ES8100275A1 - Un procedimiento para la preparacion de derivados de 5-fluoruracilo - Google Patents

Un procedimiento para la preparacion de derivados de 5-fluoruracilo

Info

Publication number
ES8100275A1
ES8100275A1 ES485554A ES485554A ES8100275A1 ES 8100275 A1 ES8100275 A1 ES 8100275A1 ES 485554 A ES485554 A ES 485554A ES 485554 A ES485554 A ES 485554A ES 8100275 A1 ES8100275 A1 ES 8100275A1
Authority
ES
Spain
Prior art keywords
optionally substituted
radical
compounds
present
bridged alicyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485554A
Other languages
English (en)
Other versions
ES485554A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES8100275A1 publication Critical patent/ES8100275A1/es
Publication of ES485554A0 publication Critical patent/ES485554A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE DERIVADOS DE 5-FLUORUROACILO. CONSISTE EN HACER REACCIONAR 5-FLUORURACILO CON UN ISOACIANATO DE FORMULA RA-N=C=O, OBTENIENDOSE UN DERIVADO DE 5-FLUORURACILO DE FORMULA GENERAL I. OPCIONALMENTE, SE PUEDE HIDROLIZAR EL COMPUESTO RESULTANTE (II), SE OBTIENE UN DERIVADO DE FORMULA GENERAL (III). SE OBTIENEN COMPUESTO DE FORMULA GENERAL (IV). ACTIVIDAD ANTITUMORAL. *FORMULA*
ES485554A 1978-10-30 1979-10-30 Un procedimiento para la preparacion de derivados de 5-fluoruracilo Granted ES485554A0 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB7842426 1978-10-30
GB7909522 1979-03-19
GB7919439 1979-06-04
GB8002195 1980-01-23

Publications (2)

Publication Number Publication Date
ES8100275A1 true ES8100275A1 (es) 1980-11-01
ES485554A0 ES485554A0 (es) 1980-11-01

Family

ID=27449090

Family Applications (1)

Application Number Title Priority Date Filing Date
ES485554A Granted ES485554A0 (es) 1978-10-30 1979-10-30 Un procedimiento para la preparacion de derivados de 5-fluoruracilo

Country Status (3)

Country Link
EP (1) EP0010941B1 (es)
DE (1) DE2962834D1 (es)
ES (1) ES485554A0 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2539412B1 (fr) * 1983-01-13 1986-02-21 Shoichiro Ozaki Derives du 5-fluoruracile et leurs utilisations therapeutiques en tant qu'agents carcinostatiques
IL73840A (en) * 1983-12-19 1988-11-15 Uniroyal Chem Co Inc 2-thio-5-(thio)carbamoyl barbituric acid derivatives,their preparation and pharmaceutical compositions containing them
JPS61204172A (ja) * 1985-03-07 1986-09-10 Nippon Kayaku Co Ltd ５−フルオロウラシル誘導体
DE3781357T2 (de) * 1986-10-09 1993-03-18 Daikin Ind Ltd 5-fluorouracil-derivate, pharmazeutische zubereitung und verwendung.
EP1939186A1 (en) * 2006-12-22 2008-07-02 Sulfidris S.r.l. 5-Fluorouracil derivatives and their use for the treatment of cancer
CN109384730B (zh) * 2017-08-10 2022-02-18 南京友怡医药科技有限公司 1-{3-[对-双-(2-氯乙基)胺基]苯丙胺基}甲酰-5-氟脲嘧啶及制备和应用
CN115850190B (zh) * 2023-01-10 2024-09-10 四川大学 一种5-氟尿嘧啶衍生物及其抗肿瘤用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5324952B2 (es) * 1973-11-28 1978-07-24
JPS5285179A (en) * 1976-01-08 1977-07-15 Mitsui Toatsu Chem Inc Preparation of carbamoylated 5-fluorouracils

Also Published As

Publication number Publication date
EP0010941A1 (en) 1980-05-14
DE2962834D1 (en) 1982-07-01
EP0010941B1 (en) 1982-05-12
ES485554A0 (es) 1980-11-01

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