ES509535A0 - "un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina". - Google Patents

"un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina".

Info

Publication number: ES509535A0
Authority: ES; Spain
Prior art keywords: sub; alkyl; hydrogen; aryloxy; tetrahydroisokinolein
Prior art date: 1981-02-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES509535A

Other languages

English (en)

Other versions

ES8305336A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharmaceuticals Inc

Original Assignee

Hoechst Roussel Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-02-19

Filing date

1982-02-12

Publication date

1983-04-01

1982-02-12 Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc

1983-04-01 Publication of ES8305336A1 publication Critical patent/ES8305336A1/es

1983-04-01 Publication of ES509535A0 publication Critical patent/ES509535A0/es

Status Granted legal-status Critical Current

Links

125000000217 alkyl group Chemical group 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
125000003545 alkoxy group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
-1 cyano, benzoyl Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ES509535A 1981-02-19 1982-02-12 "un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina". Granted ES509535A0 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/235,801 US4375471A (en)	1981-02-19	1981-02-19	4-Aryloxy-1,2,3,4-tetrahydroisoquinolines

Publications (2)

Publication Number	Publication Date
ES8305336A1 ES8305336A1 (es)	1983-04-01
ES509535A0 true ES509535A0 (es)	1983-04-01

Family

ID=22886966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES509535A Granted ES509535A0 (es)	1981-02-19	1982-02-12	"un metodo de preparar una 4-ariloxi-1,2,3,4-tetrahidroisoquinoleina".

Country Status (7)

Country	Link
US (1)	US4375471A (es)
EP (1)	EP0058932B1 (es)
JP (1)	JPS57163368A (es)
AT (1)	ATE14308T1 (es)
CA (1)	CA1173833A (es)
DE (1)	DE3264708D1 (es)
ES (1)	ES509535A0 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2564461B1 (fr) *	1984-05-15	1986-09-19	Synthelabo	Derives d'isoquinoleine, leur preparation et leurs applications
DE3640641A1 (de) *	1986-11-28	1988-07-14	Thomae Gmbh Dr K	Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
RO117377B1 (ro) *	1993-06-22	2002-02-28	Boots Co Plc	Derivati de tetrahidroizochinolina, procedeu de preparare, compozitie farmaceutica care ii contine si metoda de tratament
JP2004511465A (ja)	2000-10-10	2004-04-15	カリックス　セラピューティックス　インコーポレイテッド	三環式化合物およびその使用
WO2004050630A1 (en) *	2002-12-02	2004-06-17	Pharmacia & Upjohn Company Llc	The use of aryl- and heteroaryl-substituted tetrahydroisoquinolines in the treatment of chronic and neuropathic pain, migraine headaches, and urge, stress and mixed urinary incontinence
AU2003280192A1 (en) *	2002-12-02	2004-06-23	Pharmacia & Upjohn Company Llc	The use of 4-phenyl substituted tetrahydroisoquinolines in the treatment of pain, migraine and urinary incontinence
BR0316919A (pt) *	2002-12-02	2005-10-18	Pharmacia & Upjohn Co Llc	Utilização de tetraidroisoquinolinas 4-fenil-substituìdas no tratamento da dor, cefaléias da enxaqueca e incontinência urinária

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1035777A (en) *	1963-08-20	1966-07-13	Bellon Labor Sa Roger	Isoquinoline derivatives
NL6504208A (es) *	1964-04-03	1965-10-04
DE1670694B2 (de) *	1966-05-05	1976-07-22	Hoechst Ag, 6000 Frankfurt	Verfahren zur herstellung von tetrahydroisochinolinen
US3629265A (en) *	1969-10-30	1971-12-21	Hoffmann La Roche	7-halo-4-isoquinolones
US4059586A (en) *	1974-03-28	1977-11-22	Marion Laboratories, Inc.	5-Alkoxy-2-alkyl-1,2,3,4-tetrahydroisoquinolene-8-carboxaldehyde and derivatives
GB1504424A (en) *	1975-08-09	1978-03-22	Beecham Group Ltd	Isoquinoline-derived aminoethers

1981
- 1981-02-19 US US06/235,801 patent/US4375471A/en not_active Expired - Fee Related
1982
- 1982-02-12 ES ES509535A patent/ES509535A0/es active Granted
- 1982-02-17 AT AT82101170T patent/ATE14308T1/de not_active IP Right Cessation
- 1982-02-17 DE DE8282101170T patent/DE3264708D1/de not_active Expired
- 1982-02-17 EP EP82101170A patent/EP0058932B1/en not_active Expired
- 1982-02-18 CA CA000396564A patent/CA1173833A/en not_active Expired
- 1982-02-18 JP JP57023690A patent/JPS57163368A/ja active Pending

Also Published As

Publication number	Publication date
CA1173833A (en)	1984-09-04
EP0058932A3 (en)	1982-10-27
DE3264708D1 (en)	1985-08-22
EP0058932B1 (en)	1985-07-17
ES8305336A1 (es)	1983-04-01
ATE14308T1 (de)	1985-08-15
EP0058932A2 (en)	1982-09-01
US4375471A (en)	1983-03-01
JPS57163368A (en)	1982-10-07

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