ES8201945A1 - Un procedimiento para preparar 9-aminoalquilfluorenos - Google Patents

Un procedimiento para preparar 9-aminoalquilfluorenos

Info

Publication number
ES8201945A1
ES8201945A1 ES497300A ES497300A ES8201945A1 ES 8201945 A1 ES8201945 A1 ES 8201945A1 ES 497300 A ES497300 A ES 497300A ES 497300 A ES497300 A ES 497300A ES 8201945 A1 ES8201945 A1 ES 8201945A1
Authority
ES
Spain
Prior art keywords
preparing
procedure
formula
aminoalkylfluorenes
aminoalkifluorenes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497300A
Other languages
English (en)
Other versions
ES497300A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES497300A0 publication Critical patent/ES497300A0/es
Publication of ES8201945A1 publication Critical patent/ES8201945A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/10—Impermeable to liquids, e.g. waterproof; Liquid-repellent
    • A41D31/102—Waterproof and breathable
    • A—HUMAN NECESSITIES
    • A41—WEARING APPAREL
    • A41D—OUTERWEAR; PROTECTIVE GARMENTS; ACCESSORIES
    • A41D31/00—Materials specially adapted for outerwear
    • A41D31/04—Materials specially adapted for outerwear characterised by special function or use
    • A41D31/18—Elastic
    • A41D31/185—Elastic using layered materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Textile Engineering (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR 9-AMINOALQUIFLUORENOS DE FORMULA (I). CONSISTE EN HACER REACCIONAR UNA CETONA DE FORMULA (II) CON UN REACTIVO DE GRIGNARD DE FORMULA RR3N (CH2)NMGX Y FINALMENTE TRANSFORMAR EL RESTO R DEL PRODUCTO HIDROGENO. TRATAMIENTO DE ARRITMIAS.
ES497300A 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos Expired ES8201945A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1953379A 1979-03-12 1979-03-12

Publications (2)

Publication Number Publication Date
ES497300A0 ES497300A0 (es) 1982-01-01
ES8201945A1 true ES8201945A1 (es) 1982-01-01

Family

ID=21793707

Family Applications (5)

Application Number Title Priority Date Filing Date
ES489470A Expired ES8104186A1 (es) 1979-03-12 1980-03-12 Un procedimiento para la preparacion de 9-aminoalquilfluore-no
ES497300A Expired ES8201945A1 (es) 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos
ES497301A Expired ES8201946A1 (es) 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos
ES497302A Expired ES8201947A1 (es) 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos
ES497303A Expired ES8201943A1 (es) 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES489470A Expired ES8104186A1 (es) 1979-03-12 1980-03-12 Un procedimiento para la preparacion de 9-aminoalquilfluore-no

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES497301A Expired ES8201946A1 (es) 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos
ES497302A Expired ES8201947A1 (es) 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos
ES497303A Expired ES8201943A1 (es) 1979-03-12 1980-11-28 Un procedimiento para preparar 9-aminoalquilfluorenos

Country Status (40)

Country Link
US (1) US4277495A (es)
EP (1) EP0018076B1 (es)
JP (1) JPS55124743A (es)
KR (2) KR840000279B1 (es)
AR (6) AR228851A1 (es)
AT (4) AT370407B (es)
AU (1) AU527992B2 (es)
BE (1) BE882166A (es)
CA (1) CA1136624A (es)
CH (1) CH643234A5 (es)
CS (4) CS214698B2 (es)
CY (1) CY1345A (es)
DD (1) DD149511A5 (es)
DE (1) DE3064872D1 (es)
DK (1) DK158658C (es)
EG (1) EG14592A (es)
ES (5) ES8104186A1 (es)
FI (3) FI67211C (es)
FR (2) FR2460287A1 (es)
GB (1) GB2046257B (es)
GR (1) GR68035B (es)
GT (1) GT198062477A (es)
HK (1) HK101086A (es)
HU (1) HU179837B (es)
IE (1) IE49553B1 (es)
IL (1) IL59558A (es)
IT (1) IT1140772B (es)
LU (1) LU82236A1 (es)
MA (1) MA18763A1 (es)
MY (1) MY8700080A (es)
NZ (1) NZ193078A (es)
OA (1) OA06486A (es)
PH (1) PH15594A (es)
PL (1) PL122643B1 (es)
PT (1) PT70927A (es)
RO (2) RO79822A (es)
SG (1) SG72286G (es)
SU (2) SU1022656A3 (es)
YU (1) YU65680A (es)
ZA (1) ZA801422B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4212337A (en) * 1978-03-31 1980-07-15 Union Carbide Corporation Closure fastening device
US4452745A (en) * 1981-02-06 1984-06-05 Eli Lilly And Company 9-Aminoalkylfluorenes
US4484352A (en) * 1983-02-07 1984-11-20 Katzin Lawrence F Reclosable plastic bag
US4552982A (en) * 1983-08-01 1985-11-12 Eli Lilly And Company Synthesis of 9-carbamoyl-9-(3-aminopropyl)fluorenes
US4508735A (en) * 1983-09-21 1985-04-02 Eli Lilly And Company Anti-arrhythmic N-alkanoylaminoalkyl fluorenes
US4585894A (en) * 1983-10-19 1986-04-29 Eli Lilly And Company Process for producing 9-carbamoyl fluorene derivatives
IL73261A (en) * 1983-10-19 1988-03-31 Lilly Co Eli Process for producing 9-carbamoyl-9-aminoalkyl fluorene derivatives,and certain intermediates thereof
US4486592A (en) * 1983-10-19 1984-12-04 Eli Lilly And Company 9-Carbamoylfluorene derivatives
DE3444837A1 (de) * 1984-12-08 1986-06-12 Basf Ag, 6700 Ludwigshafen 10,11-dihydro-5h-dibenzo(a,d)cycloheptadien- derivate, ihre herstellung und verwendung
GB9304189D0 (en) * 1993-03-02 1993-04-21 Sturmey Archer Ltd Epicyclic change speed gear hubs
US5739135A (en) * 1993-09-03 1998-04-14 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
US5631203A (en) * 1995-05-04 1997-05-20 Phillips Petroleum Company Metallocene compounds and preparation thereof containing terminal alkynes
JP4129993B2 (ja) * 1996-01-16 2008-08-06 ブリストル―マイヤーズ・スクイブ・カンパニー ミクロソーム・トリグリセリド転移プロテインの立体配座制限芳香族抑制剤および方法
US5760246A (en) * 1996-12-17 1998-06-02 Biller; Scott A. Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB736372A (en) * 1953-05-06 1955-09-07 Miles Lab Fluorene derivatives
GB960758A (en) 1962-12-21 1964-06-17 Boehringer & Soehne Gmbh Basic fluorene derivatives
FR1345419A (fr) * 1962-12-21 1963-12-06 Boehringer & Soehne Gmbh Procédé pour la préparation de dérivés basiques du fluorène et des sels de ces dérivés
DE1203253B (de) * 1963-02-09 1965-10-21 Boehringer & Soehne Gmbh Verfahren zur Herstellung basischer Fluorenderivate und ihrer Salze
FR1482727A (fr) * 1965-06-10 1967-05-26 Upjohn Co 9-(2-amino-1-méthyléthyl) fluoren-9-ols et leur procédé de fabrication
GB1211459A (en) * 1967-05-10 1970-11-04 Abbott Lab Hydroxy amines
US3660485A (en) * 1970-10-05 1972-05-02 Searle & Co Fluorene-9-carboxylic acid hydrazides
US3843657A (en) * 1972-12-08 1974-10-22 Searle & Co 9-dialkylamin oalkyl-n-substituted fluorene-9-carboxamides

Also Published As

Publication number Publication date
US4277495A (en) 1981-07-07
KR840001836B1 (ko) 1984-10-22
ATA114181A (de) 1982-01-15
AR227318A1 (es) 1982-10-15
RO79822A (ro) 1983-02-01
MA18763A1 (fr) 1980-10-01
FI69299B (fi) 1985-09-30
AR225526A1 (es) 1982-03-31
AU527992B2 (en) 1983-03-31
ES497300A0 (es) 1982-01-01
DK158658B (da) 1990-07-02
FI800735A7 (fi) 1980-09-13
IE800494L (en) 1980-09-12
OA06486A (fr) 1981-07-31
CY1345A (en) 1987-01-16
FI67211C (fi) 1985-02-11
DK103380A (da) 1980-09-13
KR840000279B1 (ko) 1984-03-13
FI840921L (fi) 1984-03-07
FI840920A0 (fi) 1984-03-07
ES497303A0 (es) 1982-01-01
IE49553B1 (en) 1985-10-30
FI67211B (fi) 1984-10-31
SU1015820A3 (ru) 1983-04-30
AR230983A1 (es) 1984-08-31
DE3064872D1 (en) 1983-10-27
CS214698B2 (en) 1982-05-28
SG72286G (en) 1987-03-27
AT368125B (de) 1982-09-10
AR228059A1 (es) 1983-01-14
IT1140772B (it) 1986-10-10
ES497302A0 (es) 1982-01-01
FR2457278B1 (es) 1984-06-29
YU65680A (en) 1983-02-28
ZA801422B (en) 1981-10-28
GR68035B (es) 1981-10-27
GB2046257A (en) 1980-11-12
FI69299C (fi) 1986-01-10
GB2046257B (en) 1983-10-19
IT8020502A0 (it) 1980-03-11
ES497301A0 (es) 1982-01-01
DK158658C (da) 1990-12-31
ES489470A0 (es) 1981-04-16
FI70006B (fi) 1986-01-31
FR2460287A1 (fr) 1981-01-23
ES8201943A1 (es) 1982-01-01
CH643234A5 (fr) 1984-05-30
NZ193078A (en) 1981-11-19
AU5630180A (en) 1980-09-18
AR228851A1 (es) 1983-04-29
ES8104186A1 (es) 1981-04-16
CS214696B2 (en) 1982-05-28
MY8700080A (en) 1987-12-31
JPS6314702B2 (es) 1988-04-01
ES8201947A1 (es) 1982-01-01
BE882166A (fr) 1980-09-11
CS214700B2 (en) 1982-05-28
PT70927A (en) 1980-04-01
PH15594A (en) 1983-02-28
AT368131B (de) 1982-09-10
PL122643B1 (en) 1982-08-31
IL59558A0 (en) 1980-06-30
EP0018076B1 (en) 1983-09-21
FR2460287B1 (es) 1983-03-11
FI840920L (fi) 1984-03-07
AT370407B (de) 1983-03-25
ES8201946A1 (es) 1982-01-01
IL59558A (en) 1984-05-31
ATA134480A (de) 1982-08-15
KR830001860A (ko) 1983-05-19
FI70006C (fi) 1986-09-12
LU82236A1 (fr) 1980-06-06
HK101086A (en) 1987-01-02
AR229402A1 (es) 1983-08-15
CS214699B2 (en) 1982-05-28
JPS55124743A (en) 1980-09-26
AT368130B (de) 1982-09-10
DD149511A5 (de) 1981-07-15
SU1022656A3 (ru) 1983-06-07
EP0018076A1 (en) 1980-10-29
HU179837B (en) 1982-12-28
ATA113981A (de) 1982-01-15
GT198062477A (es) 1981-09-02
FR2457278A1 (fr) 1980-12-19
ATA114081A (de) 1982-01-15
EG14592A (en) 1985-03-31
PL222600A1 (es) 1980-12-15
CA1136624A (en) 1982-11-30
FI840921A0 (fi) 1984-03-07
RO85074A (ro) 1984-08-17

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20010201