ES529593A0 - Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona - Google Patents

Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona

Info

Publication number
ES529593A0
ES529593A0 ES529593A ES529593A ES529593A0 ES 529593 A0 ES529593 A0 ES 529593A0 ES 529593 A ES529593 A ES 529593A ES 529593 A ES529593 A ES 529593A ES 529593 A0 ES529593 A0 ES 529593A0
Authority
ES
Spain
Prior art keywords
derivatives
benzazoninone
benzazocinone
procedure
preparing new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES529593A
Other languages
English (en)
Other versions
ES8606286A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of ES529593A0 publication Critical patent/ES529593A0/es
Publication of ES8606286A1 publication Critical patent/ES8606286A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES529593A 1983-02-10 1984-02-09 Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona Expired ES8606286A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/465,696 US4470988A (en) 1983-02-10 1983-02-10 Benzazocinone and benzazoninone derivatives, and their pharmaceutical use

Publications (2)

Publication Number Publication Date
ES529593A0 true ES529593A0 (es) 1986-04-01
ES8606286A1 ES8606286A1 (es) 1986-04-01

Family

ID=23848809

Family Applications (2)

Application Number Title Priority Date Filing Date
ES529593A Expired ES8606286A1 (es) 1983-02-10 1984-02-09 Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona
ES544051A Expired ES8700240A1 (es) 1983-02-10 1985-06-11 Procedimiento para preparar nuevos derivados de benzazocino-na y de benzaconinona

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES544051A Expired ES8700240A1 (es) 1983-02-10 1985-06-11 Procedimiento para preparar nuevos derivados de benzazocino-na y de benzaconinona

Country Status (20)

Country Link
US (1) US4470988A (es)
EP (1) EP0119161B1 (es)
JP (1) JPS59172474A (es)
KR (1) KR840007872A (es)
AT (1) ATE44279T1 (es)
AU (1) AU2443184A (es)
CA (1) CA1218989A (es)
DD (1) DD216717A5 (es)
DE (1) DE3478810D1 (es)
DK (1) DK58084A (es)
ES (2) ES8606286A1 (es)
FI (1) FI840463A7 (es)
GR (1) GR81766B (es)
HU (1) HU193671B (es)
IE (1) IE56816B1 (es)
IL (1) IL70882A0 (es)
NO (1) NO840486L (es)
NZ (1) NZ207090A (es)
PT (1) PT78064B (es)
ZA (1) ZA84959B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4873235A (en) * 1982-06-01 1989-10-10 Merck & Co., Inc. Benzofused lactams as antihypertensives
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
EP0166357A3 (en) * 1984-06-26 1988-10-26 Merck & Co. Inc. Benzofused lactams and pharmaceutical compositions containing them
EP0166354B1 (en) * 1984-06-26 1992-08-05 Merck & Co. Inc. Benzofused lactam compounds and pharmaceutical compositions containing them
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
US4785089A (en) * 1985-06-13 1988-11-15 Ciba-Geigy Corporation Novel sulfonic acid esters and their preparation
DE3704661A1 (de) * 1987-02-14 1988-08-25 Hoechst Ag Annelierte azepinon- und azocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung
US5145864A (en) * 1987-09-15 1992-09-08 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US5110813A (en) * 1987-09-15 1992-05-05 Alcoholism And Drug Addiction Research Foundation Reduction of voluntary alcohol consumption by treatment with angiotensin converting enzyme inhibitors
US5428031A (en) * 1991-12-03 1995-06-27 Merck & Co., Inc. Methods of treating cardiac arrhythmia
US5552397A (en) * 1992-05-18 1996-09-03 E. R. Squibb & Sons, Inc. Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
RU2124503C1 (ru) 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
CA2176019A1 (en) * 1993-11-22 1995-06-01 John J. Baldwin 3-acylaminobenzazepines
ES2139933T3 (es) * 1994-08-18 2000-02-16 Merck & Co Inc 2,3-dihidro-1-(2,2,2-trifluoroetil)-2-oxo-5-fenil-1h-1,4-benzodiacepinas.
US5587375A (en) * 1995-02-17 1996-12-24 Bristol-Myers Squibb Company Azepinone compounds useful in the inhibition of ACE and NEP
US5877313A (en) 1995-05-17 1999-03-02 Bristol-Myers Squibb Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
US5700797A (en) * 1995-06-07 1997-12-23 Merck & Co, Inc. N-(2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)-3-amides
US5631251A (en) * 1995-06-07 1997-05-20 Merck & Co., Inc. 5-cyclopropyl-1,4 benzodiazepine-2-ones
US5726171A (en) * 1995-06-07 1998-03-10 Merck & Co Inc N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo B! 1,4!diazepin-3yl)-acetamides
US5691331A (en) * 1995-06-07 1997-11-25 Merck & Co., Inc. N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides
US5650408A (en) * 1995-06-07 1997-07-22 Karanewsky; Donald S. Thiazolo benzazepine containing dual action inhibitors
US5635504A (en) * 1995-06-07 1997-06-03 Bristol-Myers Squibb Co. Diazepine containing dual action inhibitors
JPH11506760A (ja) * 1995-06-07 1999-06-15 メルク エンド カンパニー インコーポレーテッド 新規なｎ−（２，４−ジオキソ−２，３，４，５−テトラヒドロ−１ｈ−１，５−ベンゾジアゼピン−３イル）−３−アミド
EP2544765A1 (en) 2010-03-11 2013-01-16 Merck Patent GmbH Fibers in therapy and cosmetics
CN118748991A (zh) * 2022-03-23 2024-10-08 浙江华海药业股份有限公司 一种纯化左乙拉西坦中间体的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395150A (en) * 1965-02-26 1968-07-30 Squibb & Sons Inc Benzothiazepine carboxamides and derivatives thereof
GB1191963A (en) * 1968-02-07 1970-05-13 Ucb Sa Heterocyclic Compounds
GB1183442A (es) * 1968-02-23 1970-03-04
LU79008A1 (de) * 1978-02-03 1979-09-06 Byk Gulden Lomberg Chem Fab W-(n-alkyl-n-benzoyl-amino)-phenylalkansaeuren,ihre verwendung und herstellung sowie sie enthaltende arzneimittel
IL63540A0 (en) * 1980-08-18 1981-11-30 Merck & Co Inc Substituted enantholactam derivatives as antihypertensives
GR74625B (es) * 1980-08-18 1984-06-29 Merck & Co Inc
GR74635B (es) * 1980-08-18 1984-06-29 Merck & Co Inc
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents

Also Published As

Publication number Publication date
EP0119161A3 (en) 1986-06-11
CA1218989A (en) 1987-03-10
NZ207090A (en) 1985-10-11
DK58084A (da) 1984-08-11
FI840463A0 (fi) 1984-02-06
ES8700240A1 (es) 1986-09-16
EP0119161A2 (de) 1984-09-19
ZA84959B (en) 1984-09-26
DK58084D0 (da) 1984-02-09
PT78064B (en) 1986-06-02
AU2443184A (en) 1984-08-16
EP0119161B1 (de) 1989-06-28
DD216717A5 (de) 1984-12-19
HU193671B (en) 1987-11-30
FI840463A7 (fi) 1984-08-11
GR81766B (es) 1984-12-12
KR840007872A (ko) 1984-12-11
US4470988A (en) 1984-09-11
NO840486L (no) 1984-08-13
JPH0449545B2 (es) 1992-08-11
ES8606286A1 (es) 1986-04-01
JPS59172474A (ja) 1984-09-29
PT78064A (en) 1984-03-01
IL70882A0 (en) 1984-05-31
IE56816B1 (en) 1991-12-18
DE3478810D1 (en) 1989-08-03
IE840301L (en) 1984-08-10
ATE44279T1 (de) 1989-07-15
ES544051A0 (es) 1986-09-16

Similar Documents

Publication Publication Date Title
ES529593A0 (es) Procedimiento para preparar nuevos derivados de benzazocinona y de benzazoninona
ATE12042T1 (de) Aminosaeurederivate und ihre therapeutische verwendung.
SE8503680L (sv) Indolderivat
ATE267200T1 (de) Bicyclische kinase inhibitoren
EA200000298A1 (ru) Агонисты простагландинов и их применение для лечения заболеваний костей
DK0922045T3 (da) Bicykliske pyrimidinderivater og deres anvendelse som antikoagulanter
DK0813525T3 (da) Benzamidinderivater, deres fremstilling og anvendelse som antikoagulanter
TR200002480T2 (tr) İzaşemi tedavisi için guanidin türevleri
UA39166C2 (uk) Похідні n-гідроксисечовини, що є інгібіторами ліпоксигенази у ссавців, спосіб їх одержання і спосіб інгібування ліпоксигенази у ссавців
AR024138A1 (es) Inhibidores de la proliferacion celular
DK17983D0 (da) Fremgangsmade til fremstilling af 6-substituerede s-triazol(3,4-a)-ftalazin-derivater
BR9811099A (pt) Inibidores de urocinase
SG48298A1 (en) Saccharin deriatives useful as proteolytic enzymeinhibitors and preparation of
DK229187D0 (da) 1-substituerede imidazolderivater, 2-thion-tautomere og ikke-toksiske, farmaceutisk acceptable salte deraf
NO840048L (no) Disubstituerte prolinderivater, fremgangsmaate til deres fremstilling og deres anvendelse
ES507807A0 (es) Procedimiento para la obtencion de derivados triciclicos de citosina.
ES496038A0 (es) Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
BG45552A3 (bg) Метод за получаване на 2-фенил-хексахидро-1,2,4- триазин-3,5-диони
DK0758312T3 (da) Substituerede fusionerede og broforbundne bicykliske forbindelser som terapeutiske midler
SE9604582D0 (sv) Novel compounds
NO821841L (no) Mettede aminocyklitderivater, deres fremstilling og legemiddel inneholdende dem
ES527854A0 (es) Procedimiento de preparar compuestos tratamiento de la hipertension
SE9603726D0 (sv) Novel compounds

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401