ES8101585A1 - Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico - Google Patents

Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico

Info

Publication number
ES8101585A1
ES8101585A1 ES488665A ES488665A ES8101585A1 ES 8101585 A1 ES8101585 A1 ES 8101585A1 ES 488665 A ES488665 A ES 488665A ES 488665 A ES488665 A ES 488665A ES 8101585 A1 ES8101585 A1 ES 8101585A1
Authority
ES
Spain
Prior art keywords
hyperlipoproteinaemia
isobutyrate
para
hypolipaemic
hypocholesterolaemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES488665A
Other languages
English (en)
Other versions
ES488665A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Original Assignee
Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sociedad Espanola de Especialidades Farmaco Terapeuticas SA filed Critical Sociedad Espanola de Especialidades Farmaco Terapeuticas SA
Priority to ES488665A priority Critical patent/ES488665A0/es
Priority to FR8017235A priority patent/FR2476095A1/fr
Priority to BE2/58700A priority patent/BE884722A/fr
Publication of ES8101585A1 publication Critical patent/ES8101585A1/es
Publication of ES488665A0 publication Critical patent/ES488665A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE 2-P-CLOROFENOXIISOBUTIRATO-1,3-DINICOTINATO DE TRIHIDROXIPROPANO. CONSISTE EN HACER REACCIONAR EN REACCION DE ESTERIFICACION, DEL ACIDO P-CLOROFENOXIISOBUTIRICO CON EL 1,3-DIHALOGENO-2-PROPANOL, EN UN MEDIO DISOLVENTE INERTE (TAL COMO BENZOL, TOLUOL O XILOL). EN LA REACCION SE EMPLEAN CATALIZADORES Y MEDIOS DE CAPTACION DEL AGUA PRODUCIDA EN LA REACCION. SE OBTIENE EL COMPUESTO 2,P-CLORO-FENOXIISOBUTIRATO DE 1''.3''-DIHALOGENO-ISOPROPILO, QUE SE HACE REACCIOANR CON LA SAL NICOTINICA DE UN METAL ALCALINO. SE OBTIENE UN COMPUESTO DE FORMULA ESTRUCTURAL (I). *FORMULA* TRATAMIENTO DE HIPERLIPEMIAS E HIPERCOLESTEROLEMIAS PRIMARIA O SECUNDARIA. PREVENCION DE ARTERIOSCLEROSIS.
ES488665A 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico Granted ES488665A0 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES488665A ES488665A0 (es) 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico
FR8017235A FR2476095A1 (en) 1980-02-15 1980-08-01 Glyceryl 2-para-chloro:phenoxy-isobutyrate-1,3-di:nicotinate - hypolipaemic and hypocholesterolaemic used to treat atherosclerosis, hyperlipoproteinaemia and high tri:glyceride plasma levels
BE2/58700A BE884722A (fr) 1980-02-15 1980-08-12 Nouvel ester mixte symetrique de 1,2,3-trihydroxypropane, son procede d'obtention et ses applications therapeutiques

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES488665A ES488665A0 (es) 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico

Publications (2)

Publication Number Publication Date
ES8101585A1 true ES8101585A1 (es) 1980-12-16
ES488665A0 ES488665A0 (es) 1980-12-16

Family

ID=8479833

Family Applications (1)

Application Number Title Priority Date Filing Date
ES488665A Granted ES488665A0 (es) 1980-02-15 1980-02-15 Procedimiento de obtencion de un nuevo compuesto antiateros-clerotico

Country Status (3)

Country Link
BE (1) BE884722A (es)
ES (1) ES488665A0 (es)
FR (1) FR2476095A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692262B1 (fr) * 1992-06-10 1994-08-05 Adir Nouveaux nicotinates de diacylglycerols, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
IL156445A0 (en) 2001-01-26 2004-01-04 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
AR035533A1 (es) 2001-01-26 2004-06-02 Schering Corp Uso de por lo menos un inhibidor de la absorcion de los esteroles o sus sales, solvatos, prodrogas farmaceuticamente aceptables o mezclas de los mismos para la preparacion de un medicamento para el tratamiento de la sitosterolemia, composiciones farmaceuticas, el uso de dichas composiciones para la
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
MXPA04002573A (es) 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
WO2004043457A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
CA2517572C (en) 2003-03-07 2011-12-13 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
JP2006519869A (ja) 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
EP1601668B1 (en) 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
AR065670A1 (es) 2007-03-09 2009-06-24 Indigene Pharmaceuticals Inc Combinacion de metformina r-(+) lipoato y agentes antihiperlipidemicos para el tratamiento de hiperglucemia diabetica y complicaciones diabeticas
TW201628625A (zh) 2015-02-06 2016-08-16 英特賽普醫藥品公司 組合療法醫藥組成物
CN114144185A (zh) 2019-05-30 2022-03-04 英特塞普特医药品公司 用于治疗胆汁淤积性肝病的包含fxr激动剂和贝特类的药物组合物

Also Published As

Publication number Publication date
FR2476095A1 (en) 1981-08-21
ES488665A0 (es) 1980-12-16
FR2476095B1 (es) 1984-03-09
BE884722A (fr) 1980-12-01

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Legal Events

Date Code Title Description
PC1A Transfer granted
FD1A Patent lapsed

Effective date: 19991217