ES496256A1 - Procedimiento para la preparacion de piridinas sustituidas - Google Patents

Procedimiento para la preparacion de piridinas sustituidas

Info

Publication number
ES496256A1
ES496256A1 ES496256A ES496256A ES496256A1 ES 496256 A1 ES496256 A1 ES 496256A1 ES 496256 A ES496256 A ES 496256A ES 496256 A ES496256 A ES 496256A ES 496256 A1 ES496256 A1 ES 496256A1
Authority
ES
Spain
Prior art keywords
pyridine derivatives
atoms
processes
preparation
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496256A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES496256A1 publication Critical patent/ES496256A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de piridinas sustituidas de la fórmula (I) **fórmula** en donde R1 significa hidrógeno, alcohilo con hasta 6 átomos de carbono y aralcohilo con 7-9 átomos de carbono; R2 significa hidrógeno y alcanoílo con 2 hasta 7 átomos de carbono; y R3 significa alcohilo con hasta 6 átomos de carbono, así como sus sales por adición, caracterizado porque, a) se hace reaccionar un hidroxiéster de la fórmula general II **fórmula** en donde R1 significa alcohilo con hasta 6 átomos de carbono y aralcohilo con 7-9 átomos de carbono, con un epóxido de la fórmula III **fórmula** en donde X significa un átomo de halógeno, preferiblemente cloro, y a continuación se hace reaccionar con una alcohilamina primaria con hasta 6 átomos de carbono; o b) se hace reaccionar un hidroxiéster de la fórmula general II con un derivado de azetidina de la fórmula IV **fórmula** en donde R4 representa un radical alcohilo con hasta 6 átomos de carbono; o c) se hace reaccionar un hidroxiéster de lafórmula general Ii con una oxazolidina de la fórmula V **fórmula** en donde R3 tiene el significado en la fórmula I y R5 representa un radical acohilo o un radical arilo con hasta 6 átomos de carbono, preferiblemente el grupo fenilo, e Y representa tosiloxi o mesiloxi, y a continuación se trata con un ácido inorgánico diluido , o d) se hace reaccionar un compuesto de la fórmula general VI **fórmula** en donde R1 tiene el significado indicado en la fórmula II, con un epóxido de la fórmula general VII **fórmula** en donde M representa un metal alcalino , preferiblemente sodio o potasio, y a continuación se hace reaccionar con una alcohilamina primaria con hasta 6 átomos de carbono; o e) se hace reaccionar un compuesto de la fórmula general VI con una oxazolidina de la fórmula VIII **fórmula** en donde M, R3 y R5 tienen los significados arriba indicados y a continuación se trata con un ácido inorgánico diluido y eventualmente se hidrolizan, en condiciones ácidas o alcalinas, compuestos de la fórmula I en los cuales R1 significa alcohilo o aralcohilo, y se transformar en la correspondiente sal por adición de ácido o sal de metal alcalino o alcalino-térreo, y eventualmente compuestos de la fórmula I, en los cuales R2 es hidrógeno, son acilados con un derivado de ácido capaz de reaccionar, preferiblemente el cloruro de ácido o anhídrido de ácido, en presencia de un catalizador de esterificación.
ES496256A 1979-10-26 1980-10-24 Procedimiento para la preparacion de piridinas sustituidas Expired ES496256A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19792943774 DE2943774A1 (de) 1979-10-26 1979-10-26 Substituierte pyridine, verfahren zu ihrer herstellung und ihre verwendung

Publications (1)

Publication Number Publication Date
ES496256A1 true ES496256A1 (es) 1981-10-01

Family

ID=6084721

Family Applications (1)

Application Number Title Priority Date Filing Date
ES496256A Expired ES496256A1 (es) 1979-10-26 1980-10-24 Procedimiento para la preparacion de piridinas sustituidas

Country Status (8)

Country Link
EP (1) EP0027990A1 (es)
JP (1) JPS5681564A (es)
AU (1) AU6372180A (es)
DD (1) DD153687A5 (es)
DE (1) DE2943774A1 (es)
DK (1) DK422880A (es)
ES (1) ES496256A1 (es)
IL (1) IL61331A0 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207133A1 (es) * 1973-02-20 1976-09-15 Ciba Geigy Ag Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
US4000282A (en) * 1974-12-16 1976-12-28 Merck & Co., Inc. 2-(3-tert. butyl or isopropylamino-2-hydroxypropoxy)-3-cyanopyridines
US4092419A (en) * 1976-06-15 1978-05-30 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
US4053605A (en) * 1976-06-15 1977-10-11 Merck & Co., Inc. Esterified-2(3-lower-alkyl-amino-propoxy)-3-cyano-pyridines and derivatives
US4091104A (en) * 1976-06-15 1978-05-23 Merck & Co., Inc. Substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines, their preparation and use
JPS54106476A (en) * 1978-01-04 1979-08-21 Merck & Co Inc Multiisubstituted 22*33lower alkylaminoo22 r100propoxy*pyridine

Also Published As

Publication number Publication date
IL61331A0 (en) 1980-12-31
DK422880A (da) 1981-04-27
DD153687A5 (de) 1982-01-27
AU6372180A (en) 1981-04-30
JPS5681564A (en) 1981-07-03
EP0027990A1 (de) 1981-05-06
DE2943774A1 (de) 1981-05-14

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