ES8101075A1 - Un metodo de preparar nuevas espiro (dibenzo (b,f)oxepinpi- peridinas) - Google Patents

Un metodo de preparar nuevas espiro (dibenzo (b,f)oxepinpi- peridinas)

Info

Publication number
ES8101075A1
ES8101075A1 ES487451A ES487451A ES8101075A1 ES 8101075 A1 ES8101075 A1 ES 8101075A1 ES 487451 A ES487451 A ES 487451A ES 487451 A ES487451 A ES 487451A ES 8101075 A1 ES8101075 A1 ES 8101075A1
Authority
ES
Spain
Prior art keywords
oxepin
dibenz
methods
spiro
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES487451A
Other languages
English (en)
Other versions
ES487451A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES487451A0 publication Critical patent/ES487451A0/es
Publication of ES8101075A1 publication Critical patent/ES8101075A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE ESPIRO-DIBENZO (B,F) OXEPIN.PIPERIDINAS). CONSISTE EN CICLOACILAR UN COMPUESTO DE FORMULA GENERAL (I), EN QUE R ES METILO O UN RADICAL ALCANOILO DE 2 A 6 ATOMOS DE CARBONO, Y Z ES HALOGENO O EL GRUPO HIDROXILO CON UN CATALIZADOR DE LEWIS. SE OBTIENE UN COMPUESTO DE FORMULA GENERAL II. *FORMULA* ANALGESICOS, TRANQUILIZANTES Y ANTICONVULSIVOS.
ES487451A 1979-01-10 1980-01-04 Un metodo de preparar nuevas espiro (dibenzo (b,f)oxepinpi- peridinas) Expired ES8101075A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/002,348 US4198418A (en) 1979-01-10 1979-01-10 Spiro[dibenz(b,f)oxepin-piperidine]s

Publications (2)

Publication Number Publication Date
ES487451A0 ES487451A0 (es) 1980-12-01
ES8101075A1 true ES8101075A1 (es) 1980-12-01

Family

ID=21700360

Family Applications (1)

Application Number Title Priority Date Filing Date
ES487451A Expired ES8101075A1 (es) 1979-01-10 1980-01-04 Un metodo de preparar nuevas espiro (dibenzo (b,f)oxepinpi- peridinas)

Country Status (10)

Country Link
US (1) US4198418A (es)
EP (1) EP0016261B1 (es)
JP (1) JPS5594387A (es)
AR (1) AR229153A1 (es)
AT (1) ATE2147T1 (es)
AU (1) AU534512B2 (es)
CA (1) CA1142940A (es)
DE (1) DE2964444D1 (es)
ES (1) ES8101075A1 (es)
ZA (1) ZA80115B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0714713D0 (en) * 2007-07-27 2007-09-05 Glaxo Group Ltd Novel compounds
US20100190764A1 (en) * 2007-07-27 2010-07-29 Glaxo Group Limited Novel compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI45449C (fi) * 1965-04-29 1972-06-12 Ciba Geigy Ag Menetelmä uusien faramokologisesti aktiivisten 11-(1-piperatsinyyli)-d ibentso/b,f/tiepin-10(11H)-onien valmistamiseksi
FR1559622A (es) * 1967-08-17 1969-03-14
CH539044A (de) * 1967-10-06 1973-08-31 Gnii Orch Poluproduktov I Kras Verfahren zur Herstellung quaternärer Ammoniumsalze von 1,3-Bis-(aminomethyl)-imidazolidonen
AT306036B (de) * 1971-07-05 1973-03-26 Spofa Vereinigte Pharma Werke Verfahren zur Herstellung von Methylpiperazinderivaten und deren Salzen
GB1447583A (en) * 1974-02-04 1976-08-25 Ici Ltd Xanthene derivatives
GB1434486A (en) * 1974-02-04 1976-05-05 Ici Ltd Thioxanthene derivatives

Also Published As

Publication number Publication date
ES487451A0 (es) 1980-12-01
ZA80115B (en) 1980-12-31
EP0016261B1 (de) 1982-12-29
AR229153A1 (es) 1983-06-30
DE2964444D1 (en) 1983-02-03
AU5449080A (en) 1980-07-17
ATE2147T1 (de) 1983-01-15
EP0016261A1 (de) 1980-10-01
CA1142940A (en) 1983-03-15
AU534512B2 (en) 1984-02-02
JPS5594387A (en) 1980-07-17
US4198418A (en) 1980-04-15

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