ES8100659A1 - Procedimiento de preparar acido 4-(n-hexadecilamino)-benzoi-co y sus sales - Google Patents

Procedimiento de preparar acido 4-(n-hexadecilamino)-benzoi-co y sus sales

Info

Publication number
ES8100659A1
ES8100659A1 ES489078A ES489078A ES8100659A1 ES 8100659 A1 ES8100659 A1 ES 8100659A1 ES 489078 A ES489078 A ES 489078A ES 489078 A ES489078 A ES 489078A ES 8100659 A1 ES8100659 A1 ES 8100659A1
Authority
ES
Spain
Prior art keywords
hexadecylamino
benzoic acid
preparing
salt
employing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489078A
Other languages
English (en)
Other versions
ES489078A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Publication of ES489078A0 publication Critical patent/ES489078A0/es
Publication of ES8100659A1 publication Critical patent/ES8100659A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ACIDO 4-N-HEXADECILAMINO-BENZOICO Y SUS SALES. CONSISTE EN HACER REACCIONAR EL ACIDO 4-AMINOBENZOICO Y 1-BROMOHEXADECANO EN UN DISOLVENTE TAL COMO ETANOL EN PRESENCIA DE UNA BASE TAL COMO KOH A TEMPERATURA DE REFLUJO. SE EMPLEA UNA SAL AMONICA O FOSFONICA COMO CATALIZADOR DE TRANSFERENCIA DE FASES. EL TIEMPO DE REACCION ES INFERIOR A 15 HORAS. OPCIONALMENTE EL ACIDO OBTENIDO SE TRANSFORMA EN UNA SAL FISIOLOGICAMENTE ACEPTABLE DEL MISMO. TRATAMIENTO DE ARTERIOSCLEROSIS.
ES489078A 1979-03-09 1980-02-29 Procedimiento de preparar acido 4-(n-hexadecilamino)-benzoi-co y sus sales Expired ES8100659A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU00579/79A YU57979A (en) 1979-03-09 1979-03-09 Process for preparing 4-9n-hexadecylamino0-benzoic acid

Publications (2)

Publication Number Publication Date
ES489078A0 ES489078A0 (es) 1980-12-01
ES8100659A1 true ES8100659A1 (es) 1980-12-01

Family

ID=25550533

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489078A Expired ES8100659A1 (es) 1979-03-09 1980-02-29 Procedimiento de preparar acido 4-(n-hexadecilamino)-benzoi-co y sus sales

Country Status (9)

Country Link
US (1) US4304929A (es)
AT (1) ATA104980A (es)
CS (1) CS214703B2 (es)
DD (1) DD149803A5 (es)
ES (1) ES8100659A1 (es)
HU (1) HU183073B (es)
PL (1) PL222469A1 (es)
SU (1) SU869557A3 (es)
YU (1) YU57979A (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3868416A (en) * 1973-10-01 1975-02-25 American Cyanamid Co Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives
US4154756A (en) * 1977-12-15 1979-05-15 American Cyanamid Company 2-Substituted-4'-(monoalkylamino)-acetophenones

Also Published As

Publication number Publication date
ES489078A0 (es) 1980-12-01
PL222469A1 (es) 1981-01-02
YU57979A (en) 1982-10-31
HU183073B (en) 1984-04-28
CS214703B2 (en) 1982-05-28
US4304929A (en) 1981-12-08
DD149803A5 (de) 1981-07-29
SU869557A3 (ru) 1981-09-30
ATA104980A (de) 1981-11-15

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