ES8105698A1 - Procedimiento para la obtencion de octapeptidos ciclicos - Google Patents
Procedimiento para la obtencion de octapeptidos ciclicosInfo
- Publication number
- ES8105698A1 ES8105698A1 ES493029A ES493029A ES8105698A1 ES 8105698 A1 ES8105698 A1 ES 8105698A1 ES 493029 A ES493029 A ES 493029A ES 493029 A ES493029 A ES 493029A ES 8105698 A1 ES8105698 A1 ES 8105698A1
- Authority
- ES
- Spain
- Prior art keywords
- trp
- pharmaceutical preparations
- somatostatin
- substituted
- cyclopeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical group NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
- 102000051325 Glucagon Human genes 0.000 abstract 1
- 108060003199 Glucagon Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical group C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
- 102000005157 Somatostatin Human genes 0.000 abstract 1
- 108010056088 Somatostatin Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003178 anti-diabetic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003402 intramolecular cyclocondensation reaction Methods 0.000 abstract 1
- 210000000496 pancreas Anatomy 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 abstract 1
- 229960000553 somatostatin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE OCTAPEPTIDOS CICLICOS DE FORMULA (I), DONDE TRP SIGNIFICA L-TRP Y GABA(AR) SIGNIFICA EL RESTO DE UN ACIDO GAMMA-AMINOBUTIRICO SUSTITUIDO POR UN HIDROCARBILO CICLICO. UN PEPTIDO LINEAL DE FORMULA H-(II'')-C, DONDE (II) REPRESENTA UN RESTO CORRESPONDIENTE AL DEFINIDO EN LA FORMULA (II) Y C SIGNIFICA UN GRUPO HIDROXILO LIBRE, SE CICLIZA, Y EN UN COMPUESTO OBTENIDO DE FORMULA (II), DONDE A SIGNIFICA UN GRUPO PROTECTOR EPSILON-AMINO Y B UN GRUPO PROTECTOR HIDROXILO, EL GRUPO PROTECTOR SE DISOCIA. APLICABLE EN EL TRATAMIENTO DE LAS PERTURBACIONS FUNCIONALES, DONDE LA SECRECION DE LA HORMONA DEL CRECIMIENTO O DE LA GLUCOGENA ES SUPERIOR A LO NORMAL. *FORMULA*
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH624379 | 1979-07-04 | ||
| CH113580 | 1980-02-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8105698A1 true ES8105698A1 (es) | 1981-06-16 |
| ES493029A0 ES493029A0 (es) | 1981-06-16 |
Family
ID=25686753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES493029A Granted ES493029A0 (es) | 1979-07-04 | 1980-07-02 | Procedimiento para la obtencion de octapeptidos ciclicos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4328214A (es) |
| EP (1) | EP0023192B1 (es) |
| KR (1) | KR840000927B1 (es) |
| AU (1) | AU539499B2 (es) |
| CA (1) | CA1148146A (es) |
| DD (1) | DD152543A5 (es) |
| DE (1) | DE3067252D1 (es) |
| DK (1) | DK287680A (es) |
| ES (1) | ES493029A0 (es) |
| FI (1) | FI802079A7 (es) |
| GR (1) | GR69319B (es) |
| HU (1) | HU188081B (es) |
| IE (1) | IE49995B1 (es) |
| IL (1) | IL60474A (es) |
| NO (1) | NO152092C (es) |
| NZ (1) | NZ194227A (es) |
| PT (1) | PT71490A (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4428942A (en) | 1982-05-17 | 1984-01-31 | The Salk Institute For Biological Studies | Analogs of somatostatin |
| GB8318552D0 (en) * | 1983-07-08 | 1983-08-10 | Sandoz Ltd | Organic compounds |
| US4612302A (en) * | 1983-11-14 | 1986-09-16 | Brigham And Women's Hospital | Clinical use of somatostatin analogues |
| US5474980A (en) * | 1984-10-04 | 1995-12-12 | Monsanto Company | Prolonged release of biologically active somatotropins |
| US5086041A (en) * | 1984-10-04 | 1992-02-04 | Monsanto Company | Methods of using prolonged release somatotropin compositions |
| HU196714B (en) * | 1984-10-04 | 1989-01-30 | Monsanto Co | Process for producing non-aqueous composition comprising somatotropin |
| US5411951A (en) * | 1984-10-04 | 1995-05-02 | Monsanto Company | Prolonged release of biologically active somatotropin |
| US4719199A (en) * | 1984-12-14 | 1988-01-12 | Smithkline Beckman Corporation | Diuretic compositions and methods of producing diuresis |
| US4597901A (en) * | 1984-12-14 | 1986-07-01 | Smithkline Beckman Corporation | β-indolylalanyl or β-indolylglycinyl vasopressin antagonists |
| US4684716A (en) * | 1984-12-14 | 1987-08-04 | Smithkline Beckman Corporation | Polypeptide intermediates |
| HUT42101A (en) * | 1985-01-07 | 1987-06-29 | Sandoz Ag | Process for preparing stomatostatine derivatives and pharmaceutical compositions containing such compounds |
| DE3822557C2 (de) * | 1987-07-10 | 1998-07-02 | Ciba Geigy Ag | Arzneimittel, enthaltend Somatostatine |
| FR2663934B1 (fr) * | 1990-06-27 | 1994-06-03 | Adir | Nouveaux derives de l'acide 4 - amino butyrique, leur procede de preparation et les preparations pharmaceutiques qui les contiennent. |
| US5504069A (en) * | 1993-02-11 | 1996-04-02 | Biomeasure, Inc. | Inhibition of trauma-induced tumor growth |
| DE4310643A1 (de) * | 1993-04-01 | 1994-10-06 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| GB9502540D0 (en) * | 1995-02-09 | 1995-03-29 | Zeneca Ltd | Compounds |
| GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| US5597894A (en) * | 1995-06-05 | 1997-01-28 | The Louisiana State University Medical Center Foundation | Multi-tyrosinated somatostatin analogs |
| US6004928A (en) * | 1997-05-13 | 1999-12-21 | Biomeasure, Incorporated | Method of treating hyperlipidemia |
| AU7655098A (en) * | 1997-05-13 | 1998-12-08 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Somatostatin and somatostatin agonists for decreasing body weight |
| WO1998051330A1 (en) * | 1997-05-13 | 1998-11-19 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (S.C.R.A.S.) | Method and compositions for treating hyperlipidemia and other conditions |
| ES2216290T3 (es) * | 1997-05-13 | 2004-10-16 | Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S. | Somatostatina y agonistas de la somatostatina para el tratamiento de insensibilidad a la insulina y de sindrome x. |
| US5968903A (en) * | 1998-05-07 | 1999-10-19 | Biomeasure, Incorporated | Inhibition of H. pylori proliferation |
| AU1602100A (en) | 1998-11-25 | 2000-06-13 | Warner-Lambert Company | Improved gamma amino butyric acid analogs |
| BR0210915A (pt) | 2001-06-08 | 2004-06-08 | Sod Conseils Rech Applic | Análogos quiméricos de somatostatina-dopamina |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| CN101791409A (zh) | 2003-04-22 | 2010-08-04 | 研究及应用科学协会股份有限公司 | 肽载体 |
| AR044852A1 (es) * | 2003-06-24 | 2005-10-05 | Novartis Ag | Una composicion farmaceutica para la administracion parenteral que comprende un analogo de somatostatina |
| CA2727082C (en) | 2008-06-12 | 2019-02-26 | Syntaxin Limited | Fusion proteins for use in suppression of acromegaly |
| CN102083451A (zh) | 2008-06-12 | 2011-06-01 | 赛恩泰新公司 | 癌症的抑制 |
| GB0820970D0 (en) | 2008-11-17 | 2008-12-24 | Syntaxin Ltd | Suppression of cancer |
| JP6869720B2 (ja) | 2013-06-13 | 2021-05-12 | アンチセンス セラピューティクス リミテッド | 併用療法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3875207A (en) * | 1967-01-25 | 1975-04-01 | Ciba Geigy Corp | Process for the temporary protection of amino groups in peptide syntheses |
| US3944590A (en) * | 1967-01-25 | 1976-03-16 | Ciba-Geigy Corporation | Process for the temporary protection of amino groups in peptide syntheses |
| US3725380A (en) * | 1969-04-05 | 1973-04-03 | Hoechst Ag | Method of synthesizing peptides in the presence of a carbodiimide and a 1-hydroxy-benzotriazole |
| CH577464A5 (es) * | 1972-09-22 | 1976-07-15 | Ciba Geigy Ag | |
| LU78191A1 (de) * | 1977-09-28 | 1979-05-25 | Ciba Geigy Ag | Verfahren zur herstellung von neuen cyclopeptiden |
-
1980
- 1980-06-25 US US06/162,712 patent/US4328214A/en not_active Expired - Lifetime
- 1980-06-26 DD DD80222177A patent/DD152543A5/de unknown
- 1980-06-30 EP EP80810216A patent/EP0023192B1/de not_active Expired
- 1980-06-30 IE IE1371/80A patent/IE49995B1/en unknown
- 1980-06-30 DE DE8080810216T patent/DE3067252D1/de not_active Expired
- 1980-06-30 FI FI802079A patent/FI802079A7/fi not_active Application Discontinuation
- 1980-07-02 ES ES493029A patent/ES493029A0/es active Granted
- 1980-07-02 CA CA000355189A patent/CA1148146A/en not_active Expired
- 1980-07-02 IL IL60474A patent/IL60474A/xx unknown
- 1980-07-02 GR GR62343A patent/GR69319B/el unknown
- 1980-07-03 PT PT71490A patent/PT71490A/pt unknown
- 1980-07-03 NZ NZ194227A patent/NZ194227A/xx unknown
- 1980-07-03 NO NO802009A patent/NO152092C/no unknown
- 1980-07-03 AU AU60073/80A patent/AU539499B2/en not_active Ceased
- 1980-07-03 DK DK287680A patent/DK287680A/da not_active Application Discontinuation
- 1980-07-03 HU HU801664A patent/HU188081B/hu unknown
- 1980-07-03 KR KR1019800002634A patent/KR840000927B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IL60474A (en) | 1983-10-31 |
| EP0023192A1 (de) | 1981-01-28 |
| HU188081B (en) | 1986-03-28 |
| GR69319B (es) | 1982-05-14 |
| NO802009L (no) | 1981-01-05 |
| IE49995B1 (en) | 1986-01-22 |
| KR830003401A (ko) | 1983-06-20 |
| NO152092C (no) | 1985-07-31 |
| FI802079A7 (fi) | 1981-01-01 |
| DK287680A (da) | 1981-01-05 |
| KR840000927B1 (ko) | 1984-06-29 |
| ES493029A0 (es) | 1981-06-16 |
| CA1148146A (en) | 1983-06-14 |
| US4328214A (en) | 1982-05-04 |
| PT71490A (de) | 1980-08-01 |
| NZ194227A (en) | 1983-05-31 |
| AU539499B2 (en) | 1984-10-04 |
| EP0023192B1 (de) | 1984-03-28 |
| IL60474A0 (en) | 1980-09-16 |
| IE801371L (en) | 1981-01-04 |
| NO152092B (no) | 1985-04-22 |
| DE3067252D1 (en) | 1984-05-03 |
| DD152543A5 (de) | 1981-12-02 |
| AU6007380A (en) | 1981-01-15 |
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