ES544954A0 - Procedimiento para preparar derivados de pirazol (3,4-d)-pi-ridin-3-ona - Google Patents
Procedimiento para preparar derivados de pirazol (3,4-d)-pi-ridin-3-onaInfo
- Publication number
- ES544954A0 ES544954A0 ES544954A ES544954A ES544954A0 ES 544954 A0 ES544954 A0 ES 544954A0 ES 544954 A ES544954 A ES 544954A ES 544954 A ES544954 A ES 544954A ES 544954 A0 ES544954 A0 ES 544954A0
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- optionally substituted
- receptor modulators
- benzodiazepine receptor
- fused
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 102000004300 GABA-A Receptors Human genes 0.000 abstract 2
- 108090000839 GABA-A Receptors Proteins 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000005956 isoquinolyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62870384A | 1984-07-09 | 1984-07-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES544954A0 true ES544954A0 (es) | 1987-02-16 |
| ES8703462A1 ES8703462A1 (es) | 1987-02-16 |
Family
ID=24519969
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544954A Expired ES8703462A1 (es) | 1984-07-09 | 1985-07-08 | Procedimiento para preparar derivados de pirazol (3,4-d)-pi-ridin-3-ona |
| ES551992A Expired ES8706674A1 (es) | 1984-07-09 | 1986-02-14 | Procedimiento para preparar derivados de pirazol 3,4-d-priridin-3-ona. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES551992A Expired ES8706674A1 (es) | 1984-07-09 | 1986-02-14 | Procedimiento para preparar derivados de pirazol 3,4-d-priridin-3-ona. |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0168350B1 (es) |
| JP (1) | JPS6140285A (es) |
| AT (1) | ATE75744T1 (es) |
| AU (1) | AU584906B2 (es) |
| CA (1) | CA1263651A (es) |
| DD (1) | DD238235A5 (es) |
| DE (1) | DE3585973D1 (es) |
| DK (1) | DK168952B1 (es) |
| ES (2) | ES8703462A1 (es) |
| FI (1) | FI80695C (es) |
| GR (1) | GR851685B (es) |
| HU (1) | HU198929B (es) |
| IE (1) | IE58743B1 (es) |
| IL (1) | IL75745A (es) |
| NO (1) | NO163056C (es) |
| NZ (1) | NZ212669A (es) |
| PT (1) | PT80777B (es) |
| ZA (1) | ZA855126B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2566405B1 (fr) * | 1984-06-25 | 1986-09-26 | Roussel Uclaf | Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus |
| CA1306260C (en) * | 1985-10-18 | 1992-08-11 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
| ATE79621T1 (de) * | 1986-11-25 | 1992-09-15 | Ciba Geigy Ag | Einige cycloalka(b>pyrazolo(3,4-d>pyridin-3-onderivate. |
| DE3888864T2 (de) * | 1987-04-09 | 1994-10-13 | Du Pont | Insektizide substituierte Indazole. |
| US5378848A (en) * | 1992-02-12 | 1995-01-03 | Shionogi & Co., Ltd. | Condensed imidazopyridine derivatives |
| GB9713707D0 (en) * | 1997-06-27 | 1997-09-03 | Merck Sharp & Dohme | Therapeutic agents |
| US6957741B2 (en) | 2001-08-07 | 2005-10-25 | Manfred Franz Axel Freissle | Screening arrangement |
| AR127972A1 (es) * | 2021-12-17 | 2024-03-13 | Pi Industries Ltd | Novedosos compuestos de piridina carboxamida bicíclica sustituida fusionada para combatir hongos fitopatogénicos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0022078B1 (de) * | 1979-06-21 | 1984-07-25 | Ciba-Geigy Ag | Pyrazolochinoline, Verfahren zu ihrer Herstellung, und pharmazeutische Präparate enthaltend diese Verbindungen |
| US4524146A (en) * | 1982-12-08 | 1985-06-18 | Ciba-Geigy Corporation | Certain -2-heterocycle substituted pyrazoloquinolines |
| US4479955A (en) * | 1983-01-10 | 1984-10-30 | Ciba-Geigy Corporation | Heterocycle-fused pyrazolo[3,4-d]pyridin-3-ones as benzodiazepine receptor modulators |
| EP0126970A3 (en) * | 1983-04-27 | 1985-11-06 | Beecham Group Plc | Anxiolytic and anti-depressant thienopyridine derivatives |
-
1985
- 1985-06-28 CA CA000486155A patent/CA1263651A/en not_active Expired
- 1985-07-03 EP EP85810305A patent/EP0168350B1/en not_active Expired - Lifetime
- 1985-07-03 DE DE8585810305T patent/DE3585973D1/de not_active Expired - Lifetime
- 1985-07-03 AT AT85810305T patent/ATE75744T1/de not_active IP Right Cessation
- 1985-07-05 PT PT80777A patent/PT80777B/pt not_active IP Right Cessation
- 1985-07-05 FI FI852672A patent/FI80695C/fi not_active IP Right Cessation
- 1985-07-08 DK DK310785A patent/DK168952B1/da not_active IP Right Cessation
- 1985-07-08 HU HU852640A patent/HU198929B/hu not_active IP Right Cessation
- 1985-07-08 IL IL75745A patent/IL75745A/xx not_active IP Right Cessation
- 1985-07-08 NO NO852747A patent/NO163056C/no unknown
- 1985-07-08 AU AU44675/85A patent/AU584906B2/en not_active Ceased
- 1985-07-08 ES ES544954A patent/ES8703462A1/es not_active Expired
- 1985-07-08 GR GR851685A patent/GR851685B/el unknown
- 1985-07-08 IE IE171285A patent/IE58743B1/en not_active IP Right Cessation
- 1985-07-08 NZ NZ212669A patent/NZ212669A/xx unknown
- 1985-07-08 DD DD85278380A patent/DD238235A5/de not_active IP Right Cessation
- 1985-07-08 ZA ZA855126A patent/ZA855126B/xx unknown
- 1985-07-09 JP JP14937885A patent/JPS6140285A/ja active Pending
-
1986
- 1986-02-14 ES ES551992A patent/ES8706674A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK310785A (da) | 1986-01-10 |
| ES8706674A1 (es) | 1987-07-01 |
| IL75745A0 (en) | 1985-11-29 |
| EP0168350B1 (en) | 1992-05-06 |
| PT80777B (pt) | 1987-10-20 |
| NO852747L (no) | 1986-01-10 |
| DE3585973D1 (de) | 1992-06-11 |
| EP0168350A2 (en) | 1986-01-15 |
| GR851685B (es) | 1985-11-26 |
| NO163056B (no) | 1989-12-18 |
| DD238235A5 (de) | 1986-08-13 |
| FI852672A0 (fi) | 1985-07-05 |
| NO163056C (no) | 1990-03-28 |
| NZ212669A (en) | 1989-04-26 |
| FI852672L (fi) | 1986-01-10 |
| AU584906B2 (en) | 1989-06-08 |
| DK310785D0 (da) | 1985-07-08 |
| IL75745A (en) | 1989-05-15 |
| AU4467585A (en) | 1986-01-16 |
| FI80695B (fi) | 1990-03-30 |
| JPS6140285A (ja) | 1986-02-26 |
| ZA855126B (en) | 1987-03-25 |
| DK168952B1 (da) | 1994-07-18 |
| HUT38632A (en) | 1986-06-30 |
| ES8703462A1 (es) | 1987-02-16 |
| FI80695C (fi) | 1990-07-10 |
| EP0168350A3 (en) | 1987-09-09 |
| CA1263651A (en) | 1989-12-05 |
| ATE75744T1 (de) | 1992-05-15 |
| HU198929B (en) | 1989-12-28 |
| IE58743B1 (en) | 1993-11-03 |
| IE851712L (en) | 1986-01-09 |
| ES551992A0 (es) | 1987-07-01 |
| PT80777A (en) | 1985-08-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970519 |