ES8201977A1 - Procedimiento de preparacion de aminoalcoxipirazoles - Google Patents

Procedimiento de preparacion de aminoalcoxipirazoles

Info

Publication number
ES8201977A1
ES8201977A1 ES500810A ES500810A ES8201977A1 ES 8201977 A1 ES8201977 A1 ES 8201977A1 ES 500810 A ES500810 A ES 500810A ES 500810 A ES500810 A ES 500810A ES 8201977 A1 ES8201977 A1 ES 8201977A1
Authority
ES
Spain
Prior art keywords
alcoxy
pyrazoles
amino
preparation
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500810A
Other languages
English (en)
Other versions
ES500810A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nativelle SA Ets
Original Assignee
Nativelle SA Ets
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nativelle SA Ets filed Critical Nativelle SA Ets
Publication of ES8201977A1 publication Critical patent/ES8201977A1/es
Publication of ES500810A0 publication Critical patent/ES500810A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C07D231/20—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE AMIBOALCOXIPIRAZOLES DE FORMULA (I), EN QUE AR ES FENILO, BENCILO, NAFTILO U OTROS; R1 HIDROGENO O ALQUILO; R2 Y R3, O BIEN SON HIDROGENO O ALQUILO, O BIEN FORMAN UN HETEROCICLO CON EL NITROGENO ADYACENTE. SE HACE REACCIONAR A TEMPERATURA DE 20-100 C UNA AMINOPIRAZOLONA DE FORMULA (II) CON UNA HALOALQUILAMINA DE FORMULA (III), EN QUE X ES HALOGENO, EN PRESENCIA DE UN HIDRURO, UN AMIDURO O UN ALCOHOLATO DE METAL ALCALINO, EN UN SOLVENTE ORGANICO. SE ELIMINA EL DISOLVENTE POR DESTILACION A PRESION REDUCIDA. SE EXTRAE LA FASE ORGANICA CON ACIDO CITRICO Y SE ALCALINIZA CON CARBONATO DE SODIO. SE EXTRAE CON ETER ETILICO Y SE AISLA EL PRODUCTO POR EVAPORACION. DE APLICACION EN EL TRATAMIENTO DE ESTADOS DEPRESIVOS, TRANTORNOS POLIFUNCIONALES Y AFECCIONES CARDIOVASCULARES.
ES500810A 1980-04-01 1981-03-27 Procedimiento de preparacion de aminoalcoxipirazoles Granted ES500810A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8007301A FR2479219A1 (fr) 1980-04-01 1980-04-01 Amino-alcoxy pyrazoles, procede pour leur preparation, et medicaments les contenant

Publications (2)

Publication Number Publication Date
ES8201977A1 true ES8201977A1 (es) 1982-01-01
ES500810A0 ES500810A0 (es) 1982-01-01

Family

ID=9240402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500810A Granted ES500810A0 (es) 1980-04-01 1981-03-27 Procedimiento de preparacion de aminoalcoxipirazoles

Country Status (12)

Country Link
US (1) US4330544A (es)
EP (1) EP0037344B1 (es)
JP (1) JPS56152465A (es)
AT (1) ATE8389T1 (es)
AU (1) AU539177B2 (es)
CA (1) CA1152992A (es)
DE (1) DE3164667D1 (es)
DK (1) DK153547C (es)
ES (1) ES500810A0 (es)
FR (1) FR2479219A1 (es)
GR (1) GR75618B (es)
IE (1) IE51963B1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2513996A1 (fr) * 1981-10-02 1983-04-08 Nativelle Sa Ets Derives du pyrazole, procede pour leur preparation et application en therapeutique
US4550119A (en) * 1983-05-23 1985-10-29 Warner-Lambert Company 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones
DE3532880A1 (de) * 1985-09-14 1987-03-26 Basf Ag 1,4-disubstituierte pyrazolderivate
US4806554A (en) * 1988-01-11 1989-02-21 Hoechst-Roussel Pharmaceuticals, Inc. Pyrazol and indazolpyridinamines
US4962120A (en) * 1989-03-22 1990-10-09 Sterling Drug Inc. 1H-imidazole-1-acetamides
US5547967A (en) * 1993-12-08 1996-08-20 Kali-Chemie Pharma Gmbh (Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them
DE4341749A1 (de) * 1993-12-08 1995-06-14 Kali Chemie Pharma Gmbh 3-(Phenylalkylaminoalkyloxy)-5-phenylpyrazol- Verbindungen sowie Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1385811A (en) * 1972-01-14 1975-03-05 Nativelle Sa Ets 1-amino pyrazole derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2479219A1 (fr) 1981-10-02
JPS56152465A (en) 1981-11-26
DK153547C (da) 1988-12-05
AU539177B2 (en) 1984-09-13
JPH0446953B2 (es) 1992-07-31
DK153547B (da) 1988-07-25
EP0037344B1 (fr) 1984-07-11
DE3164667D1 (en) 1984-08-16
ES500810A0 (es) 1982-01-01
DK144981A (da) 1981-10-02
US4330544A (en) 1982-05-18
GR75618B (es) 1984-08-01
EP0037344A1 (fr) 1981-10-07
IE51963B1 (en) 1987-05-13
FR2479219B1 (es) 1982-04-09
ATE8389T1 (de) 1984-07-15
IE810728L (en) 1981-10-01
CA1152992A (fr) 1983-08-30
AU6892681A (en) 1981-10-08

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