ES540841A0 - Un procedimiento compuesto de espiro 2h-1,4-benzodioxepin-3 (5h)4'-piperidina y -3'-pirrolidina - Google Patents

Un procedimiento compuesto de espiro 2h-1,4-benzodioxepin-3 (5h)4'-piperidina y -3'-pirrolidina

Info

Publication number: ES540841A0
Authority: ES; Spain
Prior art keywords: benzodioxepin; piperidine; pirrolidine; compounds; composite spiral
Prior art date: 1982-08-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES540841A

Other languages

English (en)

Other versions

ES8602800A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharmaceuticals Inc

Original Assignee

Hoechst Roussel Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-08-20

Filing date

1985-03-01

Publication date

1985-12-01

1985-03-01 Application filed by Hoechst Roussel Pharmaceuticals Inc filed Critical Hoechst Roussel Pharmaceuticals Inc

1985-12-01 Publication of ES540841A0 publication Critical patent/ES540841A0/es

1985-12-01 Publication of ES8602800A1 publication Critical patent/ES8602800A1/es

Status Expired legal-status Critical Current

Links

239000002131 composite material Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
206010020772 Hypertension Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
230000003276 anti-hypertensive effect Effects 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000003003 spiro group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
- C07D321/02—Seven-membered rings
- C07D321/10—Seven-membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Other In-Based Heterocyclic Compounds (AREA)

ES540841A 1982-08-20 1985-03-01 Un procedimiento compuesto de espiro 2h-1,4-benzodioxepin-3 (5h)4'-piperidina y -3'-pirrolidina Expired ES8602800A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/410,155 US4405631A (en)	1982-08-20	1982-08-20	Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'pyrrolidine] compounds and their use as antihypertensive agents

Publications (2)

Publication Number	Publication Date
ES540841A0 true ES540841A0 (es)	1985-12-01
ES8602800A1 ES8602800A1 (es)	1985-12-01

Family

ID=23623465

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES525013A Expired ES8505685A1 (es)	1982-08-20	1983-08-18	Un procedimiento para preparar compuestos de espiro (2h-1,4-benzodioxepin-3(5h)4'-piperidina y -3'-pirrolidina)
ES540841A Expired ES8602800A1 (es)	1982-08-20	1985-03-01	Un procedimiento compuesto de espiro 2h-1,4-benzodioxepin-3 (5h)4'-piperidina y -3'-pirrolidina

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES525013A Expired ES8505685A1 (es)	1982-08-20	1983-08-18	Un procedimiento para preparar compuestos de espiro (2h-1,4-benzodioxepin-3(5h)4'-piperidina y -3'-pirrolidina)

Country Status (20)

Country	Link
US (1)	US4405631A (es)
EP (1)	EP0102034B1 (es)
JP (1)	JPS5953489A (es)
KR (1)	KR840005729A (es)
AT (1)	ATE33656T1 (es)
AU (1)	AU576473B2 (es)
CA (1)	CA1210764A (es)
DE (1)	DE3376327D1 (es)
DK (1)	DK381983A (es)
ES (2)	ES8505685A1 (es)
FI (1)	FI832959A7 (es)
GR (1)	GR78667B (es)
HU (1)	HU191874B (es)
IL (1)	IL69525A0 (es)
MA (1)	MA19881A1 (es)
NO (1)	NO833001L (es)
NZ (1)	NZ205320A (es)
PH (1)	PH18839A (es)
PT (1)	PT77223B (es)
ZA (1)	ZA836127B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4472580A (en) *	1982-08-20	1984-09-18	Hoechst-Roussel Pharmaceuticals Incorporated	Spiro (2H-1,4-benzodioxepin-3 (5H)4-piperidine and -3-pyrrolidine) compounds and their use as anti-hypertensive agents
US4521537A (en) *	1982-08-20	1985-06-04	Hoechst-Roussel Pharmaceuticals Incorporated	Spiro[2H-1,4-benzodioxepin-3(5H)4'-piperidine and -3'-pyrrolidine] compounds and their use as antihypertensive agents
US4751223A (en) *	1986-10-14	1988-06-14	Hoechst-Roussel Pharmaceuticals, Inc.	Antiinflammatory and analgesic aminoalkyl tetracyclic benzodiazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1312894A (fr) *	1962-01-29	1962-12-21	Geigy Ag J R	Nouveaux composés hétérocycliques à 2 atomes d'oxygène dans le cycle et leur préparation
CH469736A (de) *	1966-06-28	1969-03-15	Geigy Ag J R	Verfahren zur Herstellung von neuen Heterospiroalkanen
US3679666A (en) *	1969-04-03	1972-07-25	Hoffmann La Roche	4-(4-hydroxypiperidino)-4'-fluorobutyrophenones

1982
- 1982-08-20 US US06/410,155 patent/US4405631A/en not_active Expired - Fee Related
1983
- 1983-08-17 GR GR72231A patent/GR78667B/el unknown
- 1983-08-18 PH PH29413A patent/PH18839A/en unknown
- 1983-08-18 NZ NZ205320A patent/NZ205320A/en unknown
- 1983-08-18 DE DE8383108156T patent/DE3376327D1/de not_active Expired
- 1983-08-18 KR KR1019830003853A patent/KR840005729A/ko not_active Ceased
- 1983-08-18 ES ES525013A patent/ES8505685A1/es not_active Expired
- 1983-08-18 FI FI832959A patent/FI832959A7/fi not_active Application Discontinuation
- 1983-08-18 AT AT83108156T patent/ATE33656T1/de not_active IP Right Cessation
- 1983-08-18 EP EP83108156A patent/EP0102034B1/en not_active Expired
- 1983-08-19 DK DK381983A patent/DK381983A/da not_active Application Discontinuation
- 1983-08-19 PT PT77223A patent/PT77223B/pt unknown
- 1983-08-19 NO NO833001A patent/NO833001L/no unknown
- 1983-08-19 JP JP58150473A patent/JPS5953489A/ja active Pending
- 1983-08-19 ZA ZA836127A patent/ZA836127B/xx unknown
- 1983-08-19 IL IL69525A patent/IL69525A0/xx unknown
- 1983-08-19 HU HU832920A patent/HU191874B/hu unknown
- 1983-08-19 CA CA000434928A patent/CA1210764A/en not_active Expired
- 1983-08-19 AU AU18169/83A patent/AU576473B2/en not_active Ceased
- 1983-08-20 MA MA20103A patent/MA19881A1/fr unknown
1985
- 1985-03-01 ES ES540841A patent/ES8602800A1/es not_active Expired

Also Published As

Publication number	Publication date
PH18839A (en)	1985-10-10
ES525013A0 (es)	1985-06-01
CA1210764A (en)	1986-09-02
ZA836127B (en)	1984-04-25
EP0102034A1 (en)	1984-03-07
IL69525A0 (en)	1983-11-30
AU576473B2 (en)	1988-09-01
DK381983A (da)	1984-02-21
DE3376327D1 (en)	1988-05-26
DK381983D0 (da)	1983-08-19
FI832959A0 (fi)	1983-08-18
NZ205320A (en)	1987-05-29
PT77223B (en)	1986-03-18
HU191874B (en)	1987-04-28
MA19881A1 (fr)	1984-04-01
ES8505685A1 (es)	1985-06-01
JPS5953489A (ja)	1984-03-28
ATE33656T1 (de)	1988-05-15
GR78667B (es)	1984-09-27
EP0102034B1 (en)	1988-04-20
PT77223A (en)	1983-09-01
KR840005729A (ko)	1984-11-16
US4405631A (en)	1983-09-20
NO833001L (no)	1984-02-21
ES8602800A1 (es)	1985-12-01
AU1816983A (en)	1984-02-23
FI832959A7 (fi)	1984-02-21

Publication	Publication Date	Title
ES2001996A6 (es)	1988-07-01	Procedimiento para preparar composiciones farmaceuticas contra enfermedades cronicas de trasplante frente a hospedante y contra enfermedades de autoinmunidad.
UA66825C2 (uk)	2004-06-15	Азаполіциклічні сполуки, конденсовані з арилом, фармацевтична композиція, спосіб лікування та спосіб зниження нікотинової залежності
IL127244A (en)	2005-11-20	Substituted amines, methods of their preparation and pharmaceutical compositions containing them
BG102999A (bg)	1999-09-30	Нови 2,3 дизаместени-4(3н)-хиназолинони
DE69430440D1 (de)	2002-05-23	Zusammensetzungen zur inhibition von retroviraler verbreitung, die 2',3'-dideoxy-inosin und hydroxyharnstoff enthalten
GR3007385T3 (es)	1993-07-30
EP0229444A3 (en)	1990-11-28	Medicaments for the treatment of anxiety
ZA852391B (en)	1985-11-27	Substituted benzopyrans,processes for their preparation,and their use in medicaments
ES540841A0 (es)	1985-12-01	Un procedimiento compuesto de espiro 2h-1,4-benzodioxepin-3 (5h)4'-piperidina y -3'-pirrolidina
GB8720600D0 (en)	1987-10-07	Pharmaceutical compositions
MX9709453A (es)	1998-02-28	Composicion farmaceutica oral de compuestos de piperidinoalcanol en forma de solucion.
ZA87773B (en)	1988-10-26	5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
ES553207A0 (es)	1987-08-01	Un procedimiento para la preparacion de una octahidroindolizina
EP0093497A3 (en)	1985-03-20	Anthelmintic treatment
AU624733B2 (en)	1992-06-18	Naphthalene and tetrahydronaphthalene substituted gem- diphosphonate compounds and their use in therapy
ZW6789A1 (en)	1989-08-30	&-adrenergic receptor antagonists
MY106961A (en)	1995-08-30	Antiviral tetrahydroimidazo[1,4] benzodiazepines
JPS57159715A (en)	1982-10-01	Synergism of analgesic
CA1263380C (en)	1989-11-28	MYCAMINOSYLTYLONOLIDE COMPOUNDS SUBSTITUTED FOR C-23 AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM
MY106292A (en)	1995-04-29	(alpha)-adrenergic receptor antagonists.
MX9703610A (es)	1998-06-30	Nuevas (5,6)-heteroaril condensado-pirimidin-4-onas 2,3 disustituidas.
EP0178176A3 (en)	1988-03-23	Tetrahydro-1,2,4-oxadiazine-5-thione derivatives