ES523873A0 - Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas. - Google Patents

Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.

Info

Publication number: ES523873A0
Authority: ES; Spain
Prior art keywords: sub; integer; hydrogen; formula; phenyl
Prior art date: 1981-06-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES523873A

Other languages

English (en)

Other versions

ES8507461A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merrell Toraude et Cie

Original Assignee

Merrell Toraude et Cie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-06-01

Filing date

1983-07-05

Publication date

1985-10-01

1983-07-05 Application filed by Merrell Toraude et Cie filed Critical Merrell Toraude et Cie

1985-10-01 Publication of ES8507461A1 publication Critical patent/ES8507461A1/es

1985-10-01 Publication of ES523873A0 publication Critical patent/ES523873A0/es

Status Granted legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000002899 monoamine oxidase inhibitor Substances 0.000 title abstract 2
229940123685 Monoamine oxidase inhibitor Drugs 0.000 title 1
150000001412 amines Chemical class 0.000 title 1
-1 3,4-methylendioxyphenyl Chemical group 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 3
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 2
229910052794 bromium Inorganic materials 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 1
229940082992 antihypertensives mao inhibitors Drugs 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
- C07C33/483—Monocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/40—Halogenated unsaturated alcohols
- C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
- C07C33/48—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
- C07C33/486—Polycyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Furan Compounds (AREA)
Indole Compounds (AREA)
Treatment Of Sludge (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Purification Treatments By Anaerobic Or Anaerobic And Aerobic Bacteria Or Animals (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pretreatment Of Seeds And Plants (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

ES523873A 1981-06-01 1983-07-05 Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas. Granted ES523873A0 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/268,555 US4454158A (en)	1981-06-01	1981-06-01	Allyl amine MAO inhibitors

Publications (2)

Publication Number	Publication Date
ES8507461A1 ES8507461A1 (es)	1985-10-01
ES523873A0 true ES523873A0 (es)	1985-10-01

Family

ID=23023513

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
ES512699A Granted ES512699A0 (es)	1981-06-01	1982-05-31	Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.
ES523875A Granted ES523875A0 (es)	1981-06-01	1983-07-05	Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699
ES523873A Granted ES523873A0 (es)	1981-06-01	1983-07-05	Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa, especialmente fluoralilaminas.
ES523874A Expired ES8503638A1 (es)	1981-06-01	1983-07-05	Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
ES512699A Granted ES512699A0 (es)	1981-06-01	1982-05-31	Procedimiento para preparar compuestos inhibidores de alil aminamonoamina oxidasa.
ES523875A Granted ES523875A0 (es)	1981-06-01	1983-07-05	Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa. desglose de la patente de invencion n 512.699

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES523874A Expired ES8503638A1 (es)	1981-06-01	1983-07-05	Procedimiento para preparar compuestos inhibidores de alil amina monoamina oxidasa para la composicion de productos farmaceuticos.

Country Status (18)

Country	Link
US (1)	US4454158A (es)
EP (1)	EP0067105B1 (es)
JP (1)	JPS5823649A (es)
KR (1)	KR890002756B1 (es)
AT (1)	ATE29875T1 (es)
AU (2)	AU550607B2 (es)
CA (2)	CA1187500A (es)
DE (1)	DE3277371D1 (es)
DK (1)	DK244282A (es)
ES (4)	ES512699A0 (es)
GB (2)	GB2100255B (es)
GR (1)	GR78033B (es)
IE (1)	IE53456B1 (es)
IL (2)	IL65808A (es)
MX (1)	MX9202950A (es)
NO (1)	NO152837C (es)
NZ (1)	NZ200644A (es)
ZA (1)	ZA823633B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4699928A (en) *	1984-07-13	1987-10-13	Merrell Dow Pharmaceuticals Inc.	Fluoroallylamine derivatives
NZ214697A (en) *	1984-12-31	1988-10-28	Merrell Dow Pharma	B-methylene-2- and 3-furanethanamine and pharmaceutical compositions
US4703058A (en) *	1984-12-31	1987-10-27	Merrell Dow Pharmaceuticals Inc.	β-methylene furanethanamines and use as anti-hypertensive agents
NZ214698A (en) *	1984-12-31	1988-08-30	Merrell Dow Pharma	Thiophene derivatives and pharmaceutical compositions containing such
US4650907A (en) *	1985-12-05	1987-03-17	Merrell Dow Pharmaceuticals Inc.	Nonaromatic fluoroallylamine MAO inhibitors
ATE71933T1 (de) *	1985-12-05	1992-02-15	Merrell Dow Pharma	Nichtaromatische fluoralkylamin-mao-inhibitoren.
US4822812A (en) *	1987-05-21	1989-04-18	Merrell Dow Pharmaceuticals Inc.	β-(Fluoromethylene)-5-hydroxytryptophan and derivatives and their use as prodrugs for MAO inhibition
NZ224982A (en) *	1987-06-16	1990-08-28	Merrell Dow Pharma	E-2-(p-fluorophenethyl)-3-fluoroallylamine and its pharmaceutical compositions
US4943593A (en) *	1988-02-25	1990-07-24	Merrell Dow Pharmaceuticals Inc.	Inhibitors of lysyl oxidase
US4965288A (en) *	1988-02-25	1990-10-23	Merrell Dow Pharmaceuticals Inc.	Inhibitors of lysyl oxidase
US5059714A (en) *	1988-02-25	1991-10-22	Merrell Dow Pharmaceuticals Inc.	Inhibitors of lysyl oxidase
AU618076B2 (en) *	1988-02-25	1991-12-12	Merrell Dow Pharmaceuticals Inc.	Inhibitors of lysyloxidase
US5182297A (en) *	1988-02-25	1993-01-26	Merrell Dow Pharmaceuticals Inc.	Inhibitors of lysyl oxidase
US5252608A (en) *	1988-02-25	1993-10-12	Merrell Dow Pharmaceuticals Inc.	Inhibitors of lysyl oxidase
US5120764A (en) *	1988-11-01	1992-06-09	Merrell Dow Pharmaceuticals Inc.	Inhibitors of lysyl oxidase
US4981868A (en) *	1989-07-25	1991-01-01	Merrell Dow Pharmaceutical	Pharmaceutically active 3-heteroaryl-2-fluoro-1-olefins
PL183266B1 (pl) *	1995-03-02	2002-06-28	Scherer Ltd R P	Doustna kompozycja farmaceutyczna,sposób wytwarzania doustnej kompozycji farmaceutycznej oraz zastosowanie doustnej kompozycji farmaceutycznej
WO2007120528A2 (en) *	2006-03-31	2007-10-25	La Jolla Pharmaceutical Company	Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
US20100160311A1 (en) *	2006-07-13	2010-06-24	Basf Se	Fungicidal Azolopyrimidines, Process for Their Preparation and Their Use For Controlling Harmful Fungi, and Also Compositions Comprising Them
WO2009055002A1 (en) *	2007-10-24	2009-04-30	La Jolla Pharmaceutical Company	Combined inhibitors of cyclooxygenase and semicarbazide-sensitive amine oxidase (ssao) (vascular adhesion protein, vap-1)
CA2706465A1 (en)	2007-11-21	2009-05-28	Pharmaxis Ltd.	Haloallylamine inhibitors of ssao/vap-1 and uses therefor
SI2844637T1 (en)	2012-05-02	2018-07-31	Boehringer Ingelheim International Gmbh	Substituted 3-haloallylamine inhibitors of ssao and uses thereof
WO2015087094A1 (en) *	2013-12-10	2015-06-18	Semmelweis Egyetem	New arylalkenylpropargylamine derivatives exhibiting neuroprotective action for the treatment of neurodegenerative diseases
CN109153642B (zh)	2016-02-12	2022-05-17	法玛西斯有限公司	赖氨酰氧化酶的吲哚及氮杂吲哚卤化烯丙胺衍生物抑制剂及其用途
CA3105599A1 (en)	2018-08-03	2020-02-06	Pharmaxis Ltd.	Haloallylamine sulfone derivative inhibitors of lysyl oxidases and uses thereof
WO2021155439A1 (en)	2020-02-05	2021-08-12	Pharmaxis Ltd.	Bioprobes for lysyl oxidases and uses thereof
US12233056B2 (en)	2022-04-06	2025-02-25	Syntara Limited	Lysyl oxidase inhibitors for treating myeloid malignancies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2343038A1 (de) *	1973-08-25	1975-03-06	Hoechst Ag	2,3-diaryl-3-halogenallylamine und verfahren zu ihrer herstellung
SE7809127L (sv) *	1978-08-30	1980-03-01	Claesson Alf	Allenaminer

1981
- 1981-06-01 US US06/268,555 patent/US4454158A/en not_active Expired - Lifetime
1982
- 1982-05-17 IL IL65808A patent/IL65808A/xx not_active IP Right Cessation
- 1982-05-17 NZ NZ200644A patent/NZ200644A/en unknown
- 1982-05-21 GB GB8214854A patent/GB2100255B/en not_active Expired
- 1982-05-25 IE IE1246/82A patent/IE53456B1/en not_active IP Right Cessation
- 1982-05-25 ZA ZA823633A patent/ZA823633B/xx unknown
- 1982-05-27 AU AU84238/82A patent/AU550607B2/en not_active Ceased
- 1982-05-27 EP EP82400991A patent/EP0067105B1/en not_active Expired
- 1982-05-27 AT AT82400991T patent/ATE29875T1/de active
- 1982-05-27 DE DE8282400991T patent/DE3277371D1/de not_active Expired
- 1982-05-28 CA CA000403943A patent/CA1187500A/en not_active Expired
- 1982-05-28 NO NO821799A patent/NO152837C/no not_active IP Right Cessation
- 1982-05-28 DK DK244282A patent/DK244282A/da not_active Application Discontinuation
- 1982-05-31 GR GR68306A patent/GR78033B/el unknown
- 1982-05-31 ES ES512699A patent/ES512699A0/es active Granted
- 1982-05-31 KR KR8202435A patent/KR890002756B1/ko not_active Expired
- 1982-06-01 JP JP57092250A patent/JPS5823649A/ja active Granted
1983
- 1983-07-05 ES ES523875A patent/ES523875A0/es active Granted
- 1983-07-05 ES ES523873A patent/ES523873A0/es active Granted
- 1983-07-05 ES ES523874A patent/ES8503638A1/es not_active Expired
1984
- 1984-11-15 GB GB08428858A patent/GB2152039B/en not_active Expired
1985
- 1985-03-13 CA CA000476463A patent/CA1204759A/en not_active Expired
- 1985-07-17 IL IL75829A patent/IL75829A0/xx unknown
1986
- 1986-01-02 AU AU51805/86A patent/AU576281B2/en not_active Ceased
1992
- 1992-06-17 MX MX9202950A patent/MX9202950A/es unknown

Also Published As

Publication number	Publication date
NO821799L (no)	1982-12-02
ES8402810A1 (es)	1984-03-01
ES8507461A1 (es)	1985-10-01
IL75829A0 (en)	1985-11-29
EP0067105A2 (en)	1982-12-15
GB2152039A (en)	1985-07-31
IL65808A0 (en)	1982-08-31
GB8428858D0 (en)	1984-12-27
ZA823633B (en)	1983-03-30
GR78033B (es)	1984-09-26
AU550607B2 (en)	1986-03-27
GB2100255A (en)	1982-12-22
CA1187500A (en)	1985-05-21
AU8423882A (en)	1983-02-03
AU576281B2 (en)	1988-08-18
IE821246L (en)	1982-12-01
MX9202950A (es)	1992-07-01
US4454158B1 (es)	1992-12-22
JPH0422898B2 (es)	1992-04-20
NO152837B (no)	1985-08-19
KR890002756B1 (ko)	1989-07-27
DE3277371D1 (en)	1987-10-29
KR830010044A (ko)	1983-12-24
GB2152039B (en)	1986-04-30
ES523874A0 (es)	1985-04-16
ES8503638A1 (es)	1985-04-16
CA1204759A (en)	1986-05-20
NO152837C (no)	1985-11-27
ATE29875T1 (de)	1987-10-15
ES8503639A1 (es)	1985-04-16
JPS5823649A (ja)	1983-02-12
EP0067105A3 (en)	1984-02-22
DK244282A (da)	1982-12-02
EP0067105B1 (en)	1987-09-23
IE53456B1 (en)	1988-11-23
ES512699A0 (es)	1984-03-01
NZ200644A (en)	1986-06-11
ES523875A0 (es)	1985-04-16
GB2100255B (en)	1985-10-23
US4454158A (en)	1984-06-12
AU5180586A (en)	1986-06-12
IL65808A (en)	1986-12-31

Legal Events

Date	Code	Title	Description
2007-12-16	FD1A	Patent lapsed	Effective date: 20000619

Publication	Publication Date	Title
US4454158B1 (es)	1992-12-22
FI822943A0 (fi)	1982-08-24	Tromboxansyntetas-inhibitorer, processer foer deras framstaellning och farmaceutiska kompositioner innehaollande dessa
NZ517696A (en)	2004-12-24	Biaryl ether derivatives useful as monoamine reuptake inhibitors
DK0783486T3 (da)	2000-01-31	Hidtil ukendte prostaglandinsynthaseinhibitorer
YU31392A (sh)	1994-12-28	Derivati heterocikličnih-cikličnih amina
KR900007406A (ko)	1990-06-01	리실 옥시마제의 억제제
DE60324685D1 (de)	2008-12-24	2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin-wiederaufnahme-inhibitoren
RU94045271A (ru)	1996-10-10	Применение 2-фенил-3-ароилбензотиофенов для ингибирования синдрома тернера
EP0202062A3 (en)	1987-08-19	Quinuclidine derivatives
EA199600007A3 (ru)	1996-12-30	Новые трициклические производные, способ их получения, способы получения оптически активных или рацемических колхицина и тиоколхицина, их аналогов или производных с использованием трициклических соединений и промежуточные продукты синтеза
PT975588E (pt)	2004-02-27	Compostos antipicornavirais, composicoes que os contem e metodos para a sua utilizacao
CA1264753C (en)	1990-01-23	2-PYRIDYLCARBOXAMIDES
CO5040081A1 (es)	2001-05-29	Nuevos compuestos vidad farmaaceutica
DK1037871T3 (da)	2002-10-14	Nye antiarytmiske forbindelser
SE7809127L (sv)	1980-03-01	Allenaminer
MY104048A (en)	1993-10-30	New allylaminoethylazoles.
AU6924094A (en)	1994-12-20	PsoralenTM* derivatives, their preparation and use
JPS55160757A (en)	1980-12-13	Novel cyclopentanecarboxylic acid derivative and its preparation