ES8200361A1 - Procedimiento para la preparacion de derivados de 4-aminome-til-9,10-dihidro-benzo 4,5 ciclohepta 1,2b tiofeno n,n-di- sustituidos - Google Patents
Procedimiento para la preparacion de derivados de 4-aminome-til-9,10-dihidro-benzo 4,5 ciclohepta 1,2b tiofeno n,n-di- sustituidosInfo
- Publication number
- ES8200361A1 ES8200361A1 ES497897A ES497897A ES8200361A1 ES 8200361 A1 ES8200361 A1 ES 8200361A1 ES 497897 A ES497897 A ES 497897A ES 497897 A ES497897 A ES 497897A ES 8200361 A1 ES8200361 A1 ES 8200361A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- tiofeno
- ciclohepta
- benzo
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 2
- 229910052782 aluminium Inorganic materials 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- -1 ARACHYL Chemical class 0.000 abstract 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 159000000011 group IA salts Chemical class 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 229910052744 lithium Inorganic materials 0.000 abstract 1
- 230000003340 mental effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE 4-AMINOMETIL-9,10-DIHIDRO-4H-BENZO(4,5) CICLOHEPTA(1,2B) TIOFENO N,N-DISUSTITUIDOS, DE FORMULA (I), EN QUE R1 Y R2 SON GRUPOS ALQUILO, ARILO, ARALQUILO U OTROS. SE CALIENTA A EBULLICION UN CIANO DERIVADO DE FORMULA (II) EN UN MEDIO HIDROALCOHOLICO ACIDO O ALCALINO. SE TRATA LA MEZCLA CON UN AGENTE HALOGENANTE EN UN DISOLVENTE INERTE, COMO BENCENO. EL CLORURO DE ACIDO OBTENIDO SE HACE REACCIONAR CON AMINAS SECUNDARIAS, EN PRESENCIA DE UNA SAL INORGANICA ALCALINA, EN UN DISOLVENTE APOLAR, Y SE REDUCE EL PRODUCTO EN UNA MEZCLA DE HIDRURO DE LITIO Y ALUMINIO CON TRICLORURO DE ALUMINIO, O CON TETRAHIDROFURANO, A LA TEMPERATURA DE REFLUJO. SE USAN COMO INTERMEDIARIOS EN LA ELABORACION DE PRODUCTOS FARMACEUTICOS PARA EL TRATAMIENTO DE ENFERMEDADES MENTALES.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES497897A ES8200361A1 (es) | 1980-12-18 | 1980-12-18 | Procedimiento para la preparacion de derivados de 4-aminome-til-9,10-dihidro-benzo 4,5 ciclohepta 1,2b tiofeno n,n-di- sustituidos |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES497897A ES8200361A1 (es) | 1980-12-18 | 1980-12-18 | Procedimiento para la preparacion de derivados de 4-aminome-til-9,10-dihidro-benzo 4,5 ciclohepta 1,2b tiofeno n,n-di- sustituidos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES497897A0 ES497897A0 (es) | 1981-11-16 |
| ES8200361A1 true ES8200361A1 (es) | 1981-11-16 |
Family
ID=8481598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497897A Expired ES8200361A1 (es) | 1980-12-18 | 1980-12-18 | Procedimiento para la preparacion de derivados de 4-aminome-til-9,10-dihidro-benzo 4,5 ciclohepta 1,2b tiofeno n,n-di- sustituidos |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8200361A1 (es) |
-
1980
- 1980-12-18 ES ES497897A patent/ES8200361A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES497897A0 (es) | 1981-11-16 |
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