,1-dialkyl-3-hydroxy-pyrrolidinium ester of an alpha-phenyl-alpha-cycloalkyl-clycolic or acetic acid
FR2142809A1 (en) * 1971-06-25 1973-02-02 Delalande Sa 3-hydroxy-3-methyl-2-methylene pyrrolidinium iodides - with vasodilator, hypotensive and analgesic activity

Also Published As

Publication number Publication date
ZA796220B (en) 1981-06-24
US4208423A (en) 1980-06-17
EP0012071A1 (en) 1980-06-11
JPS55105684A (en) 1980-08-13
AU5310279A (en) 1980-06-12

Similar Documents

Publication Publication Date Title
ES483767A1 (es) Procedimiento para producir n-arilsulfonil-l-argininamidas
DK458781A (da) Substitueret 1-cardethiapen-2-em-3-carboxylsyre og fremgangsmaade til fremstilling deraf
IE810315L (en) Indane derivatives
ES8104990A1 (es) Un procedimiento para preparar derivados n-acilicos de compuestos aminicos heterociclicos.
ES250753A1 (es) Procedimiento para la obtencion de los anhidridos y amidas de acido graso 0, 0-dialquilditiofosforilico utilizables como materias activas para los insecticidas
GB900805A (en) Improvements in or relating to fungicides having 1,2-dithiole nucleus
ES391633A1 (es) Un procedimiento para la preparacion de una 2,2-diaril-4- piperidinobutiramida.
ES483152A1 (es) Procedimiento para preparar derivados de feniliminometil-pi-ridina
US2507337A (en) 1, 5-dialkyl tetrazoles and preparation thereof
ES436883A1 (es) Procedimiento de preparacion de nuevos derivados de alcano- lamina y de sus isomeros opticos.
US2329884A (en) Method of preventing growth of fungi
ES437790A1 (es) Procedimiento para preparar composiciones farmaceuticas y veterinarias.
SE7513126L (sv) Nya kvevehaltiga, polycykliska foreningar jemte sett for deras framstellning
MX20200A (es) Proceso para la preparacion de derivados insaturados del acido aminodicarboxilico producto obtenido y composicion farmaceutica que lo incluye.
US2329883A (en) Mercuri-acetylide compound and method of preparing the same
ES388822A1 (es) Procedimiento para la obtencion de compuestos biocidas.
ES393554A1 (es) Un procedimiento para la preparacion de derivados de tia- zol.
GB1085340A (en) New phosphoric and thiophosphoric acid ester derivatives
GB948522A (en) Pyrazinylphosphoroamidothioates and method for preparing the same
ES450028A1 (es) Un procedimiento de preparacion de n1nl(-)-2-hidroxi-4-ami- no-butiroiln4-0n2', 6'-diamino-2', 6'-disesoxi-alfa, d-glu- copirano-siln6-0n3"-metilamino-3", 4",6"-tridesoxi-alfa-d- xilohexopiranosiln2-desoxi-estrepamina.
GB975924A (en) N-heterocyclic 2,6-dialkylbenzoic acid esters
GB1104683A (en) Di(thiocarbamoyl)-monosulphide derivatives and pesticidal compositions containing same
GB1055535A (en) Method for protecting plants against fungi and composition for use therein
GB1012313A (en) Improvements in or relating to thieno-benzothiapyran derivatives
GB805511A (en) 1,1-diaryl-2-aminoalkanols